experiments done on humans

10 Outrageous Experiments Conducted on Humans

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Prisoners, the disabled, the physically and mentally sick, the poor -- these are all groups once considered fair game to use as subjects in your research experiments. And if you didn't want to get permission, you didn't have to, and many doctors and researchers conducted their experiments on people who were unwilling to participate or who were unknowingly participating.

Forty years ago the U.S. Congress changed the rules; informed consent is now required for any government-funded medical study involving human subjects. But before 1974 the ethics involved in using humans in research experiments was a little, let's say, loose. And the exploitation and abuse of human subjects was often alarming. We begin our list with one of the most famous instances of exploitation, a study that eventually helped change the public view about the lack of consent in the name of scientific advancements.

Tuskegee Syphilis Study
The Nazi Medical Experiments
Watson's 'Little Albert' Experiment
The Monster Study of 1939
Stateville Penitentiary Malaria Study
The Aversion Project in South Africa
Milgram Shock Experiments
CIA Mind-Control Experiments (Project MK-Ultra)
The Human Vivisections of Herophilus

10: Tuskegee Syphilis Study

Syphilis was a major public health problem in the 1920s, and in 1928 the Julius Rosenwald Fund, a charity organization, launched a public healthcare project for blacks in the American rural south. Sounds good, right? It was, until the Great Depression rocked the U.S. in 1929 and the project lost its funding. Changes were made to the program; instead of treating health problems in underserved areas, in 1932 poor black men living in Macon County, Alabama, were instead enrolled in a program to treat what they were told was their "bad blood" (a term that, at the time, was used in reference to everything from anemia to fatigue to syphilis). They were given free medical care, as well as food and other amenities such as burial insurance, for participating in the study. But they didn't know it was all a sham. The men in the study weren't told that they were recruited for the program because they were actually suffering from the sexually transmitted disease syphilis, nor were they told they were taking part in a government experiment studying untreated syphilis, the "Tuskegee Study of Untreated Syphilis in the Negro Male." That's right: untreated.

Despite thinking they were receiving medical care, subjects were never actually properly treated for the disease. This went on even after penicillin hit the scene and became the go-to treatment for the infection in 1945, and after Rapid Treatment Centers were established in 1947. Despite concerns raised about the ethics of the Tuskegee Syphilis Study as early as 1936, the study didn't actually end until 1972 after the media reported on the multi-decade experiment and there was subsequent public outrage.

9: The Nazi Medical Experiments

During WWII, the Nazis performed medical experiments on adults and children imprisoned in the Dachau, Auschwitz, Buchenwald and Sachsenhausen concentration camps. The accounts of abuse, mutilation, starvation, and torture reads like a grisly compilation of all nine circles of hell. Prisoners in these death camps were subjected to heinous crimes under the guise of military advancement, medical and pharmaceutical advancement, and racial and population advancement.

Jews were subjected to experiments intended to benefit the military, including hypothermia studies where prisoners were immersed in ice water in an effort to ascertain how long a downed pilot could survive in similar conditions. Some victims were only allowed sea water, a study of how long pilots could survive at sea; these subjects, not surprisingly, died of dehydration. Victims were also exposed to high altitude in decompression chambers -- often followed with brain dissection on the living -- to study high-altitude sickness and how pilots would be affected by atmospheric pressure changes.

Effectively treating war injuries was also a concern for the Nazis, and pharmaceutical testing went on in these camps. Sulfanilamide was tested as a new treatment for war wounds. Victims were inflicted with wounds that were then intentionally infected. Infections and poisonings were also studied on human subjects. Tuberculosis (TB) was injected into prisoners in an effort to better understand how to immunize against the infection. Experiments with poison, to determine how fast subjects would die, were also on the agenda.

The Nazis also performed genetic and racially-motivated sterilizations, artificial inseminations, and also conducted experiments on twins and people of short stature.

8: Watson's 'Little Albert' Experiment

In 1920 John Watson, along with graduate student Rosalie Rayner, conducted an emotional-conditioning experiment on a nine-month-old baby -- whom they nicknamed "Albert B" -- at Johns Hopkins University in an effort to prove their theory that we're all born as blank slates that can be shaped. The child's mother, a wet nurse who worked at the hospital, was paid one dollar for allowing her son to take part.

The "Little Albert" experiment went like this: Researchers first introduced the baby to a small, furry white rat, of which he initially had no fear . (According to reports, he didn't really show much interest at all). Then they re-introduced him to the rat while a loud sound rang out. Over and over, "Albert" was exposed to the rat and startling noises until he became frightened any time he saw any small, furry animal (rats, for sure, but also dogs and monkeys) regardless of noise.

Who exactly "Albert" was remained unknown until 2010, when his identity was revealed to be Douglas Merritte. Merritte, it turns out, wasn't a healthy subject: He showed signs of behavioral and neurological impairment, never learned to talk or walk, and only lived to age six, dying from hydrocephalus (water on the brain). He also suffered from a bacterial meningitis infection he may have acquired accidentally during treatments for his hydrocephalus, or, as some theorize, may have been -- horrifyingly -- intentionally infected as part of another experiment.

In the end, Merritte was never deconditioned, and because he died at such a young age no one knows if he continued to fear small furry things post-experiment.

7: The Monster Study of 1939

Today we understand that stuttering has many possible causes. It may run in some families, an inherited genetic quirk of the language center of the brain. It may also occur because of a brain injury, including stroke or other trauma. Some young children stutter when they're learning to talk, but outgrow the problem. In some rare instances, it may be a side effect of emotional trauma. But you know what it's not caused by? Criticism.

In 1939 Mary Tudor, a graduate student at the University of Iowa, and her faculty advisor, speech expert Wendell Johnson, set out to prove stuttering could be taught through negative reinforcement -- that it's learned behavior. Over four months, 22 orphaned children were told they would be receiving speech therapy, but in reality they became subjects in a stuttering experiment; only about half were actually stutterers, and none received speech therapy.

During the experiment the children were split into four groups:

Half of the stutterers were given negative feedback.
The other half of stutterers were given positive feedback.
Half of the non-stuttering group were all told they were beginning to stutterer and were criticized.
The other half of non-stutterers were praised.

The only significant impact the experiment had was on that third group; these kids, despite never actually developing a stutter, began to change their behavior, exhibiting low self-esteem and adopting the self-conscious behaviors associated with stutterers. And those who did stutter didn't cease doing so regardless of the feedback they received.

6: Stateville Penitentiary Malaria Study

It's estimated that between 60 to 65 percent of American soldiers stationed in the South Pacific during WWII suffered from a malarial infection at some point during their service. For some units the infection proved to be more deadly than the enemy forces were, so finding an effective treatment was a high priority [source: Army Heritage Center Foundation]. Safe anti-malarial drugs were seen as essential to winning the war.

Beginning in 1944 and spanning over the course of two years, more than 400 prisoners at the Stateville Penitentiary in Illinois were subjects in an experiment aimed at finding an effective drug against malaria . Prisoners taking part in the experiment were infected with malaria, and then treated with experimental anti-malarial treatments. The experiment didn't have a hidden agenda, and its unethical methodology didn't seem to bother the American public, who were united in winning WWII and eager to bring the troops home — safe and healthy. The intent of the experiments wasn't hidden from the subjects, who were at the time praised for their patriotism and in many instances given shorter prison sentences in return for their participation.

5: The Aversion Project in South Africa

If you were living during the apartheid era in South Africa, you lived under state-regulated racial segregation. If that itself wasn't difficult enough, the state also controlled your sexuality.

The South African government upheld strict anti-homosexual laws. If you were gay you were considered a deviant — and your homosexuality was also considered a disease that could be treated. Even after homosexuality ceased to be considered a mental illness and aversion therapy as a way to cure it debunked, psychiatrists and Army medical professionals in the South African Defense Force (SADF) continued to believe the outdated theories and treatments. In particular, aversion therapy techniques were used on prisoners and on South Africans who were forced to join the military under the conscription laws of the time.

At Ward 22 at 1 Military hospital in Voortrekkerhoogte, Pretoria, between 1969 and 1987 attempts were made to "cure" perceived deviants. Homosexuals, gay men and lesbians were drugged and subjected to electroconvulsive behavior therapy while shown aversion stimuli (same-sex erotic photos), followed by erotic photos of the opposite sex after the electric shock. When the technique didn't work (and it absolutely didn't), victims were then treated with hormone therapy, which in some cases included chemical castration. In addition, an estimated 900 men and women also underwent gender reassignment surgery when subsequent efforts to "reorient" them failed — most without consent, and some left unfinished [source: Kaplan ].

