effects of exercise essay

Importance of Exercise Essay

500 words essay on exercise essay.

Exercise is basically any physical activity that we perform on a repetitive basis for relaxing our body and taking away all the mental stress. It is important to do regular exercise. When you do this on a daily basis, you become fit both physically and mentally. Moreover, not exercising daily can make a person susceptible to different diseases. Thus, just like eating food daily, we must also exercise daily. The importance of exercise essay will throw more light on it.

Importance of Exercise

Exercising is most essential for proper health and fitness. Moreover, it is essential for every sphere of life. Especially today’s youth need to exercise more than ever. It is because the junk food they consume every day can hamper their quality of life.

If you are not healthy, you cannot lead a happy life and won’t be able to contribute to the expansion of society. Thus, one needs to exercise to beat all these problems. But, it is not just about the youth but also about every member of the society.

These days, physical activities take places in colleges more than often. The professionals are called to the campus for organizing physical exercises. Thus, it is a great opportunity for everyone who wishes to do it.

Just like exercise is important for college kids, it is also essential for office workers. The desk job requires the person to sit at the desk for long hours without breaks. This gives rise to a very unhealthy lifestyle.

They get a limited amount of exercise as they just sit all day then come back home and sleep. Therefore, it is essential to exercise to adopt a healthy lifestyle that can also prevent any damaging diseases .

Benefits of Exercise

Exercise has a lot of benefits in today’s world. First of all, it helps in maintaining your weight. Moreover, it also helps you reduce weight if you are overweight. It is because you burn calories when you exercise.

Further, it helps in developing your muscles. Thus, the rate of your body will increases which helps to burn calories. Moreover, it also helps in improving the oxygen level and blood flow of the body.

When you exercise daily, your brain cells will release frequently. This helps in producing cells in the hippocampus. Moreover, it is the part of the brain which helps to learn and control memory.

The concentration level in your body will improve which will ultimately lower the danger of disease like Alzheimer’s. In addition, you can also reduce the strain on your heart through exercise. Finally, it controls the blood sugar levels of your body so it helps to prevent or delay diabetes.

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Conclusion of Importance of Exercise Essay

In order to live life healthily, it is essential to exercise for mental and physical development. Thus, exercise is important for the overall growth of a person. It is essential to maintain a balance between work, rest and activities. So, make sure to exercise daily.

FAQ of Importance of Exercise Essay

Question 1: What is the importance of exercise?

Answer 1: Exercise helps people lose weight and lower the risk of some diseases. When you exercise daily, you lower the risk of developing some diseases like obesity, type 2 diabetes, high blood pressure and more. It also helps to keep your body at a healthy weight.

Question 2: Why is exercising important for students?

Answer 2: Exercising is important for students because it helps students to enhance their cardiorespiratory fitness and build strong bones and muscles. In addition, it also controls weight and reduces the symptoms of anxiety and depression. Further, it can also reduce the risk of health conditions like heart diseases and more.

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• Importance Of Exercises Essay

Importance of Exercise Essay

500+ words essay on the importance of exercise.

We all know that exercise is extremely important in our daily lives, but we may not know why or what exercise can do. It’s important to remember that we have evolved from nomadic ancestors who spent all their time moving around in search of food and shelter, travelling large distances on a daily basis. Our bodies are designed and have evolved to be regularly active. Over time, people may come across problems if they sit down all day at a desk or in front of the TV and minimise the amount of exercise they do. Exercise is a bodily movement performed in order to develop or maintain physical fitness and good health overall. Exercise leads to the physical exertion of sufficient intensity, duration and frequency to achieve or maintain vigour and health. This essay on the importance of exercise will help students become familiar with the several benefits of doing exercise regularly. They must go through this essay so as to get an idea of how to write essays on similar topics.

Need of Exercise

The human body is like a complex and delicate machine which comprises several small parts. A slight malfunction of one part leads to the breakdown of the machine. In a similar way, if such a situation arises in the human body, it also leads to malfunctioning of the body. Exercise is one of the healthy lifestyles which contributes to optimum health and quality of life. People who exercise regularly can reduce their risk of death. By doing exercise, active people increase their life expectancy by two years compared to inactive people. Regular exercise and good physical fitness enhance the quality of life in many ways. Physical fitness and exercise can help us to look good, feel good, and enjoy life. Moreover, exercise provides an enjoyable way to spend leisure time.

Exercise helps a person develop emotional balance and maintain a strong self-image. As people get older, exercise becomes more important. This is because, after the age of 30, the heart’s blood pumping capacity declines at a rate of about 8 per cent each decade. Exercise is also vital for a child’s overall development. Exercising helps to maintain a healthy weight by stoking our metabolism, utilizing and burning the extra calories.

Types of Exercise

There are three broad intensities of exercise:

1) Light exercise – Going for a walk is an example of light exercise. In this, the exerciser is able to talk while exercising.

2) Moderate exercise – Here, the exerciser feels slightly out of breath during the session. Examples could be walking briskly, cycling moderately or walking up a hill.

3) Vigorous exercise – While performing this exercise, the exerciser is panting during the activity. The exerciser feels his/her body being pushed much nearer its limit compared to the other two intensities. This could include running, cycling fast, and heavy-weight training.

Importance of Exercise

Regular exercise increases our fitness level and physical stamina. It plays a crucial role in the prevention of cardiovascular diseases. It can help with blood lipid abnormalities, diabetes and obesity. Moreover, it can help to reduce blood pressure. Regular exercise substantially reduces the risk of dying of coronary heart disease and eases the risk of stroke and colon cancer. People of all age groups benefit from exercising.

Exercise can be effective in improving the mental well-being of human beings. It relieves human stress and anxiety. When we come back from work or school, we feel exhausted after a whole day of work. If we can go out to have a walk or jog for at least 30 minutes, it makes us feel happy and relaxed. A number of studies have found that a lifestyle that includes exercise helps alleviate depression. Those who can maintain regular exercise will also reduce their chances of seeing a doctor. Without physical activity, the body’s muscles lose their strength, endurance and ability to function properly. Regular exercise keeps all parts of the body in continuous activity. It improves overall health and fitness, as well as decreases the risk of many chronic diseases. Therefore, physical exercise is very important in our life.

