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QIMR Berghofer Medical Research Institute (QIMR)

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The Queensland Institute of Medical Research was established in 1945 to research tropical and infectious diseases found in northern Australia. Today, QIMR Berghofer is one of Australia’s largest medical research institutes, renowned for its world-leading efforts in both discovery research and translational research. The Institute’s research is focused on cancer, infectious diseases, mental health, and chronic disorders. The Institute includes 55 laboratories across four separate departments: Cell and molecular biology, genetics and computational biology, immunology, and population health. Working in close collaboration with clinicians, hospitals, universities and research institutes in Australian and around the world, the Institute’s aim is to improve human health by developing new and better prevention strategies, diagnostics and treatments.

• Queensland statutory authority

Strengths and capabilities

• Cancer research
• Mental health
• Infectious diseases
• Chronic disorders
• Clinical trials
• Cellular therapeutics

Facilities and major equipment

• Good Manufacturing Practice (GMP) facility for cellular therapeutics
• Two quarantine-approved PC2 and PC3 insectaries
• ACRF Centre for Comprehensive Biomedical Imaging
• Physical Containment Class 2 (PC2) laboratories
• Physical Containment Class 3 (PC3) laboratories
• Clinical trials facility

Achievements of the centre

• Discovery of Ross River virus, surveillance techniques for monitoring mosquitoes, and clinical trials for malaria vaccines
• Clinical trials for immunotherapy treatments of brain cancer; skin cancer prevention, detection
• Developing a diagnostic test for depression

Key science sectors

More information about the sectors this centre is involved in:

• Biotechnology
• Engineering
• Environment and nature
• Health and medical

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Queensland Institute of Medical Research

Established in 1945 by the Queensland Government, the Queensland Institute of Medical Research (QIMR) is one of the largest and most successful medical research institutes in Australia, and is recognised worldwide for the quality of its research.

Originally established to further the study of tropical diseases in North Queensland, QIMR has broadened the scope of research to include the genetic and environmental influences of a range of diseases including cancer, asthma, HIV, malaria, endometriosis and dengue fever.

QIMR is home to more than 700 scientists, students and support staff in six research departments (in 50 separate laboratories) and a corporate division. Because of its close proximity to major teaching hospitals and The University of Queensland Medical School, the Institute is ideally placed for clinical research collaborations and as a centre for research seminars and symposia.

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Displaying all articles

Mutant malaria parasites resistant to antimalarial Atovaquone cannot spread: new research

Prodita Sabarini , The Conversation

Nobel Prize in Chemistry highlights how our bodies can repair our fragile DNA

Kum Kum Khanna , Queensland Institute of Medical Research ; Amanda L Bain , QIMR Berghofer Medical Research Institute , and Janelle L Harris , QIMR Berghofer Medical Research Institute

Genetics of allergies is nothing to sneeze at

Manuel Ferreira , Queensland Institute of Medical Research

New therapy holds promise for aggressive breast cancers

Fron Jackson-Webb , The Conversation

Research reveals how the body fights malaria

Sunanda Creagh , The Conversation

Understanding the genetic basis of melanoma

Stuart MacGregor , Queensland Institute of Medical Research

Group Leader, Immunology and Infection Laboratory, Queensland Institute of Medical Research

Senior research scientist, Queensland Institute of Medical Research

Professor in Infectious Diseases, Queensland Institute of Medical Research

Group Leader, Signal Transduction Laboratory, Queensland Institute of Medical Research

Geneticist and Team Head, Asthma Genetics Lab, Queensland Institute of Medical Research

Senior Research Fellow, Queensland Institute of Medical Research

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Queensland Institute of Medical Research

By JOL Admin | 14 November 2015

1945 saw the establishment of the Queensland Institute of Medical Research (QIMR). Since that time, the QIMR has become a world leading medical research institute, focusing on cancer, infectious diseases and mental health.

The genesis of the QIMR was in October 1944, when Dr Edward Derrick, Director of the Laboratory of Microbiology and Pathology was asked to investigate the extension of medical research in Queensland by the State Government.

Derrick recommended that a Medical Research Advisory Committee be formed to oversee the establishment of an Institute of Medical Research. This committee was formed in April 1945 with Derrick as Chairman. The committee's recommendations formed the basis of the Bill tabled in the Queensland Parliament on September 6, 1945. The Queensland Institute of Medical Research Act of 1945 was gazetted on 19 January 1945. Initially the purpose of the QIMR was to research diseases such as Q fever, scrub typhus and leptospirosis.

https://www.youtube.com/watch?v=H08Qo7U9VR8

A council was formed to manage and control the Institute. The first meeting of the council was held on February 8 1946. The first Chairman was Sir Raphael Cilento M.D., who was Director-General of Health and Medical Services in Queensland, 1934-45 and Professor of Social and Tropical Medicine at the University of Queensland. Also on the council was Dr Abraham Fryberg, State Health Officer and deputy-chairman on the council, and Dr Aubrey Pye, General Medical Superintendent at the Royal Brisbane Hospital, 1932-67.