4: Milgram Shock Experiments

Ghostbuster Peter Venkman, who is seen in the fictional film conducting ESP/electro-shock experiments on college students, was likely inspired by social psychologist Stanley Milgram's famous series of shock experiments conducted in the early 1960s. During Milgram's experiments "teachers" — Americans recruited for a Yale study they thought was about memory and learning — were told to read lists of words to "learners" (actors, although the teachers didn't know that). Each person in the teacher role was instructed to press a lever that would deliver a shock to their "learner" every time he made a mistake on word-matching quizzes. Teachers believed the voltage of shocks increased with each mistake, and ranged from 15 to 450 possible volts; roughly two-thirds of teachers shocked learners to the highest voltage , continuing to deliver jolts at the instruction of the experimenter.

In reality, this wasn't an experiment about memory and learning; rather, it was about how obedient we are to authority. No shocks were actually given.

Today, Milgram's shock experiments continue to be controversial; while they're criticized for their lack of realism, others point to the results as important to how humans behave when under duress. In 2010 the results of Milgram's study were repeated — with about 70 percent of teachers obediently administering what they believed to be the highest voltage shocks to their learners.

3: CIA Mind-Control Experiments (Project MK-Ultra)

If you're familiar with "Men Who Stare at Goats" or "The Manchurian Candidate" then you know: There was a period in the CIA's history when they performed covert mind-control experiments. If you thought it was fiction, it wasn't.

During the Cold War the CIA started researching ways they could turn Americans into CIA-controlled "superagents," people who could carry out assassinations and who wouldn't be affected by enemy interrogations. Under what was known as the MK-ULTRA project, CIA researchers experimented on unsuspecting American (and Canadian) citizens by slipping them psychedelic drugs, including LSD , PCP and barbiturates, as well as additional — and additionally illegal — methods such as hypnosis, and, possibly, chemical, biological, and radiological agents. Universities participated, mostly as a delivery system, also without their knowledge. The U.S. Department of Veterans Affairs estimates 7,000 soldiers were also involved in the research, without their consent.

The project endured for more than 20 years, during which the agency spent about $20 million. There was one death tied to the project, although more were suspected; tin 1973 the CIA destroyed what records were kept.

2: Unit 731

Using biological warfare was banned by the Geneva Protocol in 1925, but Japan rejected the ban. If germ warfare was effective enough to be banned, it must work, military leaders believed. Unit 731 , a secret unit in a secret facility — publicly known as the Epidemic Prevention and Water Supply Unit — was established in Japanese-controlled Manchuria, where by the mid-1930s Japan began experimenting with pathogenic and chemical warfare and testing on human subjects. There, military physicians and officers intentionally exposed victims to infectious diseases including anthrax , bubonic plague, cholera, syphilis, typhus and other pathogens, in an effort to understand how they affected the body and how they could be used in bombs and attacks in WWII.

In addition to working with pathogens, Unit 731 conducted experiments on people, including — but certainly not limited to — dissections and vivisections on living humans, all without anesthesia (the experimenters believed using it would skew the results of the research).

Many of the subjects were Chinese civilians and prisoners of war, but also included Russian and American victims among others — basically, anyone who wasn't Japanese was a potential subject. Today it's estimated that about 100,000 people were victims within the facility, but when you include the germ warfare field experiments (such as reports of Japanese planes dropping plague-infected fleas over Chinese villages and poisoning wells with cholera) the death toll climbs to estimates closer to 250,000, maybe more.

Believe it or not, after WWII the U.S. granted immunity to those involved in these war crimes committed at Unit 731 as part of an information exchange agreement — and until the 1980s, the Japanese government refused to admit any of this even happened.

1: The Human Vivisections of Herophilus

Ancient physician Herophilus is considered the father of anatomy. And while he made significant discoveries during his practice, it's how he learned about internal workings of the human body that lands him on this list.

Herophilus practiced medicine in Alexandria, Egypt, and during the reign of the first two Ptolemaio Pharoahs was allowed, at least for about 30 to 40 years, to dissect human bodies, which he did, publicly, along with contemporary Greek physician and anatomist Erasistratus. Under Ptolemy I and Ptolemy II, criminals could be sentenced to dissection and vivisection as punishment, and it's said the father of anatomy not only dissected the dead but also performed vivisection on an estimated 600 living prisoners [source: Elhadi ].

Herophilus made great strides in the study of human anatomy — especially the brain , eyes, liver, circulatory system, nervous system and reproductive system, during a time in history when dissecting human cadavers was considered an act of desecration of the body (there were no autopsies conducted on the dead, although mummification was popular in Egypt at the time). And, like today, performing vivisection on living bodies was considered butchery.

Frequently Asked Questions

How have these experiments influenced current ethical standards in research, what protections are in place today to prevent similar unethical research on humans, lots more information, author's note.

There is no denying that involving living, breathing humans in medical studies have produced some invaluable results, but there's that one medical saying most of us know, even if we're not in a medical field: first do no harm (or, if you're fancy, primum non nocere).

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Ugly past of U.S. human experiments uncovered

Shocking as it may seem, U.S. government doctors once thought it was fine to experiment on disabled people and prison inmates. Such experiments included giving hepatitis to mental patients in Connecticut, squirting a pandemic flu virus up the noses of prisoners in Maryland, and injecting cancer cells into chronically ill people at a New York hospital.

Much of this horrific history is 40 to 80 years old, but it is the backdrop for a meeting in Washington this week by a presidential bioethics commission. The meeting was triggered by the government's apology last fall for federal doctors infecting prisoners and mental patients in Guatemala with syphilis 65 years ago.

U.S. officials also acknowledged there had been dozens of similar experiments in the United States — studies that often involved making healthy people sick.

An exhaustive review by The Associated Press of medical journal reports and decades-old press clippings found more than 40 such studies. At best, these were a search for lifesaving treatments; at worst, some amounted to curiosity-satisfying experiments that hurt people but provided no useful results.

Inevitably, they will be compared to the well-known Tuskegee syphilis study. In that episode, U.S. health officials tracked 600 black men in Alabama who already had syphilis but didn't give them adequate treatment even after penicillin became available.

These studies were worse in at least one respect — they violated the concept of "first do no harm," a fundamental medical principle that stretches back centuries.

"When you give somebody a disease — even by the standards of their time — you really cross the key ethical norm of the profession," said Arthur Caplan, director of the University of Pennsylvania's Center for Bioethics.

Attitude similar to Nazi experiments Some of these studies, mostly from the 1940s to the '60s, apparently were never covered by news media. Others were reported at the time, but the focus was on the promise of enduring new cures, while glossing over how test subjects were treated.

Attitudes about medical research were different then. Infectious diseases killed many more people years ago, and doctors worked urgently to invent and test cures. Many prominent researchers felt it was legitimate to experiment on people who did not have full rights in society — people like prisoners, mental patients, poor blacks. It was an attitude in some ways similar to that of Nazi doctors experimenting on Jews.

"There was definitely a sense — that we don't have today — that sacrifice for the nation was important," said Laura Stark, a Wesleyan University assistant professor of science in society, who is writing a book about past federal medical experiments.

The AP review of past research found:

A federally funded study begun in 1942 injected experimental flu vaccine in male patients at a state insane asylum in Ypsilanti, Mich., then exposed them to flu several months later. It was co-authored by Dr. Jonas Salk, who a decade later would become famous as inventor of the polio vaccine.

Some of the men weren't able to describe their symptoms, raising serious questions about how well they understood what was being done to them. One newspaper account mentioned the test subjects were "senile and debilitated." Then it quickly moved on to the promising results.

In federally funded studies in the 1940s, noted researcher Dr. W. Paul Havens Jr. exposed men to hepatitis in a series of experiments, including one using patients from mental institutions in Middletown and Norwich, Conn. Havens, a World Health Organization expert on viral diseases, was one of the first scientists to differentiate types of hepatitis and their causes.

A search of various news archives found no mention of the mental patients study, which made eight healthy men ill but broke no new ground in understanding the disease.