Exercise can play a significant role in keeping the individual, society, community and nation wealthy. If the citizens of a country are healthy, the country is sure to touch heights in every facet of life. The country’s healthy generation can achieve the highest marks in various fields and thereby enable their country to win laurels and glory at the international level. The first step is always the hardest. However, if we can overcome it, and exercise for 21 days continuously, it will be a new beginning for a healthy life.

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Frequently Asked Questions on the Importance of Exercises Essay

What are the benefits of exercising regularly.

Regular exercise helps in the relaxation of the mind and body and keeps the body fit. It improves flexibility and blood circulation.

Which are some of the easy exercises that can be done at home?

Sit-ups, bicycle crunches, squats, lunges and planks are examples of easy exercises which can be done at home without the help of costly equipment.

Is cycling an effective form of exercise?

Cycling is a low-impact exercise and acts as a good muscle workout.

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Physical Activity Is Good for the Mind and the Body

Health and Well-Being Matter is the monthly blog of the Director of the Office of Disease Prevention and Health Promotion.

Everyone has their own way to “recharge” their sense of well-being — something that makes them feel good physically, emotionally, and spiritually even if they aren’t consciously aware of it. Personally, I know that few things can improve my day as quickly as a walk around the block or even just getting up from my desk and doing some push-ups. A hike through the woods is ideal when I can make it happen. But that’s me. It’s not simply that I enjoy these activities but also that they literally make me feel better and clear my mind.

Mental health and physical health are closely connected. No kidding — what’s good for the body is often good for the mind. Knowing what you can do physically that has this effect for you will change your day and your life.

Physical activity has many well-established mental health benefits. These are published in the Physical Activity Guidelines for Americans and include improved brain health and cognitive function (the ability to think, if you will), a reduced risk of anxiety and depression, and improved sleep and overall quality of life. Although not a cure-all, increasing physical activity directly contributes to improved mental health and better overall health and well-being.

Learning how to routinely manage stress and getting screened for depression are simply good prevention practices. Awareness is especially critical at this time of year when disruptions to healthy habits and choices can be more likely and more jarring. Shorter days and colder temperatures have a way of interrupting routines — as do the holidays, with both their joys and their stresses. When the plentiful sunshine and clear skies of temperate months give way to unpredictable weather, less daylight, and festive gatherings, it may happen unconsciously or seem natural to be distracted from being as physically active. However, that tendency is precisely why it’s so important that we are ever more mindful of our physical and emotional health — and how we can maintain both — during this time of year.

Roughly half of all people in the United States will be diagnosed with a mental health disorder at some point in their lifetime, with anxiety and anxiety disorders being the most common. Major depression, another of the most common mental health disorders, is also a leading cause of disability for middle-aged adults. Compounding all of this, mental health disorders like depression and anxiety can affect people’s ability to take part in health-promoting behaviors, including physical activity. In addition, physical health problems can contribute to mental health problems and make it harder for people to get treatment for mental health disorders.

The COVID-19 pandemic has brought the need to take care of our physical and emotional health to light even more so these past 2 years. Recently, the U.S. Surgeon General highlighted how the pandemic has exacerbated the mental health crisis in youth .

The good news is that even small amounts of physical activity can immediately reduce symptoms of anxiety in adults and older adults. Depression has also shown to be responsive to physical activity. Research suggests that increased physical activity, of any kind, can improve depression symptoms experienced by people across the lifespan. Engaging in regular physical activity has also been shown to reduce the risk of developing depression in children and adults.

Though the seasons and our life circumstances may change, our basic needs do not. Just as we shift from shorts to coats or fresh summer fruits and vegetables to heartier fall food choices, so too must we shift our seasonal approach to how we stay physically active. Some of that is simply adapting to conditions: bundling up for a walk, wearing the appropriate shoes, or playing in the snow with the kids instead of playing soccer in the grass.

Sometimes there’s a bit more creativity involved. Often this means finding ways to simplify activity or make it more accessible. For example, it may not be possible to get to the gym or even take a walk due to weather or any number of reasons. In those instances, other options include adding new types of movement — such as impromptu dance parties at home — or doing a few household chores (yes, it all counts as physical activity).

During the COVID-19 pandemic, I built a makeshift gym in my garage as an alternative to driving back and forth to the gym several miles from home. That has not only saved me time and money but also afforded me the opportunity to get 15 to 45 minutes of muscle-strengthening physical activity in at odd times of the day.

For more ideas on how to get active — on any day — or for help finding the motivation to get started, check out this Move Your Way® video .

The point to remember is that no matter the approach, the Physical Activity Guidelines recommend that adults get at least 150 minutes of moderate-intensity aerobic activity (anything that gets your heart beating faster) each week and at least 2 days per week of muscle-strengthening activity (anything that makes your muscles work harder than usual). Youth need 60 minutes or more of physical activity each day. Preschool-aged children ages 3 to 5 years need to be active throughout the day — with adult caregivers encouraging active play — to enhance growth and development. Striving toward these goals and then continuing to get physical activity, in some shape or form, contributes to better health outcomes both immediately and over the long term.

For youth, sports offer additional avenues to more physical activity and improved mental health. Youth who participate in sports may enjoy psychosocial health benefits beyond the benefits they gain from other forms of leisure-time physical activity. Psychological health benefits include higher levels of perceived competence, confidence, and self-esteem — not to mention the benefits of team building, leadership, and resilience, which are important skills to apply on the field and throughout life. Research has also shown that youth sports participants have a reduced risk of suicide and suicidal thoughts and tendencies. Additionally, team sports participation during adolescence may lead to better mental health outcomes in adulthood (e.g., less anxiety and depression) for people exposed to adverse childhood experiences. In addition to the physical and mental health benefits, sports can be just plain fun.

Physical activity’s implications for significant positive effects on mental health and social well-being are enormous, impacting every facet of life. In fact, because of this national imperative, the presidential executive order that re-established the President’s Council on Sports, Fitness & Nutrition explicitly seeks to “expand national awareness of the importance of mental health as it pertains to physical fitness and nutrition.” While physical activity is not a substitute for mental health treatment when needed and it’s not the answer to certain mental health challenges, it does play a significant role in our emotional and cognitive well-being.