Dr Edward Holbrook Derrick, 1940.

Sir Raphael Cilento, June 1945. John Oxley Library, State Library of Queensland. Neg 188180

Dr Aubrey Pye. John Oxley Library, State Library of Queensland. Neg 108297

The Institute was allowed to set up premises in a disused army building in Victoria Park. The building was 252 feet (77 metres) by 47 feet (14 metres), with 11,844 square feet (1,100 square metres) of floor space. According to the 1946 annual report for QIMR, practically all their equipment was obtained from the recently disbanded Land Headquarters Medical Research Unit in Cairns, and included centrifuges, dissecting microscopes, a vacuum pressure pump and a hot-air oven. The annual report also states that the Institute library collection had begun growing with the purchase of £148 of books and the Health Department donating back issues of various scientific journals.

Doctor I. M. Mackerras. First director of the Queensland Institute of Medical Research. John Oxley Library, State Library of Queensland. Neg 195470

QIMR was inducted into the Queensland Business Leaders Hall of Fame in 2010.

You can browse our collection of publications and images related to the Queensland Institute of Medical Research via our One Search catalogue .

State Library of Queensland also hold  30400 Q Fever Research Papers 1930-1960 - papers and correspondence relating to Q Fever studies by Dr Edward Holbrook Derrick, 1898-1976, including first 300 cases of the disease, laboratory notes, original photographs and correspondence from France and French Africa regarding the disease.

Myles Sinnamon - Project Coordinator, State Library of Queensland

Previously titled -  70th anniversary - Queensland Institute of Medical Research

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The Queensland Cabinet and Ministerial Directory

World-class medical research institute gets multimillion dollar expansion.

Published Tuesday, 08 June, 2021 at 09:09 AM

JOINT STATEMENT

Premier and Minister for Trade The Honourable Annastacia Palaszczuk

Deputy Premier and Minister for State Development, Infrastructure, Local Government and Planning The Honourable Dr Steven Miles

Treasurer and Minister for Investment The Honourable Cameron Dick

A world leading Queensland medical research facility will receive a multimillion-dollar investment to ramp up the development and manufacturing of vaccines.

The project is the first to be announced under the Palaszczuk Government’s new flagship $1.84 billion Queensland Jobs Fund.

Premier Annastacia Palaszczuk said her government was investing $20 million towards the development of a new Translational Manufacturing Institute at the existing Translational Research Institute (TRI).

“The $1.84 billion Queensland Jobs Fund is the next evolution of Queensland’s approach to industry development and jobs creation,” the Premier said.

“People and businesses are moving to Queensland in droves because they know it is one of the safest places in the world to live, work and raise a family.

“My government will provide up to $20 million to expand the existing TRI to include a new state-of-the-art Translational Manufacturing Institute called “TMI@TRI”.

“This will accelerate development of one of the State’s most important health-research precincts and ramp up Australia’s capacity to develop our biomedical industry and manufacture vaccines.

“It will also support an estimated 500 jobs over 10 years.”  

The project is the first to be announced as part of the Government’s new $350 million Industry Partnership Program, within the $1.84 billion Queensland Jobs Fund unveiled today.

Deputy Premier Steven Miles said Queensland could be a vaccine manufacturing location for the whole country.

“The Queensland Jobs Fund is the government’s next step toward Queensland’s economic recovery,” Mr Miles said.

“What better project to kick it off than an investment in biomedical manufacturing that will create high-skilled jobs in Queensland and could lead to the development of life saving vaccines.  

“I want Queensland to lead the country in vaccine research, development, and manufacturing, and I’ve been talking to leading biomedical experts about how to do this.

“TMI@TRI was one of their strong recommendations.

“We want to keep growing the state’s biomedical sector, which already employs more than 10,000 people across more than 1200 companies.

“From the very start of the pandemic, Queenslanders have shown the world the capability of our biomedical research and development.

“Scaling up manufacturing is the next frontier for us. Imagine Queensland becoming Australia’s leading vaccine manufacturing location, right here at Woolloongabba.”

Treasurer and Minister for Investment, Cameron Dick said that under the $1.84 billion fund, the government is working to supercharge the economic recovery.

“Our strong health response to COVID-19 has enabled us to accelerate the recovery of our economy, which is now larger than what it was pre-pandemic,” the Treasurer said.

“We’re now ready to drive that next phase of economic growth”.