Researchers in the mid-1940s studied the transmission of a deadly stomach bug by having young men swallow unfiltered stool suspension. The study was conducted at the New York State Vocational Institution, a reformatory prison in West Coxsackie. The point was to see how well the disease spread that way as compared to spraying the germs and having test subjects breathe it. Swallowing it was a more effective way to spread the disease, the researchers concluded. The study doesn't explain if the men were rewarded for this awful task.
A University of Minnesota study in the late 1940s injected 11 public service employee volunteers with malaria, then starved them for five days. Some were also subjected to hard labor, and those men lost an average of 14 pounds. They were treated for malarial fevers with quinine sulfate. One of the authors was Ancel Keys, a noted dietary scientist who developed K-rations for the military and the Mediterranean diet for the public. But a search of various news archives found no mention of the study.
For a study in 1957, when the Asian flu pandemic was spreading, federal researchers sprayed the virus in the noses of 23 inmates at Patuxent prison in Jessup, Md., to compare their reactions to those of 32 virus-exposed inmates who had been given a new vaccine.
Government researchers in the 1950s tried to infect about two dozen volunteering prison inmates with gonorrhea using two different methods in an experiment at a federal penitentiary in Atlanta. The bacteria was pumped directly into the urinary tract through the penis, according to their paper.

The men quickly developed the disease, but the researchers noted this method wasn't comparable to how men normally got infected — by having sex with an infected partner. The men were later treated with antibiotics. The study was published in the Journal of the American Medical Association, but there was no mention of it in various news archives.

Though people in the studies were usually described as volunteers, historians and ethicists have questioned how well these people understood what was to be done to them and why, or whether they were coerced.

Victims for science Prisoners have long been victimized for the sake of science. In 1915, the U.S. government's Dr. Joseph Goldberger — today remembered as a public health hero — recruited Mississippi inmates to go on special rations to prove his theory that the painful illness pellagra was caused by a dietary deficiency. (The men were offered pardons for their participation.)

But studies using prisoners were uncommon in the first few decades of the 20th century, and usually performed by researchers considered eccentric even by the standards of the day. One was Dr. L.L. Stanley, resident physician at San Quentin prison in California, who around 1920 attempted to treat older, "devitalized men" by implanting in them testicles from livestock and from recently executed convicts.

Newspapers wrote about Stanley's experiments, but the lack of outrage is striking.

"Enter San Quentin penitentiary in the role of the Fountain of Youth — an institution where the years are made to roll back for men of failing mentality and vitality and where the spring is restored to the step, wit to the brain, vigor to the muscles and ambition to the spirit. All this has been done, is being done ... by a surgeon with a scalpel," began one rosy report published in November 1919 in The Washington Post.

Around the time of World War II, prisoners were enlisted to help the war effort by taking part in studies that could help the troops. For example, a series of malaria studies at Stateville Penitentiary in Illinois and two other prisons was designed to test antimalarial drugs that could help soldiers fighting in the Pacific.

It was at about this time that prosecution of Nazi doctors in 1947 led to the "Nuremberg Code," a set of international rules to protect human test subjects. Many U.S. doctors essentially ignored them, arguing that they applied to Nazi atrocities — not to American medicine.

The late 1940s and 1950s saw huge growth in the U.S. pharmaceutical and health care industries, accompanied by a boom in prisoner experiments funded by both the government and corporations. By the 1960s, at least half the states allowed prisoners to be used as medical guinea pigs.

But two studies in the 1960s proved to be turning points in the public's attitude toward the way test subjects were treated.

The first came to light in 1963. Researchers injected cancer cells into 19 old and debilitated patients at a Jewish Chronic Disease Hospital in the New York borough of Brooklyn to see if their bodies would reject them.

The hospital director said the patients were not told they were being injected with cancer cells because there was no need — the cells were deemed harmless. But the experiment upset a lawyer named William Hyman who sat on the hospital's board of directors. The state investigated, and the hospital ultimately said any such experiments would require the patient's written consent.

At nearby Staten Island, from 1963 to 1966, a controversial medical study was conducted at the Willowbrook State School for children with mental retardation. The children were intentionally given hepatitis orally and by injection to see if they could then be cured with gamma globulin.

Those two studies — along with the Tuskegee experiment revealed in 1972 — proved to be a "holy trinity" that sparked extensive and critical media coverage and public disgust, said Susan Reverby, the Wellesley College historian who first discovered records of the syphilis study in Guatemala.

'My back is on fire!' By the early 1970s, even experiments involving prisoners were considered scandalous. In widely covered congressional hearings in 1973, pharmaceutical industry officials acknowledged they were using prisoners for testing because they were cheaper than chimpanzees.

Holmesburg Prison in Philadelphia made extensive use of inmates for medical experiments. Some of the victims are still around to talk about it. Edward "Yusef" Anthony, featured in a book about the studies, says he agreed to have a layer of skin peeled off his back, which was coated with searing chemicals to test a drug. He did that for money to buy cigarettes in prison.

"I said 'Oh my God, my back is on fire! Take this ... off me!'" Anthony said in an interview with The Associated Press, as he recalled the beginning of weeks of intense itching and agonizing pain.

The government responded with reforms. Among them: The U.S. Bureau of Prisons in the mid-1970s effectively excluded all research by drug companies and other outside agencies within federal prisons.

As the supply of prisoners and mental patients dried up, researchers looked to other countries.

It made sense. Clinical trials could be done more cheaply and with fewer rules. And it was easy to find patients who were taking no medication, a factor that can complicate tests of other drugs.

Additional sets of ethical guidelines have been enacted, and few believe that another Guatemala study could happen today. "It's not that we're out infecting anybody with things," Caplan said.

Still, in the last 15 years, two international studies sparked outrage.

One was likened to Tuskegee. U.S.-funded doctors failed to give the AIDS drug AZT to all the HIV-infected pregnant women in a study in Uganda even though it would have protected their newborns. U.S. health officials argued the study would answer questions about AZT's use in the developing world.

The other study, by Pfizer Inc., gave an antibiotic named Trovan to children with meningitis in Nigeria, although there were doubts about its effectiveness for that disease. Critics blamed the experiment for the deaths of 11 children and the disabling of scores of others. Pfizer settled a lawsuit with Nigerian officials for $75 million but admitted no wrongdoing.

Last year, the U.S. Department of Health and Human Services' inspector general reported that between 40 and 65 percent of clinical studies of federally regulated medical products were done in other countries in 2008, and that proportion probably has grown. The report also noted that U.S. regulators inspected fewer than 1 percent of foreign clinical trial sites.

Monitoring research is complicated, and rules that are too rigid could slow new drug development. But it's often hard to get information on international trials, sometimes because of missing records and a paucity of audits, said Dr. Kevin Schulman, a Duke University professor of medicine who has written on the ethics of international studies.

Syphilis study These issues were still being debated when, last October, the Guatemala study came to light.

In the 1946-48 study, American scientists infected prisoners and patients in a mental hospital in Guatemala with syphilis, apparently to test whether penicillin could prevent some sexually transmitted disease. The study came up with no useful information and was hidden for decades.

Story: U.S. apologizes for Guatemala syphilis experiments

The Guatemala study nauseated ethicists on multiple levels. Beyond infecting patients with a terrible illness, it was clear that people in the study did not understand what was being done to them or were not able to give their consent. Indeed, though it happened at a time when scientists were quick to publish research that showed frank disinterest in the rights of study participants, this study was buried in file drawers.

"It was unusually unethical, even at the time," said Stark, the Wesleyan researcher.

"When the president was briefed on the details of the Guatemalan episode, one of his first questions was whether this sort of thing could still happen today," said Rick Weiss, a spokesman for the White House Office of Science and Technology Policy.

That it occurred overseas was an opening for the Obama administration to have the bioethics panel seek a new evaluation of international medical studies. The president also asked the Institute of Medicine to further probe the Guatemala study, but the IOM relinquished the assignment in November, after reporting its own conflict of interest: In the 1940s, five members of one of the IOM's sister organizations played prominent roles in federal syphilis research and had links to the Guatemala study.

So the bioethics commission gets both tasks. To focus on federally funded international studies, the commission has formed an international panel of about a dozen experts in ethics, science and clinical research. Regarding the look at the Guatemala study, the commission has hired 15 staff investigators and is working with additional historians and other consulting experts.

The panel is to send a report to Obama by September. Any further steps would be up to the administration.