No matter how we choose to be active during the holiday season — or any season — every effort to move counts toward achieving recommended physical activity goals and will have positive impacts on both the mind and the body. Along with preventing diabetes, high blood pressure, obesity, and the additional risks associated with these comorbidities, physical activity’s positive effect on mental health is yet another important reason to be active and Move Your Way .

As for me… I think it’s time for a walk. Happy and healthy holidays, everyone!

Yours in health, Paul

Paul Reed, MD Rear Admiral, U.S. Public Health Service Deputy Assistant Secretary for Health Director, Office of Disease Prevention and Health Promotion

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Essay on Benefits of Exercise

Students are often asked to write an essay on Benefits of Exercise in their schools and colleges. And if you’re also looking for the same, we have created 100-word, 250-word, and 500-word essays on the topic.

Let’s take a look…

100 Words Essay on Benefits of Exercise

Introduction.

Exercise is a vital part of our daily routine. It helps in maintaining our health, improving our mood, and enhancing our overall well-being.

Physical Health

Exercise strengthens our heart and lungs, reducing the risk of diseases. It helps in maintaining a healthy weight and promotes better sleep.

Mental Health

Regular exercise releases endorphins, chemicals that make us feel happier and relaxed. It also boosts our self-esteem and improves concentration.

In conclusion, exercise benefits us in many ways. It’s an excellent tool to stay healthy, happy, and focused. Therefore, we should include it in our daily routine.

250 Words Essay on Benefits of Exercise

Exercise, often underrated, is a potent tool for enhancing physical and mental health. It is a universal remedy that offers numerous benefits, transcending age, gender, and physical ability.

Physical Health Benefits

Exercise primarily enhances physical wellbeing. Regular physical activity strengthens the cardiovascular system, reducing the risk of heart diseases. It aids in maintaining a healthy weight, thus preventing obesity-related illnesses. Moreover, exercise improves bone density, reducing the risk of osteoporosis, and enhances muscular strength and flexibility, thereby preventing injuries.

Mental Health Benefits

Beyond physical health, exercise significantly contributes to mental wellbeing. It stimulates the production of endorphins, the body’s natural mood elevators, leading to reduced stress levels and increased happiness. Regular exercise can also alleviate symptoms of depression and anxiety, enhancing overall mental health.

Cognitive Benefits

Exercise also plays a crucial role in cognitive function. It promotes better sleep, aids in maintaining focus, and improves memory. Studies suggest that regular physical activity can delay the onset of cognitive decline in later years, reinforcing its long-term benefits.

In conclusion, the benefits of exercise are manifold, spanning physical, mental, and cognitive domains. It is a cost-effective, accessible strategy to enhance overall health and wellbeing. As college students, embracing exercise as a regular habit can significantly contribute to academic success and lifelong health. The adage, “A healthy mind in a healthy body,” indeed holds.

500 Words Essay on Benefits of Exercise

Exercise, often regarded as a panacea for numerous health-related issues, has been a subject of extensive research over the years. It is a powerful tool that aids in the enhancement of both physical and mental well-being. This essay aims to explore the multifaceted benefits of exercise, ranging from improved physical health to enhanced cognitive abilities.

In addition to cardiovascular health, exercise contributes to better respiratory health by enhancing lung capacity and efficiency. It also plays a crucial role in weight management, as it helps burn calories, preventing obesity and associated diseases like diabetes and certain types of cancer.

The benefits of exercise are not limited to physical health; they also extend to mental well-being. Regular physical activity has been shown to reduce symptoms of anxiety and depression. It stimulates the production of endorphins, often referred to as ‘feel-good’ hormones, which elevate mood and promote a sense of well-being.

Recent research has unveiled the cognitive benefits of regular exercise. It has been found to enhance memory and thinking skills. Exercise promotes the growth of new brain cells and improves connections between neurons, leading to better brain health. It can also slow down the cognitive decline associated with aging, thereby reducing the risk of diseases like Alzheimer’s and dementia.

Social Benefits

Exercise often serves as a social activity, providing opportunities to meet new people and strengthen relationships. Participating in group exercises or sports can foster a sense of community and belonging, which is crucial for emotional well-being. Moreover, it can also enhance teamwork and leadership skills, which are invaluable in various aspects of life.

If you’re looking for more, here are essays on other interesting topics:

Apart from these, you can look at all the essays by clicking here .

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• v.8(7); 2018 Jul

Health Benefits of Exercise

Gregory n. ruegsegger.

1 Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211

Frank W. Booth

2 Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri 65211

3 Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri 65211

4 Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211

Overwhelming evidence exists that lifelong exercise is associated with a longer health span, delaying the onset of 40 chronic conditions/diseases. What is beginning to be learned is the molecular mechanisms by which exercise sustains and improves quality of life. The current review begins with two short considerations. The first short presentation concerns the effects of endurance exercise training on cardiovascular fitness, and how it relates to improved health outcomes. The second short section contemplates emerging molecular connections from endurance training to mental health. Finally, approximately half of the remaining review concentrates on the relationships between type 2 diabetes, mitochondria, and endurance training. It is now clear that physical training is complex biology, invoking polygenic interactions within cells, tissues/organs, systems, with remarkable cross talk occurring among the former list.

The aim of this introduction is briefly to document facts that health benefits of physical activity predate its readers. In the 5th century BC, the ancient physician Hippocrates stated: “All parts of the body, if used in moderation and exercised in labors to which each is accustomed, become thereby healthy and well developed and age slowly; but if they are unused and left idle, they become liable to disease, defective in growth and age quickly.” However, by the 21st century, the belief in the value of exercise for health has faded so considerably, the lack of exercise now presents a major public health problem ( Fig. 1 ) ( Booth et al. 2012 ). Similarly, the lack of exercise was classified as an actual cause of chronic diseases and death ( Mokdad et al. 2004 ).