“Queensland’s COVID19 economic recovery plan is unashamedly focused on growing Queensland jobs and our state’s manufacturing base

“The Queensland Jobs Fund will help us unlock private sector investment to achieve this.

“If there is one thing that the pandemic has taught us, it is that we need to manufacture more things in Queensland, by Queenslanders, for Queenslanders.

“This includes manufacturing more medical equipment, personal protective equipment, and vaccines right here in our backyard.

“We want to work with investors on high impact projects will create a new generation of jobs now and well into the future.”

CEO of the Translational Research Institute Scott Bell said that the establishment of the Translational Manufacturing Institute (TMI@TRI) will support the local retention of start-ups to advance the commercialisation of their products, and help this industry realise economic and export opportunities.

“The provision of fully operational Good Manufacturing Practice cleanrooms will also see up to 100 people gain hands-on training in cleanroom processes and advanced manufacturing annually, creating a highly skilled workforce for the medtech industry.”

Professor Ian Frazer AC FRS, co-inventor of the Gardasil vaccine for cervical cancer said because of Australia’s limited manufacturing capability for biological products in the 1970s, the cervical cancer vaccine was unable to be tested and manufactured locally.

“This meant that large-scale clinical trials were conducted overseas. This remains the case today,” he said.

“I’ve recently contributed to the development of two research products, a potential treatment for COVID-19 and an immunotherapy for head and neck cancer.

“These were manufactured overseas, because we lacked the capacity to produce them here. 

“I would like to see Queensland help Australia to develop the capacity and capability to manufacture products like these here and TMI@TRI can help us achieve this.”

TRI has sought Australian Government funding under the Modern Manufacturing Initiative (MMI) for this expansion at the Princess Alexandra Hospital Precinct.

The Queensland Government is prepared to support the project with up to $20 million, within the boundaries of the MMI funding guidelines, and is encouraging the Australian Government to support TMI@TRI.

The TMI@TRI project aligns with the government’s  Queensland Biomedical 10-Year Roadmap and Action Plan  to make Queensland a globally competitive Asia-Pacific biomedical hub by 2027.

Find out more at www.qld.gov.au/qldjobsfund

Media contact:        Deputy Premier’s Office - Katharine Wright 0428 957 903 Treasurer’s Office - Geoff Breusch 0417 272 875

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UQ study unlocks potential for advanced bladder cancer immunotherapy

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University of Queensland research could lead to a more effective immunotherapy treatment against bladder cancer.

A team led by Associate Professor Fernando Guimaraes from UQ’s Frazer Institute has found the mechanism used by bladder cancer to suppress the immune system’s natural killer (NK) cells.

“We found that cancer suppresses immune cells by releasing a protein called TGF-β – and blocking that protein may offer a new therapy for some of the worst types of the cancer,” Dr Guimaraes said.

“NK cells are components of the immune system that naturally attack cancer cells and are a focus of emerging cancer treatments, including antibody-based immunotherapies.

“Our research is also a step towards clinical trials to explore the effectiveness of TGF-β inhibitors combined with NK cell-based therapies.

“Our work is all about unlocking the power of immunotherapy and our hope is that this leads to new bladder cancer therapies within 3 to 5 years.”

Bladder cancer is the ninth most common malignancy in the world – in 2023 more than 3000 people were diagnosed in Australia, with more than 1000 deaths.  

The bladder cancer immune suppression mechanism was discovered by Dr Guimaraes’ PhD candidate Joshua Wong while working at Queensland’s Translational Research Institute (TRI).

It really was a eureka moment and it’s extremely motivating to come in here every day and do your best work, because ultimately we are trying to find a cure for cancer.”  Joshua Wong, PhD candidate

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The standard treatment for early-stage bladder cancer remains endoscopic surgery, occasionally combined with chemotherapy or immunotherapy.

For advanced forms of the disease, more invasive surgery or radiotherapy is combined with chemotherapy or immunotherapy, which is associated with significant ill health and life-long impacts on quality of life.

The UQ team collaborated with Princess Alexandra Hospital urologists including Dr Handoo Rhee, Professor Eric Chung and Dr Alice Nicol.

The research was published in The Lancet’s  eBioMedicine .