Some experts say that given such a tight deadline, it would be a surprise if the commission produced substantive new information about past studies. "They face a really tough challenge," Caplan said.

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5 Unethical Medical Experiments Brought Out of the Shadows of History

Prisoners and other vulnerable populations often bore the brunt of unethical medical experimentation..

medical instruments on a table - shutterstock

Most people are aware of some of the heinous medical experiments of the past that violated human rights. Participation in these studies was either forced or coerced under false pretenses. Some of the most notorious examples include the experiments by the Nazis, the Tuskegee syphilis study, the Stanford Prison Experiment, and the CIA’s LSD studies.

But there are many other lesser-known experiments on vulnerable populations that have flown under the radar. Study subjects often didn’t — or couldn’t — give consent. Sometimes they were lured into participating with a promise of improved health or a small amount of compensation. Other times, details about the experiment were disclosed but the extent of risks involved weren’t.

This perhaps isn’t surprising, as doctors who conducted these experiments were representative of prevailing attitudes at the time of their work. But unfortunately, even after informed consent was introduced in the 1950s , disregard for the rights of certain populations continued. Some of these researchers’ work did result in scientific advances — but they came at the expense of harmful and painful procedures on unknowing subjects.

Here are five medical experiments of the past that you probably haven’t heard about. They illustrate just how far the ethical and legal guidepost, which emphasizes respect for human dignity above all else, has moved.

The Prison Doctor Who Did Testicular Transplants

From 1913 to 1951, eugenicist Leo Stanley was the chief surgeon at San Quentin State Prison, California’s oldest correctional institution. After performing vasectomies on prisoners, whom he recruited through promises of improved health and vigor, Stanley turned his attention to the emerging field of endocrinology, which involves the study of certain glands and the hormones they regulate. He believed the effects of aging and decreased hormones contributed to criminality, weak morality, and poor physical attributes. Transplanting the testicles of younger men into those who were older would restore masculinity, he thought.

Stanley began by using the testicles of executed prisoners — but he ran into a supply shortage. He solved this by using the testicles of animals, including goats and deer. At first, he physically implanted the testicles directly into the inmates. But that had complications, so he switched to a new plan: He ground up the animal testicles into a paste, which he injected into prisoners’ abdomens. By the end of his time at San Quentin, Stanley did an estimated 10,000 testicular procedures .

The Oncologist Who Injected Cancer Cells Into Patients and Prisoners

During the 1950s and 1960s, Sloan-Kettering Institute oncologist Chester Southam conducted research to learn how people’s immune systems would react when exposed to cancer cells. In order to find out, he injected live HeLa cancer cells into patients, generally without their permission. When patient consent was given, details around the true nature of the experiment were often kept secret. Southam first experimented on terminally ill cancer patients, to whom he had easy access. The result of the injection was the growth of cancerous nodules , which led to metastasis in one person.

Next, Southam experimented on healthy subjects , which he felt would yield more accurate results. He recruited prisoners, and, perhaps not surprisingly, their healthier immune systems responded better than those of cancer patients. Eventually, Southam returned to infecting the sick and arranged to have patients at the Jewish Chronic Disease Hospital in Brooklyn, NY, injected with HeLa cells. But this time, there was resistance. Three doctors who were asked to participate in the experiment refused, resigned, and went public.

The scandalous newspaper headlines shocked the public, and legal proceedings were initiated against Southern. Some in the scientific and medical community condemned his experiments, while others supported him. Initially, Southam’s medical license was suspended for one year, but it was then reduced to a probation. His career continued to be illustrious, and he was subsequently elected president of the American Association for Cancer Research.

The Aptly Named ‘Monster Study’

Pioneering speech pathologist Wendell Johnson suffered from severe stuttering that began early in his childhood. His own experience motivated his focus on finding the cause, and hopefully a cure, for stuttering. He theorized that stuttering in children could be impacted by external factors, such as negative reinforcement. In 1939, under Johnson’s supervision, graduate student Mary Tudor conducted a stuttering experiment, using 22 children at an Iowa orphanage. Half received positive reinforcement. But the other half were ridiculed and criticized for their speech, whether or not they actually stuttered. This resulted in a worsening of speech issues for the children who were given negative feedback.

The study was never published due to the multitude of ethical violations. According to The Washington Post , Tudor was remorseful about the damage caused by the experiment and returned to the orphanage to help the children with their speech. Despite his ethical mistakes, the Wendell Johnson Speech and Hearing Clinic at the University of Iowa bears Johnson's name and is a nod to his contributions to the field.

The Dermatologist Who Used Prisoners As Guinea Pigs

One of the biggest breakthroughs in dermatology was the invention of Retin-A, a cream that can treat sun damage, wrinkles, and other skin conditions. Its success led to fortune and fame for co-inventor Albert Kligman, a dermatologist at the University of Pennsylvania . But Kligman is also known for his nefarious dermatology experiments on prisoners that began in 1951 and continued for around 20 years. He conducted his research on behalf of companies including DuPont and Johnson & Johnson.

Kligman’s work often left prisoners with pain and scars as he used them as study subjects in wound healing and exposed them to deodorants, foot powders, and more for chemical and cosmetic companies. Dow once enlisted Kligman to study the effects of dioxin, a chemical in Agent Orange, on 75 inmates at Pennsylvania's Holmesburg Prison. The prisoners were paid a small amount for their participation but were not told about the potential side effects.

In the University of Pennsylvania’s journal, Almanac , Kligman’s obituary focused on his medical advancements, awards, and philanthropy. There was no acknowledgement of his prison experiments. However, it did mention that as a “giant in the field,” he “also experienced his fair share of controversy.”

The Endocrinologist Who Irradiated Prisoners

When the Atomic Energy Commission wanted to know how radiation affected male reproductive function, they looked to endocrinologist Carl Heller . In a study involving Oregon State Penitentiary prisoners between 1963 and 1973, Heller designed a contraption that would radiate their testicles at varying amounts to see what effect it had, particularly on sperm production. The prisoners also were subjected to repeated biopsies and were required to undergo vasectomies once the experiments concluded.

Although study participants were paid, it raised ethical issues about the potential coercive nature of financial compensation to prison populations. The prisoners were informed about the risks of skin burns, but likely were not told about the possibility of significant pain, inflammation, and the small risk of testicular cancer.

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The Most Terrifying Human Experiments In World History

Most of the time, scientific progress is a very positive thing: studies that add to the overall understanding of how the world works. It's an admirable goal, and in reasonable circumstances, arguing against that isn't the easiest thing.

Sometimes, the circumstances are less than reasonable, and the desire to learn and experiment starts to cross the line into the ethically and morally gray. The push toward progress can come with a pretty heavy cost, potentially hurting a lot of people in the process. Human experimentation typically falls along these lines, but even then, there are some projects throughout world history that stand out, and for the worst reasons. Harmful effects on health and dubious consent tend to be pretty common factors in many of the worst of these studies. However, their legacies can sometimes differ, with some achieving infamy while others have managed to slip through the cracks of history.

Similarities and differences aside, though, here are just a few of the most terrifying human experiments ever conducted.

Project 4.1

When it comes to human experiments, Project 4.1 is an odd one. While researchers might have had less of a hand in inflicting terrible circumstances on their subjects, there's still some dubious morality that's worth considering.

For some context, during the 1940s and 1950s, the U.S. used the Marshall Islands as a testing ground for nuclear weapons and research, but it's important to note that these aren't empty, abandoned islands. On the contrary, they'd been inhabited for a long time, yet American tests weren't exactly as carefully planned as you would hope. Even relatively contained tests began raining radiation down on the local population, and public health became a growing concern.

That's where Project 4.1 comes into play, and perhaps its official name — "The Study of Response of Human Beings Exposed to Significant Beta and Gamma Radiation Due to Fallout from High Yield Weapons" — can give some insight into just where the ethics get murky. In effect, the inhabitants of the Marshall Islands became test subjects of convenience, a way for scientists to see the unintended consequences of a mess they had made. None of the locals knew that they were involved in any study; all they knew was that they were being treated for vague illnesses that they were told little about. All the while, of course, they were also dealing with the effects of radiation poisoning — congenital disabilities as well as social tensions — all while their requests for help were largely brushed aside.