Simplistic overview of how physical activity can prevent the development of type 2 diabetes and one of its complications, cardiovascular disease. Physical inactivity is an actual cause of type 2 diabetes, cardiovascular disease, and tens of other chronic conditions ( Table 1 ) via interaction with other factors (e.g., age, diet, gender, and genetics) to increase disease risk factors. This leads to chronic disease, reduced quality of life, and premature death. However, physical activity can prevent and, in some cases, treat disease progression associated with physical inactivity and other genetic and environmental factors.

Published in 1953, Jeremy N. Morris and colleagues conducted the first rigorous epidemiological study investigating physical activity and chronic disease risk, in which coronary heart disease (CHD) rates were increased in physically inactive bus drivers versus active conductors ( Morris et al. 1953 ). Since this pioneering report, a plethora of evidence shows that physical inactivity is associated with the development of 40 chronic diseases ( Table 1 ), including major noncommunicable diseases such as type 2 diabetes (T2D) and CHD, and as premature mortality ( Booth et al. 2012 ).

Worsening of 40 conditions caused by the lack of physical activity with growth, maturation, and aging throughout life span

The breadth of the list implies that a single molecular target will not substitute for appropriate daily physical activity to prevent the loss of all listed items.

In this review, we highlight the far-reaching health benefits of physical activity. However, note that the studies cited here represent only a fraction of the >100,000 studies showing positive associations between the terms “exercise” and “health.” In addition, we discuss how exercise promotes complex integrative responses that lead to multisystem responses to exercise, an underappreciated area of medical research. Finally, we consider how strategies that “mimic” parts of exercise training compare with physical exercise for their potential to combat metabolic disease.

EXERCISE IMPROVES CARDIORESPIRATORY FITNESS

There is arguably no measure more important for health than cardiorespiratory fitness (CRF) (commonly measured by maximal oxygen uptake, VO 2max ) ( Blair et al. 1989 ). For example, Myers et al. (2002 ) showed that each 1 metabolic equivalent (1 MET) increase in exercise-test performance conferred a 12% improvement in survival, stating that “VO 2max is a more powerful predictor of mortality among men than other established risk factors for cardiovascular disease (CVD).” Low CRF is also well established as an independent risk factor of T2D ( Booth et al. 2002 ) and CVD morbidity and mortality ( Kodama et al. 2009 ; Gupta et al. 2011 ). Similarly, Kokkinos et al. (2010) reported that men who transitioned from having low to high CRF decreased their mortality risk by ∼50% over an 8-yr period, whereas men who transitioned from having high to low CRF increased their mortality risk by ∼50%.

Importantly then, from the above paragraph, physical activity and inactivity are major environmental modulators of CRF, increasing and decreasing it, respectively, often through independent pathways. Findings from rats selectively bred for high or low intrinsic aerobic capacity show that rats bred for high capacity, which are also more physically active, have 28%–42% increases in life span compared to low-capacity rats ( Koch et al. 2011 ). Endurance exercise is well recognized to improve CRF and cardiometabolic risk factors. Exercise improves numerous factors speculated to limit VO 2max including, but not restricted to, the capacity to transport oxygen (e.g., cardiac output), oxygen diffusion to working muscles (e.g., capillary density, membrane permeability, muscle myoglobin content), and adenosine triphosphate (ATP) generation (e.g., mitochondrial density, protein concentrations).

Data from the HERITAGE Family Study has provided some of the first knowledge of genes associated with VO 2max plasticity because of endurance-exercise training. Following 6 wk of cycling training at 70% of pretraining VO 2max , Timmons et al. (2010) performed messenger RNA (mRNA) expression microarray profiling to identify molecules potentially predicting VO 2max training responses, and then assessed these molecular predictors to determine whether DNA variants in these genes correlated with VO 2max training responses. This approach identified 29 mRNAs in skeletal muscle and 11 single-nucleotide polymorphisms (SNPs) that predicted ∼50% and ∼23%, respectively, of the variability in VO 2max plasticity following aerobic training ( Timmons et al. 2010 ). Intriguingly, pretraining levels of these mRNAs were greater in subjects that achieved greater increases in VO 2max following aerobic training, and of the 29 mRNAs, >90% were unchanged with aerobic training, suggesting that alternative exercise intervention paradigms or pharmacological strategies may be needed to improve VO 2max in individuals with a low responder profile for the identified predictor genes ( Timmons et al. 2010 ). Keller et al. (2011) found that, in response to endurance training, improvements in VO 2max were associated with effectively up-regulating proangiogenic gene networks and miRNAs influencing the transcription factor–directed networks for runt-related transcription factor 1 (RUNX1), paired box gene 3 (PAC3), and sex-determining region Y box 9 (SOX9). Collectively, these results led the investigators to speculate that improvements in skeletal muscle oxygen sensing and angiogenesis are primary determinates in training responses in VO 2max ( Keller et al. 2011 ).

Clinically important concepts have emerged from the pioneering HERITAGE Family Study. One new clinical concept is that a threshold dose–response relationship influences the percentage of subjects responding with an increase in VO 2max to endurance training volumes (with volume being defined here as the product of intensity × duration), as previously published ( Slentz et al. 2005 , 2007 ). Ross et al. (2015) later extended the aforementioned Slentz et al. studies. After a 24-wk-long endurance training study ( Ross et al. 2015 ), percentages of women and men identified as nonresponders to the training (i.e., defined as not increasing their VO 2peak ) progressively fell inversely to a two stepwise progressive increase in endurance-exercise training volume, as described next. Thirty-nine percent (15 of 39) of training subjects did not increase their VO 2peak in response to the low-amount, low-intensity training; 18% (9 of 51) had no increase in VO 2peak in the group having high-amount, low-intensity training; and 0% (0 of 31) who underwent high-amount, high-intensity training did not increase their VO 2peak . A biological basis for the dose–response relationship in the previous sentence could be made from an analysis of interval training (IT) and IT/continuous-training studies published from 1965 to 2012 ( Bacon et al. 2013 ). A second older concept is being reinvigorated; Bacon et al. (2013) indicate that different endurance-exercise intensities and durations are needed for different systems in the body. They suggest that very short periods of high-intensity endurance-type exercise may be needed to reach a threshold for peripheral metabolic adaptations, but that longer training durations at lower intensities are required to see large changes in maximal cardiac output and VO 2max .

