An official website of the United States government
The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
- Publications
- Account settings
Trending Articles
- Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice. Fu K, et al. Cell. 2024. PMID: 39461336 No abstract available.
- Tobacco Smoke Plays an Important Role in Initiation and Development of Lung Cancer by Promoting the Characteristics of Cancer Stem Cells. Lu L, et al. Cancer Manag Res. 2020. PMID: 33116833 Free PMC article. Review.
- Amino acid is a major carbon source for hepatic lipogenesis. Liao Y, et al. Cell Metab. 2024. PMID: 39461344
- Global, regional, and national burden of injuries, and burden attributable to injuries risk factors, 1990 to 2019: results from the Global Burden of Disease study 2019. GBD 2019 Injuries Collaborators. Public Health. 2024. PMID: 39454232
- CAR-Macrophage Therapy Alleviates Myocardial Ischemia-Reperfusion Injury. Wang J, et al. Circ Res. 2024. PMID: 39465245
Latest Literature
- Ann Oncol (1)
- Gastroenterology (2)
- J Am Acad Dermatol (5)
- J Am Coll Cardiol (3)
- J Biol Chem (9)
- J Neurosci (2)
- Spine (Phila Pa 1976) (5)
NCBI Literature Resources
MeSH PMC Bookshelf Disclaimer
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
IMAGES
VIDEO
COMMENTS
Tolerance to the effects of alcohol is an important element in major diagnostic classifications of alcohol use disorders (AUD) [1, 2]. Broadly, tolerance refers to the need to consume larger amounts of alcohol to obtain the same effect, or a decrease in effect at the same dose.
Highlights. •. Tolerance is a diagnostic criterion for alcohol use disorder. •. Alcohol tolerance has been neglected in preclinical research. •. Understanding alcohol tolerance may …
People likely acquire tolerance to alcohol’s behavioral effects in drinking situations where reliable cues, such as liquor bottles, signal alcohol availability. Research indicates that when alcohol …
In this mini-review, we provide a theoretical framework for alcohol tolerance. We then briefly describe chronic tolerance, followed by a longer discussion of behavioral and neurobiological …
In this review, we provide a conceptual framework for the neurobiology of alcohol tolerance. We then discuss functional tolerance, in which we briefly describe chronic tolerance …
Alcohol tolerance, defined as (1) the need for noticeably increased amounts of alcohol in order to achieve the desired effect or (2) diminished effect with continued use of the same amount, is a …