The Stanford Prison Experiment

When you think about awful human experiments, there's a pretty good chance that the Stanford Prison Experiment comes to mind, and that's not without good reason. After all, recreating the conditions of a prison, such that reality turns into some "Lord of the Flies" type of nightmare, is more than a little scary.

If you're unfamiliar with it, the Stanford Prison Experiment was a 1971 study conducted by Philip Zimbardo that took a group of male college students and had them simulate the conditions of Stanford County Prison (which was really the basement of the Stanford University Psychology Department). The participants were separated into two groups: prisoners were humiliated from the outset, and guards were put into positions of authority and power. And things quickly devolved from there. Guards began to assert their power through cruelty and both physical and psychological punishment; prisoners experienced deep depression on more than one occasion and, on another occasion, staged a total rebellion (which was meant with even harsher reprisals). The ethics were murky, and the experiment ended after six days despite being planned to last two weeks.

Discussions surrounding the Stanford Prison Experiment have only gotten even more complicated in the years since. From the start, it was likely flawed — selection bias came into play, and even then, some participants admitted to playing up their actions and responses precisely because they knew it was all fake. It's not the best grounds to draw any accurate conclusions.

[Featured image by Philip Zimbardo via Wikimedia Commons | Cropped and scaled | CC BY-SA 4.0 ]

To put it pretty simply, MK Ultra sounds a lot like "The Manchurian Candidate." The idea that Cold War-era communist countries were somehow brainwashing American soldiers overseas was, in fact, a very real concern. And so, naturally, the U.S. government decided to try and weaponize mind control themselves, with all of that research getting rolled up under the purview of MK Ultra .

The project was fairly wide reaching, including just about any experiment that had to do with psychological manipulation. Hypnosis was quite possibly the most tame method, especially considering that electro-shock therapy and exposure to radiation or mind-altering drugs were also on the table. What's more, the actual means by which these experiments were carried out were far from ethical. Participants in these studies often weren't fully aware of exactly what they were signing up for, and even if you were to look past the dubious consent, then you'd find that MK Ultra targeted specific groups. Prisoners and patients in mental hospitals were easy targets, and the stories of their experiences are harrowing — feeling like their bones were melting or losing their ability to understand they were human was just the start.

Unsurprisingly, all of this was done in secret, with the CIA denying they were capable of such things. But word began to get out in the early 1960s, with congressional hearings taking place in the 1970s. Ultimately, those hearings weren't too effective — CIA staff claimed not to remember, and files were very conveniently destroyed — so the exact details might be even worse than those the public is aware of.

Operation Midnight Climax

In 1955, you could easily find an unassuming little house in San Francisco, tucked away on Chestnut Street. Outwardly, there wasn't much you could say about it, but if you started to pull away the curtains, you'd find something much more sinister: This was actually the site of a CIA experiment, one called Operation Midnight Climax .

To be technical about things, Midnight Climax was just one part of MK Ultra, the CIA's wide-reaching experimentation surrounding mind control, but it was awful enough to build up a notoriety all its own. Specifically, it was meant to focus on a particular fascination with LSD, but the execution was hardly scientific. Sex workers were hired to lure unsuspecting victims to the house, and once there, these victims became unwitting subjects, dosed with LSD. Meanwhile, behind the two-way mirror, those in charge of the experiment would just sit and watch. All while apparently having a pretty good time.

The ethics behind this are obviously questionable for many reasons, but it gets even worse. George White — the man who was officially in charge — had intentions rather divorced from drug research: voyeurism. Sure, there were discussions of how to use sex to extract information and the like, but White clearly had more self-serving interests in mind. After all, according to the man himself: "Where else could a red-blooded American boy lie, kill, cheat, steal, rape, and pillage with the sanction and blessing of the All-Highest?" (via The San Francisco Chronicle ).

Nazi experiments

It doesn't need to be said that the Nazis committed plenty of atrocities during World War II (and that's putting it very lightly). But there was more to Nazi atrocities than death camps and gas chambers; the medical experiments were a horror show all their own.

Victims of Nazi science were often Jewish or Romani prisoners in concentration camps — usually those who were deemed unfit to work — and their torture was justified under the Nazi regime as being in search of a way to prove racial supremacy. Hardly an acceptable reason, and it was only made all the worse when you considered what the experiments were. Methods of mass sterilization were a popular area of study — awful for both the fact that said methods were actively tested on innocent victims, and the fact that the intentions were, effectively, genocidal. Work was also done when it came to research on disease, though that work was accomplished by knowingly infecting victims just to see what different cures might do. Then, there was also murder, just to have more bodies to study.

All of it was bad enough to ultimately lead to infamy. After all, it's hard not to think of Nazi experiments and not hear about Joseph Mengele (pictured), known literally as the "Angel of Death" and remembered primarily for his (often lethal) experiments on twins .

When it comes to human experimentation during World War II, the first thing to come to mind is most likely the inhumane science carried out by Nazi doctors. But for as bad as all of that was, Nazi Germany wasn't the only nation guilty of some very twisted experimentation in the 1940s; after all, Japan had Unit 731.

In short, Unit 731 was a secret research branch operating primarily out of regions of China under Japanese control. From its inception in 1938, it focused on testing what the human body could endure. And that meant a whole lot of different things, all of them terribly inhumane and often deadly. Chinese prisoners would sometimes find themselves the subjects of vivisections. The reason why? To see what their internal organs looked like before death. Others were the subjects of vicious frostbite tests, having their limbs frozen, then thawed out by whatever means their captors chose. And that was if their limbs hadn't been amputated for no real reason other than to see what happened. In other cases, victims were subjected to insane situations to see what their bodies could handle: starvation, dehydration, deadly G-forces in centrifuges, or just having large objects dropped on them. Then, there was also weapons testing, which included subjecting people to flamethrowers, bayonets, nerve agents, and exposure to X-ray radiation.

Thousands of people died in those experiments (though the exact statistic remains a mystery), and Unit 731 was kept a secret for decades.

The Aversion Project

Just speaking in general, the racial segregation instituted by apartheid in South Africa during the 20th century was a very obvious problem. But during that time, segregation and oppression were determined by more than just race, and looking to the South African military would find an example in the Aversion Project.

The Aversion Project was an attempt by the South African military to "cure" gay soldiers of their sexuality, and, honestly, the explanation as to why it was so twisted could almost end there. That said, the devil is truly in the details. Many gay men were forced into psychiatric care, where they were given so-called aversion therapy — usually electroshock therapy, in reality, using voltages that were so high they reportedly sent one victim's shoes flying. Not that electricity was the only method being tested — chemical castration, hormone therapy, and unwanted sex-change operations were also on the table and used in thousands of cases. Even outside of the horrific treatments, life in these hospitals hardly focused on healing, with armed guards patrolling the halls and drugs used liberally on all patients — Valium for everyone and a strange "truth drug" that doctors could freely use during interrogations. Far from a welcoming place.

Ultimately, the project was abandoned, and it's done nothing but leave a bitter legacy. The man in charge, Dr. Aubrey Levin, admitted to his failure but not to his human rights violations, and the project itself was just one facet of widespread homophobia at the time.

The Tuskegee Syphilis Study

doctor tending to patient tuskegee syphilis study

Syphilis is not something to be taken lightly. Fortunately, its cure is something that sounds very simple nowadays — just a shot of penicillin. So, you would hope there wouldn't be any real reason to deny anyone treatment, right?

Well, if you went back to 1932, you'd find an alarming answer to that question, because that was the start of the Tuskegee Syphilis Study. The point of the study was to track the progression of the disease in hundreds of Black men living in Alabama, which wasn't necessarily ill-intentioned at the outset, as syphilis still didn't have a cure. But come 1947, penicillin was the recognized cure for the disease, and that's where ethics began to turn murky. Physicians had the means to treat hundreds of infected patients, but they just didn't, all because the U.S. Public Health Service valued their experiment over human lives. Officials urged that the men involved in the study continue to receive little more than placebos as their conditions worsened — and that included blindness, insanity, and death on more than a few occasions.

Worse still? The study went on unimpeded for decades, and even upon investigators discovering it in the 1960s, the project was both allowed to continue and explicitly intended to continue until its subjects died. The project didn't come to an end until it was leaked to the public in 1972 — 40 years and over 100 deaths after its inception.