A comparable example exists for resistance training. Maximal resistance loads require a minimum of 2 min/per wk for each muscle group recruited by a specific maneuver to obtain a strength training adaptation [(8 contractions/set × 2 sec/contraction × 3 sets/day) × 2 days/wk) = 96 sec]. As of 2016, one opinion from Sarzynski et al. (2016) for the molecular mechanisms by which endurance exercise drives VO 2max include, but are not limited to, calcium signaling, energy sensing and partitioning, mitochondrial biogenesis, angiogenesis, immune functions, and regulation of autophagy and apoptosis.

Perhaps more importantly, lifelong aerobic exercise training preserves VO 2max into old age. CRF generally increases until early adulthood, then declines the remainder of life in sedentary humans ( Astrand 1956 ). The age-related decline in VO 2max is not trivial, as Schneider (2013) reported a ∼40% decline in healthy males and females spanning from 20 to 70 yr of age. However, cross-sectional data show that with lifelong aerobic exercise training, trained individuals often have the same VO 2max as a sedentary individual four decades younger ( Booth et al. 2012 ). Myers et al. (2002) found that low estimated VO 2max increases mortality 4.5-fold compared to high estimated VO 2max . They concluded, “Exercise capacity is a more powerful predictor of mortality among men than other established risk factors for cardiovascular disease.” Given the strong association between CRF, chronic disease, and mortality, we feel identifying the molecular transducers that cause age-related reductions in CRF may have profound implications for improving health span and delaying the onset of chronic disease. In two of our recent papers, transcriptomics was performed on the triceps muscle ( Toedebusch et al. 2016 ) and on the cardiac left ventricle ( Ruegsegger et al. 2017 ). We were addressing the question of what molecule initiates the beginning of the lifelong decline in aerobic capacity with aging. Aerobic capacity (VO 2max ) involves, at a minimum, the next systems/tissues, as oxygen travels through the mouth, airways, pulmonary membrane, pulmonary circulation, left heart, aorta/arteries/capillaries, and sarcoplasm/myoglobin to mitochondria. We allowed female rats access, or no access, to running wheels from 5 to 27 wk of age. Surprisingly, voluntary running had no effect on the delay in the beginning of the lifetime decrease in VO 2max . Our skeletal muscle transcriptomics elicited no molecular targets, whereas gene networks suggestive of influencing maximal stroke volume were identified in the left ventricle transcriptomics ( Ruegsegger et al. 2017 ).

Publications concerning the effects of exercise on the brain (from 54 to 216 papers listed on PubMed from 2007 to 2016) have increased 400%. In addition, a 2016 study ( Schuch et al. 2016 ) of three previous papers reported that humans with low- and moderate-CRF had 76% and 23%, respectively, increased risk of developing depression compared to high CRF in three publications. With this forming trend, the next section will consider exercise and brain health.

EXERCISE IMPROVES MENTAL HEALTH

Many studies support physical activity as a noninvasive therapy for mental health improvements in cognition ( Beier et al. 2014 ; Bielak et al. 2014 ; Tian et al. 2014 ), depression ( Kratz et al. 2014 ; McKercher et al. 2014 ; Mura et al. 2014 ), anxiety ( Greenwood et al. 2012 ; Nishijima et al. 2013 ; Schoenfeld et al. 2013 ), neurodegenerative diseases (i.e., Alzheimer’s and Parkinson’s disease) ( Bjerring and Arendt-Nielsen 1990 ; Mattson 2014 ), and drug addiction ( Zlebnik et al. 2012 ; Lynch et al. 2013 ; Peterson et al. 2014 ). In 1999, van Praag et al. (1999) showed the survival of newborn cells in the adult mouse dentate gyrus, a hippocampal region important for spatial recognition, is enhanced by voluntary wheel running. Similarly, spatial pattern separation and neurogenesis in the dentate gyrus are strongly correlated in 3-mo-old mice following 10 wk of voluntary wheel running ( Creer et al. 2010 ), and the development of new neurons in the dentate gyrus is coupled with the formation of new blood vessels ( Pereira et al. 2007 ). Many exercise-related improvements in cognitive function have been associated with local and systemic expression of growth factors in the hippocampus, notably, brain-derived neurotrophic factor (BDNF) ( Neeper et al. 1995 ; Cotman and Berchtold 2002 ). BDNF promotes many developmental functions in the brain, including neuronal cell survival, differentiation, migration, dendritic arborization, and synaptic plasticity ( Park and Poo 2013 ). In rat hippocampus, regular exercise promotes a progressive increase in BDNF protein for up to at least 3 mo ( Berchtold et al. 2005 ). In an opposite manner, BDNF mRNA in the hippocampus is rapidly decreased by the cessation of wheel running, suggesting BDNF expression is tightly related to exercise volume ( Widenfalk et al. 1999 ).

Findings by Wrann et al. (2013) highlight one mechanism by which endurance exercise may up-regulate BDNF expression. To summarize, Wrann et al. (2013) noted that exercise increases the activity of the estrogen-related receptor α (ERRα)/peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) complex, in turn increasing levels of the exercise-secreted factor FNDC5 in skeletal muscle and the hippocampus, whose cleavage products provide beneficial effects in the hippocampus by increasing BDNF gene expression. While future research should determine whether the FNDC5 cleavage-product was produced locally in hippocampal neurons or was secreted into the circulation, this finding eloquently displays one mechanism responsible for brain health benefits following exercise. Similarly, work by van Praag and colleagues suggests that exercise or pharmacological activation of AMP-activated protein kinase (AMPK) in skeletal muscle enhances indices of learning and memory, neurogenesis, and gene expression related to mitochondrial function in the hippocampus ( Kobilo et al. 2011 , 2014 ; Guerrieri and van Praag 2015 ).

Insulin-like growth factor 1 (IGF-1), is central to many exercise-induced adaptations in the brain. Like BDNF, physical activity increases circulatory IGF-1 levels and both exercise and infusion of IGF-1 increase BrdU + cell number and survivability in the hippocampus ( Trejo et al. 2001 ). Similarly, the protective effects of exercise on various brain lesions are nullified by anti-IGF-1 antibody ( Carro et al. 2001 ).

