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Cross-presentation
Cross-presentation. Cross-presentation is the ability of certain professional antigen-presenting cells (mostly dendritic cells) to take up, process and present extracellular antigens with MHC class I molecules to CD8 T cells (cytotoxic T cells). Cross-priming, the result of this process, describes the stimulation of naive cytotoxic CD8 + T ...
Cross-Presentation: How to Get there
Cross-presentation has been demonstrated to play an important role in a variety of processes, including the induction of an immune response against viruses that do not infect antigen-presenting cells directly or against tumors of non-hematopoietic origin (Huang et al., 1994; Sigal et al., 1999; den Haan and Bevan, 2001; Heath and Carbone, 2001).
Current Concepts of Antigen Cross-Presentation
The presentation of internalized antigens on MHC I molecules is a process termed cross-presentation. Efficient cross-presentation has been shown to be crucial in, e.g., the induction of an adaptive immune response against tumors and viruses that do not infect DCs directly and in the induction of peripheral tolerance (2-5).
Cross-Presentation
Definition of cross presentation. For the purposes of this review we define cross presentation as presentation of p-MHC-I by cells in which translation of the antigen being presented has not occurred. Examples of such presentation would include professional APC (pAPC)-mediated presentation of virus-encoded antigen when the virus does not infect ...
Cross-presentation: how to get there
The transport of the cross-presentation machinery toward antigen-containing endosomes is induced after stimulation of TLRs. Alternatively, DCs can obtain peptides from neighboring cells via gap junctions. These peptides are thought to subsequently enter the endogenous MHC I-restricted presentation pathway in the ER.
Cross-presentation by dendritic cells
The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross-presentation is mainly ...
Cross Presentation. (cross-presentation, cross-priming) The transfer of antigen from antigen-bearing cell to antigen-presenting cell (dendritic cell). It is called cross presentation because the antigens are not directly transferred to the T cells. The process may involve phagosomes and MHC class I- but also class II-restricted antigens.
The evolving biology of cross-presentation
These have been based on results gathered from many studies using many different forms of antigen, different types of APCs, and different read-outs to define cross-presentation. While the in vivo requirement for the cDC1 lineage has been established for efficient cross-presentation in many settings, much about the molecular mechanism for this ...
Cross-Presentation, Dendritic Cells, Tolerance and Immunity
This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is ...
Cross Presentation
DCs as targets for vaccine design. G.T. Belz, ... D.C. Jackson, in Cytotherapy, 2004 Cross-presentation. Cross-presentation provides a mechanism that allows exogenous Ags to be diverted into the MHC Class I pathway, resulting in their association with Class I molecules and subsequent presentation to CD8 + T cells [32].The process of cross-presentation of self-Ags results in anergy or deletion ...
Cross-presentation in viral immunity and self-tolerance
Cross-presentation is defined as the processing of exogenous antigens into the major histocompatibility complex (MHC) class I pathway. Cross-priming and cross-tolerance refer to the induction of ...
Cross-presentation by dendritic cells
The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8 (+) T cell responses. In vivo, cross-presentation is mainly carried out by specific dendritic cell (DC) subsets through an adaptation of their endocytic and phagocytic pathways. Here, we summarize recent advances ...
A guide to antigen processing and presentation
Abstract. Antigen processing and presentation are the cornerstones of adaptive immunity. B cells cannot generate high-affinity antibodies without T cell help. CD4 + T cells, which provide such ...
Defining cross presentation for a wider audience
Cross presentation is the process of production of peptide-MHC Class I complexes by cells in which the antigen that is the source of peptide is not translated. The majority of recent studies have described many facets of the classical TAP-dependent cross presentation pathway, but numerous pathways for transfer of antigenic material from a donor ...
Current Concepts of Antigen Cross-Presentation
Abstract. Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed cross-presentation and is important role in the generation of an immune response against viruses and tumors, after vaccinations or in the induction of immune tolerance.
The biology and underlying mechanisms of cross-presentation of
Cross-Presentation, Vacuolar Pathway. Exogenous antigen is internalized via phagocytosis, pinocytosis or receptor mediated endocytosis (Step 1). Antigen is cleaved by proteases within the endocytic compartment (primarily by cathepsins) and can be further trimmed by IRAP (Step 2). MHC I molecules are recruited either from the plasma membrane ...