The Guatemala Syphilis Experiment

The Tuskegee Syphilis Study is notorious for good reason; denying treatment to a population simply in the pursuit of cold-hearted academic study with little regard for life is an obvious problem. But American officials took things even further during the lesser-known Guatemala Syphilis Experiment. This wasn't a denial of treatment but a calculated spread of disease.

With the discovery of penicillin as a cure for syphilis during the early 1940s, public health officials wondered at its efficacy and how best to employ it. By the middle of the decade, they'd devised a way to answer that question: building a hospital in Guatemala where they could treat people infected with diseases including syphilis and gonorrhea. But this was far from charity. Instead, they intentionally infected members of the local population — in some cases through the use of infected sex workers, and in other cases by directly injecting people with the disease (typically done to prisoners and patients in psychiatric hospitals). Of course, none of these people had any idea what was happening, nor could they consent to participating in a study that could, honestly, threaten their lives. While it's true that the aforementioned hospital provided treatment to the infected, it's hard to ignore the fact that, over the course of two years, well over a thousand people were affected in the process, including both young children and the elderly.

Radiation experiments

Radiation was a hot topic during the 1940s and 1950s, and understandably so. Scientists at the time had plenty of reasons to learn precisely how dangerous radiation was to the human body. But it's difficult to justify the lengths they went to, because their experiments involved a lot of human experimentation and little consent.

There are several different examples of this — the 1945 Vanderbilt Nutrition Study, for instance, in which hundreds of pregnant women were, without their knowledge, given drugs with traces of radioactive iron. And there was an experiment conducted around the same time in which schoolchildren were fed radioactive calcium, fully backed by the U.S. government.

Perhaps the most egregious, though, were the plutonium injection experiments. And the name tells you most of what you need to know, as researchers wanted to see how radioactive materials were absorbed by the human body. Around 30 supposedly terminally ill patients were unknowingly injected with radioactive plutonium, in some cases at doses far above the lethal limit or with plutonium isotopes that were known to be especially radioactive. Records of these injections were kept secret — very intentionally, to avoid the expected public outcry — and off of normal hospital charts. Consent was only given in, at best, one of those cases, and, to make the situation even more twisted, at least a handful of those patients weren't even terminally ill. One was a 2-year-old child who died less than a year after being injected.

Disturbing human experiments aren’t something the average person thinks too much about. Rather, the progress achieved in the last 150 years of human history is an accomplishment we’re reminded of almost daily. Achievements made in biomedicine and the f ield of psychology mean that we no longer need to worry about things like deadly diseases or masturbation as a form of insanity. For better or worse, we have developed more effective ways to gather information, treat skin abnormalities, and even kill each other. But what we are not constantly reminded of are the human lives that have been damaged or lost in the name of this progress. The following is a list of the 30 most disturbing human experiments in history.

30. The Tearoom Sex Study

Image Source Sociologist Laud Humphreys often wondered about the men who commit impersonal sexual acts with one another in public restrooms. He wondered why “tearoom sex” — fellatio in public restrooms — led to the majority of homosexual arrests in the United States. Humphreys decided to become a “watchqueen” (the person who keeps watch and coughs when a cop or stranger get near) for his Ph.D. dissertation at Washington University. Throughout his research, Humphreys observed hundreds of acts of fellatio and interviewed many of the participants. He found that 54% of his subjects were married, and 38% were very clearly neither bisexual or homosexual. Humphreys’ research shattered a number of stereotypes held by both the public and law enforcement.

29. Prison Inmates as Test Subjects

Image Source In 1951, Dr. Albert M. Kligman, a dermatologist at the University of Pennsylvania and future inventor of Retin-A, began experimenting on inmates at Philadelphia’s Holmesburg Prison. As Kligman later told a newspaper reporter, “All I saw before me were acres of skin. It was like a farmer seeing a field for the first time.” Over the next 20 years, inmates willingly allowed Kligman to use their bodies in experiments involving toothpaste, deodorant, shampoo, skin creams, detergents, liquid diets, eye drops, foot powders, and hair dyes. Though the tests required constant biopsies and painful procedures, none of the inmates experienced long-term harm.

28. Henrietta Lacks

Image Source In 1955, Henrietta Lacks, a poor, uneducated African-American woman from Baltimore, was the unwitting source of cells which where then cultured for the purpose of medical research. Though researchers had tried to grow cells before, Henrietta’s were the first successfully kept alive and cloned. Henrietta’s cells, known as HeLa cells, have been instrumental in the development of the polio vaccine, cancer research, AIDS research, gene mapping, and countless other scientific endeavors. Henrietta died penniless and was buried without a tombstone in a family cemetery. For decades, her husband and five children were left in the dark about their wife and mother’s amazing contribution to modern medicine.

27. Project QKHILLTOP

Image Source In 1954, the CIA developed an experiment called Project QKHILLTOP to study Chinese brainwashing techniques, which they then used to develop new methods of interrogation. Leading the research was Dr. Harold Wolff of Cornell University Medical School. After requesting that the CIA provide him with information on imprisonment, deprivation, humiliation, torture, brainwashing, hypnoses, and more, Wolff’s research team began to formulate a plan through which they would develop secret drugs and various brain damaging procedures. According to a letter he wrote, in order to fully test the effects of the harmful research, Wolff expected the CIA to “make available suitable subjects.”

26. Stateville Penitentiary Malaria Study

Image Source During World War II, malaria and other tropical diseases were impeding the efforts of American military in the Pacific. In order to get a grip, the Malaria Research Project was established at Stateville Penitentiary in Joliet, Illinois. Doctors from the University of Chicago exposed 441 volunteer inmates to bites from malaria-infected mosquitos. Though one inmate died of a heart attack, researchers insisted his death was unrelated to the study. The widely-praised experiment continued at Stateville for 29 years, and included the first human test of Primaquine, a medication still used in the treatment of malaria and Pneumocystis pneumonia.

25. Emma Eckstein and Sigmund Freud

Image Source Despite seeking the help of Sigmund Freud for vague symptoms like stomach ailments and slight depression, 27-year old Emma Eckstein was “treated” by the German doctor for hysteria and excessive masturbation, a habit then considered dangerous to mental health. Emma’s treatment included a disturbing experimental surgery in which she was anesthetized with only a local anesthetic and cocaine before the inside of her nose was cauterized. Not surprisingly, Emma’s surgery was a disaster. Whether Emma was a legitimate medical patient or a source of more amorous interest for Freud, as a recent movie suggests, Freud continued to treat Emma for three years.

24. Dr. William Beaumont and the Stomach

Image Source In 1822, a fur trader on Mackinac Island in Michigan was accidentally shot in the stomach and treated by Dr. William Beaumont. Despite dire predictions, the fur trader survived — but with a hole (fistula) in his stomach that never healed. Recognizing the unique opportunity to observe the digestive process, Beaumont began conducting experiments. Beaumont would tie food to a string, then insert it through the hole in the trader’s stomach. Every few hours, Beaumont would remove the food to observe how it had been digested. Though gruesome, Beaumont’s experiments led to the worldwide acceptance that digestion was a chemical, not a mechanical, process.

23. Electroshock Therapy on Children

Image Source In the 1960s, Dr. Lauretta Bender of New York’s Creedmoor Hospital began what she believed to be a revolutionary treatment for children with social issues — electroshock therapy. Bender’s methods included interviewing and analyzing a sensitive child in front of a large group, then applying a gentle amount of pressure to the child’s head. Supposedly, any child who moved with the pressure was showing early signs of schizophrenia. Herself the victim of a misunderstood childhood, Bender was said to be unsympathetic to the children in her care. By the time her treatments were shut down, Bender had used electroshock therapy on over 100 children, the youngest of whom was age three.

22. Project Artichoke

Image Source In the 1950s, the CIA’s Office of Scientific Intelligence ran a series of mind control projects in an attempt to answer the question “Can we get control of an individual to the point where he will do our bidding against his will and even against fundamental laws of nature?” One of these programs, Project Artichoke, studied hypnosis, forced morphine addiction, drug withdrawal, and the use of chemicals to incite amnesia in unwitting human subjects. Though the project was eventually shut down in the mid-1960s, the project opened the door to extensive research on the use of mind-control in field operations.