In 1979, Greist et al. (1979) provided evidence that running reduced depression symptoms similarly to psychotherapy. However, the precise mechanisms by which exercise prevents and/or treats depression remain largely unknown. Of the proposed mechanisms, increases in the availability of brain neurotransmitters and neurotrophic factors (e.g., BDNF, dopamine, glutamate, norepinephrine, serotonin) are perhaps the best studied. For example, tyrosine hydroxylase (TH) activity, the rate-limiting enzyme in dopamine formation, in the striatum, an area of the brain's reward system, is increased following 7 days of treadmill running in an intensity-dependent manner ( Hattori et al. 1994 ). Voluntary wheel running is also highly rewarding in rats, and voluntary wheel running in rats lowers the motivation to self-administer cocaine, suggesting exercise may be a viable strategy in the fight against drug addiction ( Larson and Carroll 2005 ).

Similar to the above examples, secreted factors from skeletal muscle have been linked to the regulation of depression. Agudelo et al. (2014) showed that exercise training in mice and humans, and overexpression of skeletal muscle PGC-1α1, leads to robust increases in kynurenine amino transferase (KAT) expression in skeletal muscle, an enzyme whose activity protects from stress-induced increases in depression in the brain by converting kynurenine into kynurenic acid. Additionally, overexpression of PGC-1α1 in skeletal muscle left mice resistant to stress, as evaluated by various behavioral assays indicative of depression ( Agudelo et al. 2014 ). Simultaneously, they report gene expression related to synaptic plasticity in the hippocampus, such as BDNF and CamkII, were unaffected by chronic mild stress compared to wild-type mice. Collectively, these findings suggest exercise-induced increases in skeletal muscle PGC-1α1 may be an important regulator of KAT expression in skeletal muscle, which, via modulation in plasma kynurenine levels, may alleviate stress-induced depression and promote hippocampal neuronal plasticity.

TYPE 2 DIABETES, MITOCHONDRIA, AND EXERCISE

T2d predictions show a pandemic.

In a 2001 Diabetes Care article ( Boyle et al. 2001 ), investigators at the U.S. Centers for Disease Control (CDC) predicted 29 million U.S. cases of T2D would be present in 2050. Unfortunately, the 2001 prediction of 29 million was reached in 2012! For 2012, the American Diabetes Association reported that 29 million Americans had diagnosed and undiagnosed T2D, which was 9% of the American population ( Dwyer-Lindgren et al. 2016 ). More rapid increases in T2D are now predicted by the CDC than in the previous estimate. The CDC now predicts a doubling or tripling in T2D in 2050. The tripling would mean that one out of three U.S. adults would have T2D in their lifetime by 2050 ( Boyle et al. 2010 ), which would be >100 million U.S. cases. The International Diabetes Federation (IDF) reports T2D cases worldwide. In 2015, the IDF reported that 344 and 416 million North American (including Caribbean) and worldwide adults, respectively, had T2D. Furthermore, the IDF predicts for 2040 that 413 and 642 million, respectively, will have T2D. In sum, T2D is now pandemic, and the pandemic will increase in numbers without current apparent action within the general public.

Type 2 Diabetes Prevalence Is Based on a Strong Genetic Predisposition

The Framingham study found that T2D risk in offspring was 3.5-fold and sixfold higher for a single and two diabetic parent(s), respectively, as compared to nondiabetic offspring ( Meigs et al. 2000 ). Thus, T2D is gene-based.

Noncoding regions of the human genome contain >90% of the >100 variants associated with both T2D and related traits that were observed in genome-wide association studies ( Scott et al. 2016 ). Another 2016 paper ( Kwak and Park 2016 ) lists at least 75 independent genetic loci that are associated with T2D. Taken together, T2D is a complex genetic disease ( Scott et al. 2016 ).

Type 2 Diabetes Is Modulated by Lifestyle, with Exercise as the More Powerful Lifestyle Factor

Three large-scale epidemiological studies have been performed on prediabetics, each in a different geographical location. The first study, and only study to have separate study arms for diet and exercise, was in China. The pure exercise intervention group had a 46% reduction in the onset of T2D, relative to the nontreated group, after 6 yr of the study ( Pan et al. 1997 ). Diet alone reduced T2D by 31% in the Chinese study. The second study on T2D was the Finnish Diabetes Prevention Study. It found a 58% reduction in T2D in the lifestyle intervention (combined diet and exercise) in its 522 prediabetic subjects after a mean study duration of 3.2 yr ( Tuomilehto et al. 2001 ). The latest of the three studies was in the U.S. Diabetes Prevention Program. The large randomized trial ( n = 3150 prediabetics) was stopped after 2.8 yr, because of harm to the control group. T2D prevalence in the high-risk adults was reduced by 58% with intensive lifestyle (diet and exercise) intervention, whereas the drug arm (metformin) of the study only reduced T2D by 31%, both compared to the noninnervation group ( Knowler et al. 2002 ). Thus, if differences in genetics in the above three differing ethnicities are not a factor, combined exercise and diet remain more effective in T2D prevention than the drug metformin two decades ago.

Exercise Increases Glucose by Signaling Independent of the Insulin Receptor

A single exercise bout increases glucose uptake by skeletal muscle, sidestepping the insulin receptor and thus insulin resistance in T2D patients ( Holloszy and Narahara 1965 ; Goodyear and Kahn 1998 ; Holloszy 2005 ). After insulin binding to its receptor, insulin initiates a downstream signaling cascade of tyrosine autophosphorylation of insulin receptor, insulin receptor substrate 1 (IRS-1) binding and phosphorylation, activation of a PI3K-dependent pathway, including key downstream regulators protein kinase B (Akt) and the Akt substrate of 160 kDa (AS160), ultimately promoting glucose transporter 4 (GLUT4) translocation to the plasma membrane ( Rockl et al. 2008 ; Stanford and Goodyear 2014 ). Despite normal GLUT4 levels, insulin fails to induce GLUT4 translocation in T2D ( Zierath et al. 2000 ). However, exercise activates a downstream insulin-signaling pathway at AS160 and TBC1 domain family member 1 (TBC1D1) ( Deshmukh et al. 2006 ; Maarbjerg et al. 2011 ), facilitating GLUT4 expression translocation to the plasma membrane independent of the insulin receptor. We contend that exercise could be considered as a very powerful tool to primarily attenuate the T2D pandemic.