Posted in: Medical Research News | Medical Condition News

Tags: Antibody , Bladder , Bladder Cancer , Cancer , Cancer Immunotherapy , Cell , Chemotherapy , Hospital , Immune System , Immunotherapy , Protein , Radiotherapy , Research , Surgery

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Dr | Senior Research Officer

Molecular Parasitology

[email protected]

CAREER HISTORY

Dr Hong You is a molecular parasitologist and senior research officer (SRO-6) at QIMR Berghofer in the molecular parasitology laboratory. She is also an adjunct senior lecturer at the School of Veterinary Science, University of Queensland (UQ). After completing her PhD study at UQ in 2010, her research has been focused on the identification / characterisation of vaccine or drug targets against schistosome infections by exploiting new, cutting-edge technologies for gene functional studies including CRISPR-based systems (CRISPR/Cas9 and CRISPR interference/activation), transcriptomics, proteomics, and RNA interference. Her research also extended the development of next-generation point-of-care diagnostics tools (by using CRISPR-Cas12/13 system) for schistosomiasis and other helminthic diseases. Dr You has accumulated rich experience in schistosome developmental biology, immunology associated with parasite-host interactions and functional genomic studies of schistosomes. She has acquired skills in performing immunological assessments of vaccine efficacy in animal vaccine/challenge trials both in the laboratory and in the field.

CURRENT APPOINTMENTS

2014-current : Senior Research Officer at QIMR Berghofer;

2016-current : Adjunct Senior Lecturer at the School of Veterinary Science, University of Queensland

PREVIOUS APPOINTMENTS

2013-2017 : NHMRC Early Career Fellowship

2010-2013 : Research Officer, QIMR Berghofer

2006-2007 : Associate Professor, Xinjiang Veterinary Research Institute, China

1994-2006 : Assistant Research Fellow, Xinjiang Veterinary Research Institute, China

ORCID NUMBER

0000-0002-8790-7793

CURRENT AREA OF RESEARCH

Hong’s research has been focused on biology/molecular parasitology (Schistosomes, Echinococcus) in the areas of identification and characterization of novel/unknown genes as vaccine / drug targets, immunological assessment of vaccine/drug efficacy in animal models and natural hosts in the field. However, a major challenge in the schistosomiasis research community is the lack of suitable tools to effectively characterise schistosome gene products as potential new drug/vaccine targets. By introducing the CRISPR-mediated technology, a powerful gene editing tool, into schistosomes, Dr You recently developed a CRISPR/Cas9-based editing system for genomic functional study. For the first time, she has successfully established CRISPR interference/activation approaches in schistosome providing effective tools for improved gene functional study by selectively perturbing/enhancing gene expression, with the potential of the approach to be extended to the study of other parasitic helminths and used as a powerful drug screen system. By further exploring CRISPR-Cas12/13 diagnostic platforms, Dr You has also developed for the first time, new generation point-of-care diagnostics tools for schistosomiasis, which are sensitive, cost-effective, field-friendly diagnostics approaches for future wide-scale application to other parasitic neglected tropical diseases globally.

RESEARCH HIGHLIGHTS

• First author of the most comprehensive report, accepted (in-press) by Clinical Microbiology Reviews, of mRNA vaccine technology era and the future control of parasitic infections.
• Lead author of the most advanced reports by utilizing the edge-cutting CRISPR based technologies in schistosomes.
• Top 1% of scholars writing about Schistosoma (ranking as 16) over the past 10 years (2001-2021), by Expertscape’s PubMed-based lgorithms https://expertscape.com/ex/schistosoma

PROFESSIONAL MEMBERSHIPS

2005-present : Australian Society for Parasitology.

2018 -present : QIMR Berghofer Postdoctoral Committee, member.

AWARDS RECOGNITION

• 2022: Award in recognition of outstanding contributions to the Molecular Parasitology Group and QIMR Berghofer Medical Research Institute.
• 2022: Australian Society for Parasitology Network for Parasitology Researcher Exchange Travel Award for visiting University of Würzburg, Institute of Hygiene and Microbiology, Germany for 1 week.
• 2019: Australian Society for Parasitology Network for Parasitology Researcher Exchange Travel Award for visiting Baylor University, Texas, USA for 4 weeks.
• 2017: Australian Society for Parasitology Network for Parasitology Researcher Exchange Travel Award for visiting George Washington University, USA for 6 weeks.
• 2017: Australian Infectious Diseases Research Centre Travel Award.
• 2013: Cold Spring Harbor Asia fellowship.
• 2013: Chinese Academic visiting scholarship supported by State Administration of Foreign Experts Affairs of China.
• 2013: Travel Bursary Funding supported by Queensland Emory Development Alliance for visiting Emory University US for 3 months.
• 2012: Australian Society for Parasitology Network for Parasitology Researcher Exchange Travel Award for visiting Emory University US for 3 months.
• 2011: Josephine Mackerras Training Fellowship Supported by Australian Centre for Vaccine Development for visiting Emory University in Atlanta, USA.

EDUCATIONAL BACKGROUND

• 2005-2010: Doctor of Philosophy, University of Queensland, Australia
• 1999-2002: Master of Veterinary Science (Doctor of Veterinary Medicine, DVM), Xinjiang Agricultural University, China.
• 1990-1994: Bachelor of Veterinary Science, Shehezi University, Shihezi, China.