21. Hepatitis in Mentally Disabled Children

Image Source In the 1950s, Willowbrook State School, a New York state-run institution for mentally handicapped children, began experiencing outbreaks of hepatitis. Due to unsanitary conditions, it was virtually inevitable that these children would contract hepatitis. Dr. Saul Krugman, sent to investigate the outbreak, proposed an experiment that would assist in developing a vaccine. However, the experiment required deliberately infecting children with the disease. Though Krugman’s study was controversial from the start, critics were eventually silenced by the permission letters obtained from each child’s parents. In reality, offering one’s child to the experiment was oftentimes the only way to guarantee admittance into the overcrowded institution.

20. Operation Midnight Climax

Image Source Initially established in the 1950s as a sub-project of a CIA-sponsored, mind-control research program, Operation Midnight Climax sought to study the effects of LSD on individuals. In San Francisco and New York, unconsenting subjects were lured to safehouses by prostitutes on the CIA payroll, unknowingly given LSD and other mind-altering substances, and monitored from behind one-way glass. Though the safehouses were shut down in 1965, when it was discovered that the CIA was administering LSD to human subjects, Operation Midnight Climax was a theater for extensive research on sexual blackmail, surveillance technology, and the use of mind-altering drugs on field operations.

19. Study of Humans Accidentally Exposed to Fallout Radiation

Image Source The 1954 “Study of Response of Human Beings exposed to Significant Beta and Gamma Radiation due to Fall-out from High-Yield Weapons,” known better as Project 4.1, was a medical study conducted by the U.S. of residents of the Marshall Islands. When the Castle Bravo nuclear test resulted in a yield larger than originally expected, the government instituted a top secret study to “evaluate the severity of radiation injury” to those accidentally exposed. Though most sources agree the exposure was unintentional, many Marshallese believed Project 4.1 was planned before the Castle Bravo test. In all, 239 Marshallese were exposed to significant levels of radiation.

18. The Monster Study

Image Source In 1939, University of Iowa researchers Wendell Johnson and Mary Tudor conducted a stuttering experiment on 22 orphan children in Davenport, Iowa. The children were separated into two groups, the first of which received positive speech therapy where children were praised for speech fluency. In the second group, children received negative speech therapy and were belittled for every speech imperfection. Normal-speaking children in the second group developed speech problems which they then retained for the rest of their lives. Terrified by the news of human experiments conducted by the Nazis, Johnson and Tudor never published the results of their “Monster Study.”

17. Project MKUltra

Image Source Project MKUltra is the code name of a CIA-sponsored research operation that experimented in human behavioral engineering. From 1953 to 1973, the program employed various methodologies to manipulate the mental states of American and Canadian citizens. These unwitting human test subjects were plied with LSD and other mind-altering drugs, hypnosis, sensory deprivation, isolation, verbal and sexual abuse, and various forms of torture. Research occurred at universities, hospitals, prisons, and pharmaceutical companies. Though the project sought to develop “chemical […] materials capable of employment in clandestine operations,” Project MKUltra was ended by a Congress-commissioned investigation into CIA activities within the U.S.

16. Experiments on Newborns

Image Source In the 1960s, researchers at the University of California began an experiment to study changes in blood pressure and blood flow. The researchers used 113 newborns ranging in age from one hour to three days old as test subjects. In one experiment, a catheter was inserted through the umbilical arteries and into the aorta. The newborn’s feet were then immersed in ice water for the purpose of testing aortic pressure. In another experiment, up to 50 newborns were individually strapped onto a circumcision board, then tilted so that their blood rushed to their head and their blood pressure could be monitored.

15. The Aversion Project

Image Source In 1969, during South Africa’s detestable Apartheid era, thousands of homosexuals were handed over to the care of Dr. Aubrey Levin, an army colonel and psychologist convinced he could “cure” homosexuals. At the Voortrekkerhoogte military hospital near Pretoria, Levin used electroconvulsive aversion therapy to “reorientate” his patients. Electrodes were strapped to a patient’s upper arm with wires running to a dial calibrated from 1 to 10. Homosexual men were shown pictures of a naked man and encouraged to fantasize, at which point the patient was subjected to severe shocks. When Levin was warned that he would be named an abuser of human rights, he emigrated to Canada where he currently works at a teaching hospital.

14. Medical Experiments on Prison Inmates

Image Source Perhaps one benefit of being an inmate at California’s San Quentin prison is the easy access to acclaimed Bay Area doctors. But if that’s the case, then a downside is that these doctors also have easy access to inmates. From 1913 to 1951, Dr. Leo Stanley, chief surgeon at San Quentin, used prisoners as test subjects in a variety of bizarre medical experiments. Stanley’s experiments included sterilization and potential treatments for the Spanish Flu. In one particularly disturbing experiment, Stanley performed testicle transplants on living prisoners using testicles from executed prisoners and, in some cases, from goats and boars.

13. Sexual Reassignment

Image Source In 1965, Canadian David Peter Reimer was born biologically male. But at seven months old, his penis was accidentally destroyed during an unconventional circumcision by cauterization. John Money, a psychologist and proponent of the idea that gender is learned, convinced the Reimers that their son would be more likely to achieve a successful, functional sexual maturation as a girl. Though Money continued to report only success over the years, David’s own account insisted that he had never identified as female. He spent his childhood teased, ostracized, and seriously depressed. At age 38, David committed suicide by shooting himself in the head.

12. Effect of Radiation on Testicles

Image Source Between 1963 and 1973, dozens of Washington and Oregon prison inmates were used as test subjects in an experiment designed to test the effects of radiation on testicles. Bribed with cash and the suggestion of parole, 130 inmates willingly agreed to participate in the experiments conducted by the University of Washington on behalf of the U.S. government. In most cases, subjects were zapped with over 400 rads of radiation (the equivalent of 2,400 chest x-rays) in 10 minute intervals. However, it was much later that the inmates learned the experiments were far more dangerous than they had been told. In 2000, the former participants settled a $2.4 million class-action settlement from the University.

11. Stanford Prison Experiment

Image Source Conducted at Stanford University from August 14-20, 1971, the Stanford Prison Experiment was an investigation into the causes of conflict between military guards and prisoners. Twenty-four male students were chosen and randomly assigned roles of prisoners and guards. They were then situated in a specially-designed mock prison in the basement of the Stanford psychology building. Those subjects assigned to be guards enforced authoritarian measures and subjected the prisoners to psychological torture. Surprisingly, many of the prisoners accepted the abuses. Though the experiment exceeded the expectations of all of the researchers, it was abruptly ended after only six days.

10. Syphilis Experiments in Guatemala

Image Source From 1946 to 1948, the United States government, Guatemalan president Juan José Arévalo, and some Guatemalan health ministries, cooperated in a disturbing human experiment on unwitting Guatemalan citizens. Doctors deliberately infected soldiers, prostitutes, prisoners, and mental patients with syphilis and other sexually transmitted diseases in an attempt to track their untreated natural progression. Treated only with antibiotics, the experiment resulted in at least 30 documented deaths. In 2010, the United States made a formal apology to Guatemala for their involvement in these experiments.

9. Tuskegee Syphilis Study

Image Source In 1932, the U.S. Public Health Service began working with the Tuskegee Institute to track the natural progression of untreated syphilis. Six hundred poor, illiterate, male sharecroppers were found and hired in Macon County, Alabama. Of the 600 men, only 399 had previously contracted syphilis, and none were told they had a life threatening disease. Instead, they were told they were receiving free healthcare, meals, and burial insurance in exchange for participating. Even after Penicillin was proven an effective cure for syphilis in 1947, the study continued until 1972. In addition to the original subjects, victims of the study included wives who contracted the disease, and children born with congenital syphilis. In 1997, President Bill Clinton formally apologized to those affected by what is often called the “most infamous biomedical experiment in U.S. history.”

8. Milgram Experiment

In 1961, Stanley Milgram, a psychologist at Yale University, began a series of social psychology experiments that measured the willingness of test subjects to obey an authority figure. Conducted only three months after the start of the trial of German Nazi war criminal Adolf Eichmann, Milgram’s experiment sought to answer the question, “Could it be that Eichmann and his million accomplices in the Holocaust were just following orders?” In the experiment, two participants (one secretly an actor and one an unwitting test subject) were separated into two rooms where they could hear, but not see, each other. The test subject would then read a series of questions to the actor, punishing each wrong answer with an electric shock. Though many people would indicate their desire to stop the experiment, almost all subjects continued when they were told they would not be held responsible, or that there would not be any permanent damage.