Complex Biology of T2D Interactions with the Complex Biology of Exercise

An important consideration from the above is that T2D is such a genetically complex disease that a single gene has not been proven to be sufficiently causal to be effective, at this stage in time, to be a successful target for pharmacological treatment. The expectation for a single molecule target has been met for infectious diseases, which are often monogenic diseases. For example, a vaccine against smallpox was highly successful. Edward Jenner in 1796 produced the first successful vaccine. An important fact is that exercise is genetically complex. The literature allows us to speculate that exercise is at least as genetically complex as the approximately 75 genes associated with T2D ( Kwak and Park 2016 ). An example indicating that exercise is complex biology follows. RNA sequencing analysis of all 119 vastus lateralis muscle biopsies found that endurance training for 4 days/wk for 12 wk produced the differential expression of 3404 putative isoforms, belonging to 2624 different genes, many associated with oxidative ATP production in 23 women and men aged 29 yr old ( Lindholm et al. 2016 ). Our notion is that over 2600 genes suggests complex biology.

A “Case-Type” Study of the Molecular Underpinnings of Exercise, Mitochondria, and T2D Interactions

A PubMed search for the terms “diabetes mitochondria exercise molecular” elicited 74 papers. We arbitrarily selected some of the most recent 50 (spanning from mid-2014 into January 2017), with the assumption they would be representative of any other papers that we did not find in our search. Papers fell into our two arbitrary categories of single gene studies versus “omic”-type studies. First, subcategories of studies that develop themes will be arbitrarily presented.

Recent Studies Show Single Gene Manipulation Alters Mitochondrial Level and Running Performance

Numerous reports in the past couple of years observed that single gene manipulations increase mitochondrial gene expression and activity, which was also associated with increased exercise performance/capacity. A few of these are presented below:

• Irisin was shown to increase oxidative metabolism in myocytes and increase PGC-1α mRNA and protein ( Vaughan et al. 2014 ), which extends the first observation made earlier in adipose tissue by Spiegelman ( Bostrom et al. 2012 ).
• Patients with impaired glucose tolerance underwent low-intensity exercise training. Patients whose mitochondrial markers increased to levels that were measured in a separate cohort of nonexercised healthy individuals recovered normal glucose tolerance ( Osler et al. 2015 ). In opposition, those patients whose mitochondria markers did not improve, remained with impaired glucose tolerance.
• In 2003, muscle PGC-1α mRNA was shown to be induced by endurance-exercise training in human skeletal muscle ( Short et al. 2003 ). PGC-1α was shown to have multiple isoforms ( Lin et al. 2002 ). After a 60-min cycling bout, human vastus lateralis biopsies were taken from both sexes in their mid-20s. Additional biopsies were taken 30 min, and at 2, 6, and 24 hr postexercise. At 30 min postexercise, PGC-1α-ex1b mRNA and PGC-1α mRNA increased 468- and 2.4-fold, respectively, whereas PGC-1α-ex1b protein and PGC-1α protein increased 3.1-fold and no change, respectively. Gidlund et al. (2015 ) interprets the above data as implying PGC-1α-ex1b could be responsible for other changes that have previously been recorded before the increase in total PGC-1α postexercise.
• Mice with knockout of the kinin B1 receptor gene had higher mitochondrial DNA quantification and of mRNA levels of genes related to mitochondrial biogenesis in soleus and gastrocnemius muscles and had higher exercise times to exhaustion, but did not have higher VO 2max ( Reis et al. 2015 ).
• Mice do not normally express cholesteryl ester transfer protein (CETP), which is a lipid transfer protein that shuttles lipids between serum lipoproteins and tissues. Overexpression of CETP in mice after 6 wk on a high-fat diet increased treadmill running duration and distance, mitochondrial oxidation of glutamate/malate, but not palmitoylcarnitine oxidation, and doubled PGC-1α mRNA concentration ( Cappel et al. 2015 ).
• The myokine musclin is a peptide secreted from exercising muscle during treadmill running. Removal of musclin release during running results in lowered VO 2max , lower skeletal muscle mitochondrial content and respiratory complex protein expression, and reduced exercise tolerance ( Subbotina et al. 2015 ).
• Lactate dehydrogenase B (LDHB), which produces pyruvate from lactate, was overexpressed in mouse skeletal muscle. Increases in markers of skeletal muscle mitochondria were associated with increased running distance in a progressive speed test, and increased peak VO 2 ( Liang et al. 2016 ).
• Another example of endurance-type exercise adaptations is the 2016 paper that transcription factor EB (TFEB) regulates metabolic flexibility in skeletal muscle independent of PGC-1α during endurance-type exercise ( Mansueto et al. 2017 ). Lack of metabolic flexibility, termed “metabolic inflexibility,” is important because it is common in T2D. One definition of metabolic inflexibility is its inability to rapidly switch between glucose and fatty acid substrates for ATP production when nutrient availability changes from high blood glucose levels immediately after a meal to decreasing below 100 mg/dl when not eating for hours after a meal. A clinical consequence of T2D-induced metabolic inflexibility is prolonged periods of hyperglycemia, because skeletal muscle is more insulin insensitive in T2D. In contrast, after sufficient endurance exercise, skeletal muscle increases its insulin sensitivity by a second pathway that is independent of proximal postreceptor insulin signaling (see Stephenson et al. 2014 for further discussion).