Antigen Processing and Presentation
There is also so called cross-presentation in which exogenous antigens can be presented by MHC class I molecules. Endogenous antigens can also be presented by MHC class II when they are degraded through autophagy. Figure 1. The MHC class I antigen-presentation pathway. MHC class I presentation. MHC class I molecules are expressed by all ...
Frontiers
Delayed Antigen Degradation and its Role in Cross-Presentation. Over the last years, it has become clear that intra-endosomal antigen stability critically regulates cross-presentation, which efficiency is negatively affected by rapid lysosomal degradation of internalized antigens ().Lysosomal maturation and activation of lysosomal proteases is fine-tuned by the transcription factor TFEB, an ...
Lecture 9: What is cross-presentation Flashcards
Term. 1 / 7. What is cross-presentation? Click the card to flip 👆. Definition. 1 / 7. ability for dendritic cells to activate both T helper cells and CTLs by presenting both MHC class I and II (it usually only presents MHC class II) Click the card to flip 👆.
Antigen Cross-Presentation of Immune Complexes
Introduction. The mechanism of cross-presentation allows exogenous antigens to access the processing and presentation machinery of a cell so that exogenous antigenic peptides are displayed on MHC class I molecules for T cell recognition, which consequently leads to the priming of CD8 + T cell responses. As such, the cross-presentation pathway is essential for inducing cytotoxic T-lymphocyte ...
Cross-presentation: underlying mechanisms and role in immune
Cross-presentation was originally discovered as an obscure phenomenon in transplantation immunity. However, it is now clear that it is a major mechanism by which the immune system monitors tissues and phagocytes for the presence of foreign antigen. Cross-presentation is the only pathway by which the immune system can detect and respond to viral ...
Antigen cross-presentation by dendritic cells: A critical axis in
This process, called cross-presentation, is essential for initiating and regulating CD8 + T cell responses against tumors and intracellular pathogens. In this review, we will discuss the role of DCs in cancer immunity, the molecular mechanisms underlying antigen cross-presentation by DCs, the immunosuppressive factors that limit the efficiency ...
What Is Cross-Selling? The Ultimate Guide (2024)
Cross-selling isn't limited to ecommerce stores alone. It also happens in brick-and-mortar stores. Here, a salesperson or the sales team will be able to identify cross-selling opportunities and cross-sell to the customer. Cross-selling examples. Cross-selling efforts are present in all types of businesses.
Understanding the Biology of Antigen Cross-Presentation for the Design
Antigen cross-presentation, the process in which exogenous antigens are presented on MHC class I molecules, is crucial for the generation of effector CD8 + T cell responses. Although multiple cell types are being described to be able to cross-present antigens, in vivo this task is mainly carried out by certain subsets of dendritic cells (DCs). Aspects such as the internalization route, the ...
IMAGES
COMMENTS
Cross-presentation. Cross-presentation is the ability of certain professional antigen-presenting cells (mostly dendritic cells) to take up, process and present extracellular antigens with MHC class I molecules to CD8 T cells (cytotoxic T cells). Cross-priming, the result of this process, describes the stimulation of naive cytotoxic CD8 + T ...
Cross-presentation has been demonstrated to play an important role in a variety of processes, including the induction of an immune response against viruses that do not infect antigen-presenting cells directly or against tumors of non-hematopoietic origin (Huang et al., 1994; Sigal et al., 1999; den Haan and Bevan, 2001; Heath and Carbone, 2001).
The presentation of internalized antigens on MHC I molecules is a process termed cross-presentation. Efficient cross-presentation has been shown to be crucial in, e.g., the induction of an adaptive immune response against tumors and viruses that do not infect DCs directly and in the induction of peripheral tolerance (2-5).
Definition of cross presentation. For the purposes of this review we define cross presentation as presentation of p-MHC-I by cells in which translation of the antigen being presented has not occurred. Examples of such presentation would include professional APC (pAPC)-mediated presentation of virus-encoded antigen when the virus does not infect ...
The transport of the cross-presentation machinery toward antigen-containing endosomes is induced after stimulation of TLRs. Alternatively, DCs can obtain peptides from neighboring cells via gap junctions. These peptides are thought to subsequently enter the endogenous MHC I-restricted presentation pathway in the ER.
The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross-presentation is mainly ...
Cross Presentation. (cross-presentation, cross-priming) The transfer of antigen from antigen-bearing cell to antigen-presenting cell (dendritic cell). It is called cross presentation because the antigens are not directly transferred to the T cells. The process may involve phagosomes and MHC class I- but also class II-restricted antigens.