7. Infected Mosquitos in Towns

In 1956 and 1957, the United States Army conducted a number of biological warfare experiments on the cities of Savannah, Georgia and Avon Park, Florida. In one such experiment, millions of infected mosquitos were released into the two cities, in order to see if the insects could spread yellow fever and dengue fever. Not surprisingly, hundreds of researchers contracted illnesses that included fevers, respiratory problems, stillbirths, encephalitis, and typhoid. In order to photograph the results of their experiments, Army researchers pretended to be public health workers. Several people died as a result of the research.

6. Human Experimentation in the Soviet Union

Beginning in 1921 and continuing for most of the 21st century, the Soviet Union employed poison laboratories known as Laboratory 1, Laboratory 12, and Kamera as covert research facilities of the secret police agencies. Prisoners from the Gulags were exposed to a number of deadly poisons, the purpose of which was to find a tasteless, odorless chemical that could not be detected post mortem. Tested poisons included mustard gas, ricin, digitoxin, and curare, among others. Men and women of varying ages and physical conditions were brought to the laboratories and given the poisons as “medication,” or part of a meal or drink.

5. Human Experimentation in North Korea

Image Source Several North Korean defectors have described witnessing disturbing cases of human experimentation. In one alleged experiment, 50 healthy women prisoners were given poisoned cabbage leaves — all 50 women were dead within 20 minutes. Other described experiments include the practice of surgery on prisoners without anesthesia, purposeful starvation, beating prisoners over the head before using the zombie-like victims for target practice, and chambers in which whole families are murdered with suffocation gas. It is said that each month, a black van known as “the crow” collects 40-50 people from a camp and takes them to an known location for experiments.

4. Nazi Human Experimentation

Image Source Over the course of the Third Reich and the Holocaust, Nazi Germany conducted a series of medical experiments on Jews, POWs, Romani, and other persecuted groups. The experiments were conducted in concentration camps, and in most cases resulted in death, disfigurement, or permanent disability. Especially disturbing experiments included attempts to genetically manipulate twins; bone, muscle, and nerve transplantation; exposure to diseases and chemical gasses; sterilization, and anything else the infamous Nazi doctors could think up. After the war, these crimes were tried as part of the Nuremberg Trial and ultimately led to the development of the Nuremberg Code of medical ethics.

3. Unit 731

Image Source From 1937 to 1945, the imperial Japanese Army developed a covert biological and chemical warfare research experiment called Unit 731. Based in the large city of Harbin, Unit 731 was responsible for some of the most atrocious war crimes in history. Chinese and Russian subjects — men, women, children, infants, the elderly, and pregnant women — were subjected to experiments which included the removal of organs from a live body, amputation for the study of blood loss, germ warfare attacks, and weapons testing. Some prisoners even had their stomachs surgically removed and their esophagus reattached to the intestines. Many of the scientists involved in Unit 731 rose to prominent careers in politics, academia, business, and medicine.

2. Radioactive Materials in Pregnant Women

Image Source Shortly after World War II, with the impending Cold War forefront on the minds of Americans, many medical researchers were preoccupied with the idea of radioactivity and chemical warfare. In an experiment at Vanderbilt University, 829 pregnant women were given “vitamin drinks” they were told would improve the health of their unborn babies. Instead, the drinks contained radioactive iron and the researchers were studying how quickly the radioisotope crossed into the placenta. At least seven of the babies later died from cancers and leukemia, and the women themselves experienced rashes, bruises, anemia, loss of hair and tooth, and cancer.

1. Mustard Gas Tested on American Military

Image Source In 1943, the U.S. Navy exposed its own sailors to mustard gas. Officially, the Navy was testing the effectiveness of new clothing and gas masks against the deadly gas that had proven so terrifying in the first World War. The worst of the experiments occurred at the Naval Research Laboratory in Washington. Seventeen and 18-year old boys were approached after eight weeks of boot camp and asked if they wanted to participate in an experiment that would help shorten the war. Only when the boys reached the Research Laboratory were they told the experiment involved mustard gas. The participants, almost all of whom suffered severe external and internal burns, were ignored by the Navy and, in some cases, threatened with the Espionage Act. In 1991, the reports were finally declassified and taken before Congress.

28. Prison Inmates as Test Subjects Henrietta Lacks 26. Project QKHILLTOP 25. Stateville Penitentiary Malaria Study Stateville Penitentiary Malaria Study: Primaquine 24. Emma Eckstein 23. Dr. William Beaumont Dr. William Beaumont 21. Electroshock Therapy on Children 21. Project Artichoke 20. Operation Midnight Climax 19. Study of Humans Accidentally Exposed to Fallout Radiation 18. The Monster Experiment 17. Project MKUltra 16. Experiments on Newborns 15. The Aversion Project 14. Medical Experiments on Prison Inmates 13. Sexual Reassignment 12. Effect of Radiation on Testicles 11. Stanford Prison Experiment 10. Syphilis Experiment in Guatemala 9. Tuskegee Syphilis Study 8. Milgram Experiment 7. Infected Mosquitos in Towns 6. Human Experimentation in the Soviet Union 5. Human Experimentation in North Korea 4. Nazi Human Experimentation 3. Unit 731 2. Radioactive Materials in Pregnant Women 1. Mustard Gas Tested on American Military

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The 10 Cruelest Human Experimentation Cases in History
Despite his many cruel human experiments, Yishii escaped prosecution. Wikimedia Commons. Dr. Shiro Ishii and Unit 731. During World War II, Imperial Japan committed a number of crimes against humanity. But perhaps few were crueler than the experiments that were conducted at Unit 731. Part of the Imperial Japanese Army, this was a super-secret ...
Unethical human experimentation in the United States
A subject of the Tuskegee syphilis experiment has his blood drawn, c. 1953.. Numerous experiments which were performed on human test subjects in the United States in the past are now considered to have been unethical, because they were performed without the knowledge or informed consent of the test subjects. [1] Such tests have been performed throughout American history, but have become ...
10 Outrageous Experiments Conducted on Humans
But before 1974 the ethics involved in using humans in research experiments was a little, let's say, loose. And the exploitation and abuse of human subjects was often alarming. We begin our list with one of the most famous instances of exploitation, a study that eventually helped change the public view about the lack of consent in the name of ...
Unethical human experimentation
Unethical human experimentation is human experimentation that violates the principles of medical ethics.Such practices have included denying patients the right to informed consent, using pseudoscientific frameworks such as race science, and torturing people under the guise of research. Around World War II, Imperial Japan and Nazi Germany carried out brutal experiments on prisoners and ...
13 Instances Of Unethical Human Experimentation Performed In The United
Although the research was "very public," his experiments were eventually condemned and exposed by Allen M. Hornblum, a former criminal justice official. 7. A 60 Minutes investigation uncovered unauthorized human experimentation done on institutionalized children at Sonoma State Hospital in northern California. From 1950 to 1960, children ...
Ugly past of U.S. human experiments uncovered
Last year, the U.S. Department of Health and Human Services' inspector general reported that between 40 and 65 percent of clinical studies of federally regulated medical products were done in ...
Human Experimentation: An Introduction to the Ethical Issues
The unethical military experiments during the Cold War would have been impossible if GIs had had the right to abort assignments or raise complaints. As we address the ethical issues of human experimentation, we often find ourselves traversing complex ethical terrain. Vigilance is most essential when vulnerable populations are involved.
5 Unethical Medical Experiments Brought Out of the Shadows of History
Most people are aware of some of the heinous medical experiments of the past that violated human rights. Participation in these studies was either forced or coerced under false pretenses. Some of the most notorious examples include the experiments by the Nazis, the Tuskegee syphilis study, the Stanford Prison Experiment, and the CIA's LSD ...
The Most Terrifying Human Experiments In World History
Similarities and differences aside, though, here are just a few of the most terrifying human experiments ever conducted. Advertisement. Project 4.1. Bettmann/Getty Images. When it comes to human experiments, Project 4.1 is an odd one. While researchers might have had less of a hand in inflicting terrible circumstances on their subjects, there's ...
30 Most Unethical Psychology Human Experiments
Stanley's experiments included sterilization and potential treatments for the Spanish Flu. In one particularly disturbing experiment, Stanley performed testicle transplants on living prisoners using testicles from executed prisoners and, in some cases, from goats and boars. 13. Sexual Reassignment