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Articles in 2024
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.
- Caroline L. Holley
- Mercedes Monteleone
- Kate Schroder
Publisher Correction: Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE
- Caterina E. Faliti
- Trinh T. P. Van
- Ignacio Sanz
Author Correction: Cutaneous T cell lymphoma atlas reveals malignant T H 2 cells supported by a B cell-rich tumor microenvironment
- Johanna Strobl
- Muzlifah Haniffa
Circulating tumor-reactive KIR + CD8 + T cells suppress anti-tumor immunity in patients with melanoma
Tumor-antigen-specific CD8 + T cells are generally thought to help fight against cancer, but here the authors identify a subpopulation of CD8 + T cells that are associated with a poor clinical outcome in melanoma. Although these cells can recognize tumor antigens, they suppress cancer immunity.
- Benjamin Y. Lu
- Liliana E. Lucca
- David A. Hafler
Pregnancy stress
- Ioana Staicu
IL-4 promotes immunotherapy resistance
- Paula Jauregui
T H 1 responses in type 2 diabetes
- Stephanie Houston
The brain tames autoimmunity
- Nicholas J. Bernard
3D imaging of the synovium defines an immune defense system at the blood–joint barrier
Circulating immune stimuli access the joint through fenestrated capillaries that are located at the outer edge of the synovium. This area of vulnerability is policed by interacting macrophages and nociceptor neurons that work together as a functional unit.
Next-generation combination approaches for immune checkpoint therapy
In this Review, Sharma and colleagues describe the current landscape of combination therapies and discuss requirements for the development of effective combination strategies.
- Sangeeta Goswami
- Kristen E. Pauken
- Padmanee Sharma
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge
Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vascular, neuronal and immune components.
- Tetsuo Hasegawa
- Colin Y. C. Lee
- Menna R. Clatworthy
A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer
Here, the authors show that signal transducer and activator of transcription 3 (STAT3) has dual functions in small cell lung cancer as its deletion inhibited primary tumor growth but boosted metastatic spread. These seemingly opposing functions are a result of the requirement of STAT3 for stimulator of interferon genes–interferon signaling in metastasis and the authors show how it can be targeted in mice.
- Aleks C. Guanizo
- Quinton Luong
- Daniel J. Gough
PD-1 and CD73 on naive CD4 + T cells synergistically limit responses to self
Ley and colleagues show that negative selection only partially explains the difference between CD4 + T cell responses to self and foreign peptides and that PD-1 and CD73 synergistically limit the CD4 + T cell responses to self.
- Felix Sebastian Nettersheim
- Simon Brunel
The diverse roles of neutrophils from protection to pathogenesis
In this Review, Herro and Grimes summarize the most recent key findings surrounding protective versus pathogenic functions of neutrophils, elaborating on phenotype-specific subsets of neutrophils and their involvement in homeostasis and disease.
- H. Leighton Grimes
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling
Wang and colleagues show that in skeletal muscle cells and cardiomyocytes, the glucose transporter GLUT4 is a negative regulator of RIG-I-like receptor signaling during viral infection by redistributing RIG-I and MDA5 to the plasma membrane and attenuating interferon responses.
- Andrew G. Harrison
- Duomeng Yang
- Penghua Wang
Remodeling of Il4-Il13-Il5 locus underlies selective gene expression
O’Shea and colleagues examine the three-dimensional chromatin architecture of the type 2 cytokine locus and how it differs between innate ILC2 cells and adaptive T H 2 lymphocytes.
- Hiroyuki Nagashima
- Justin Shayne
- John J. O’Shea
Author Correction: NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
- Vedrana Jelenčić
- Marko Šestan
- Bojan Polić
B cells infiltrate cutaneous T cell lymphomas
Cutaneous T cell lymphoma is a rare, difficult to diagnose malignancy of T cells. Malignant T cells, together with populations of stromal cells and B cells, shape their own tumor niche for improved cancer cell survival in the skin.
Cutaneous T cell lymphoma atlas reveals malignant T H 2 cells supported by a B cell-rich tumor microenvironment
Haniffa and colleagues provide diagnostic aids, potential biomarkers for disease staging and therapeutic strategies for cutaneous T cell lymphoma.
Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE
SLE is a heterogeneous disorder that is characterized by different immune endotypes. Faliti et al. follow the immune memory responses upon mRNA COVID-19 vaccinations in a large cohort of patients with SLE. They note that skewed immune responses, such as lower seroconversion and neutralization, might be due to extrafollicular B and T cell biases in SLE endotypes.
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