These have been based on results gathered from many studies using many different forms of antigen, different types of APCs, and different read-outs to define cross-presentation. While the in vivo requirement for the cDC1 lineage has been established for efficient cross-presentation in many settings, much about the molecular mechanism for this ...
This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is ...
DCs as targets for vaccine design. G.T. Belz, ... D.C. Jackson, in Cytotherapy, 2004 Cross-presentation. Cross-presentation provides a mechanism that allows exogenous Ags to be diverted into the MHC Class I pathway, resulting in their association with Class I molecules and subsequent presentation to CD8 + T cells [32].The process of cross-presentation of self-Ags results in anergy or deletion ...
Cross-presentation is defined as the processing of exogenous antigens into the major histocompatibility complex (MHC) class I pathway. Cross-priming and cross-tolerance refer to the induction of ...
The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8 (+) T cell responses. In vivo, cross-presentation is mainly carried out by specific dendritic cell (DC) subsets through an adaptation of their endocytic and phagocytic pathways. Here, we summarize recent advances ...
Abstract. Antigen processing and presentation are the cornerstones of adaptive immunity. B cells cannot generate high-affinity antibodies without T cell help. CD4 + T cells, which provide such ...
Cross presentation is the process of production of peptide-MHC Class I complexes by cells in which the antigen that is the source of peptide is not translated. The majority of recent studies have described many facets of the classical TAP-dependent cross presentation pathway, but numerous pathways for transfer of antigenic material from a donor ...
Abstract. Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed cross-presentation and is important role in the generation of an immune response against viruses and tumors, after vaccinations or in the induction of immune tolerance.
Cross-Presentation, Vacuolar Pathway. Exogenous antigen is internalized via phagocytosis, pinocytosis or receptor mediated endocytosis (Step 1). Antigen is cleaved by proteases within the endocytic compartment (primarily by cathepsins) and can be further trimmed by IRAP (Step 2). MHC I molecules are recruited either from the plasma membrane ...
There is also so called cross-presentation in which exogenous antigens can be presented by MHC class I molecules. Endogenous antigens can also be presented by MHC class II when they are degraded through autophagy. Figure 1. The MHC class I antigen-presentation pathway. MHC class I presentation. MHC class I molecules are expressed by all ...
Delayed Antigen Degradation and its Role in Cross-Presentation. Over the last years, it has become clear that intra-endosomal antigen stability critically regulates cross-presentation, which efficiency is negatively affected by rapid lysosomal degradation of internalized antigens ().Lysosomal maturation and activation of lysosomal proteases is fine-tuned by the transcription factor TFEB, an ...
Term. 1 / 7. What is cross-presentation? Click the card to flip 👆. Definition. 1 / 7. ability for dendritic cells to activate both T helper cells and CTLs by presenting both MHC class I and II (it usually only presents MHC class II) Click the card to flip 👆.
Introduction. The mechanism of cross-presentation allows exogenous antigens to access the processing and presentation machinery of a cell so that exogenous antigenic peptides are displayed on MHC class I molecules for T cell recognition, which consequently leads to the priming of CD8 + T cell responses. As such, the cross-presentation pathway is essential for inducing cytotoxic T-lymphocyte ...
Cross-presentation was originally discovered as an obscure phenomenon in transplantation immunity. However, it is now clear that it is a major mechanism by which the immune system monitors tissues and phagocytes for the presence of foreign antigen. Cross-presentation is the only pathway by which the immune system can detect and respond to viral ...
This process, called cross-presentation, is essential for initiating and regulating CD8 + T cell responses against tumors and intracellular pathogens. In this review, we will discuss the role of DCs in cancer immunity, the molecular mechanisms underlying antigen cross-presentation by DCs, the immunosuppressive factors that limit the efficiency ...
Cross-selling isn't limited to ecommerce stores alone. It also happens in brick-and-mortar stores. Here, a salesperson or the sales team will be able to identify cross-selling opportunities and cross-sell to the customer. Cross-selling examples. Cross-selling efforts are present in all types of businesses.
Antigen cross-presentation, the process in which exogenous antigens are presented on MHC class I molecules, is crucial for the generation of effector CD8 + T cell responses. Although multiple cell types are being described to be able to cross-present antigens, in vivo this task is mainly carried out by certain subsets of dendritic cells (DCs). Aspects such as the internalization route, the ...