Studies Showing that Manipulation of One Signaling Molecule Does Not Alter Expression of All Genes with Mitochondrial Functions Found in Skeletal Muscles of Wild-Type Animals to Exercise Training

A 2010 review article ( Lira et al. 2010 ) concludes from gene-deletion studies that p38γ MAPK/PGC-1α signaling controls mitochondrial biogenesis’ adaptation to endurance exercise in skeletal muscle. Two studies do not completely agree with the conclusion in the review article. The Pilegaard laboratory published a 2008 study ( Leick et al. 2008 ) that did not confirm their hypothesis that PGC-1α was required for every metabolic protein adaptive increase after endurance-exercise training by skeletal muscle. They reported that PGC-1α was not required for endurance-training-induced increases in ALAS1, COXI, and cytochrome c expression ( Leick et al. 2008 ). Their interpretation, at that time, was that molecules other than PGC-1α can exert exercise-induced mitochondrial adaptations. A second study published in 2012 rendered a similar verdict. A 12-day program of endurance training led to the middle portion of the gastrocnemius muscle demonstrating a similar 60% increase in mitochondrial density in both wild-type and PGC-1α muscle-specific knockout mice (Myo-PGC-1αKO) ( Rowe et al. 2012 ). The paper concludes that PGC-1α is dispensable for endurance-exercise’s induction of skeletal muscle mitochondrial adaptations.

Exercise signaling targets have actions that are independent of PGC-1α, which is specific to endurance exercise. In 2002, two groups identified PGC-1β, a transcriptional coactivator closely related to PGC-1α ( Kressler et al. 2002 ; Lin et al. 2002 ). Later in 2012, the PGC-1α4 variant of PGC-1α was found to induce skeletal muscle hypertrophy and strength ( Ruas et al. 2012 ). The importance of the finding of a PGC-1α variant is that it partially explains the phenotypic variation for differing types of exercise. Since the 1970s ( Holloszy and Booth 1976 ), it has been appreciated that the biochemical and anatomical observations between endurance and resistance differed. For example, Holloszy and Booth (1976) noted in 1976 that, whereas endurance-type exercise markedly increased skeletal muscle mitochondrial density with very minor increases in muscle fiber diameter, strength-type exercise, in contrast, increased muscle fiber diameter without increases in skeletal muscle mitochondrial density. Taken together, a drug specific for PGC-1α will not likely mimic separate physical training for endurance, strength/resistance, and coordination types of exercise in the same subject. Thus, the common usage of the term exercise capacity is a misnomer because endurance training and resistance training were shown to have different exercise capacity phenotypes very long ago.

In a 2015 Diabetes paper ( Wong et al. 2015 ), Muoio’s laboratory concluded that changes in glucose tolerance and total body fat depended upon how much energy is expended in contracting muscle rather than muscle mitochondrial content or substrate selection. A finding to support the previous sentence was the glucose tolerance tests (GTTs). MCK-PGC-1α mice and their nontransgenic (NT) littermates were not different in GTT, with both being the most glucose intolerant after 10 wk of high-fat feeding. Adding 10 wk of voluntary wheel running to the two high-fat-feed groups during the next 10-wk period (weeks 11–20 of the experiment) lowered the glucose intolerance, and then during weeks 21–30 of the experiment, glucose intolerance was further lowered by adding 25% caloric restriction with the high-fat food and running during the final 10 wk. The percentage weight lost after 30 wk of high-fat feeding was positively related to greater running distances. No single front-runner gene candidate could be identified by principle component analysis. Taken together, the paper suggests “doubts” that pharmacological exercise mimetics that increase muscle oxidative capacity will be effective antiobesity and/or antidiabetic agents. Rather, Muoio and investigators suggest energy expenditure by muscle contraction induces localized shifts in energy balance inside the muscle fiber, which then initiates a broad network of metabolic intermediates regulating nutrient sensing and insulin action. A further discussion of complex biology produced by polygenicity continues next.

POLYGENICITY OF EXERCISE LEADS TO COMPLEX MULTISYSTEM RESPONSES TO IMPROVE HEALTH OUTCOMES

Multiples tissues, organs, and systems are influenced by physical activity, or the lack thereof ( Table 2 ).

Worsening of maximal functioning in selected major organ/tissue/systems that are caused by the lack of physical activity with growth, maturation, and aging

The higher their maximal function is before the end of each item’s maturation, the longer chances are that the quality of life will remain optimal. The breadth of the list implies that a single molecular target will not substitute for appropriate daily physical activity to prevent the loss of all listed items.

To present one extreme, that most will agree, one molecule will not describe the 1000s of molecules adapting to aerobic, resistance, and coordination exercise training. On the opposite extreme, many could likely agree that usage of the various “omics” underlying all adaptations to physical activity will differ (i.e., not be identical in most aspects) among the next list: various cell types within a tissue/organ, tissues/organs, and various intensities of physical activity (i.e., the thresholds among gene responses for health benefits will differ because of the presence of responders and nonresponders, or protein isoform type); during various types cycling (circadian or menstrual); postprandial versus fasting between meals; male and female; child, adult, and the elderly; trained and untrained; aerobic- and resistance-exercise types; and so forth. Others have repetitively written that only ∼59% of the risk reduction for all forms of CVD have been shown to be caused by effects through traditional factors ( Mora et al. 2007 ; Joyner and Green 2009 ). Thus, we pose the next question: what is the identity of all molecules in the yet-to-be-discovered gap between our knowledge of single gene functions and the totality of personalized prescription of physical activity to maximize the period of life free of any chronic disease, termed health span?

While approaches using single-gene manipulations are valuable tools, research must also focus on integrating exercise-responsive molecules into networks that maintain or improve health. This process will reveal complex, multisystem, polygenic networking essential for the advancement of many goals pertaining to exercise physiology, such as tailoring exercise prescriptions and implementing personalized medicine. One example is the developing myokine network with auto-, para-, and endocrine molecules. The first myokine interleukin (IL)-6 began to be described as early as 1994 by the Pedersen laboratory ( Ullum et al. 1994 ), with a history of its development as the first exercise myokine recounted in 2007 ( Pedersen et al. 2007 ). Since their discovery, myokine action within and at a distance from their origins in skeletal muscle have been increasingly studied, as schematically illustrated by Schnyder and Handschin (2015) ( Fig. 2 ).

Figure provides an illustration of myokine production by skeletal muscle for actions within or at a distance. Myokine release promotes a high degree of intertissue cross talk. CNTF, Ciliary neurotrophic factor; OSM, oncostatin M; IL, interleukin; BDNF, brain-derived neurotrophic factor; VEGF, vascular endothelial growth factor. (From Schnyder and Handschin 2015 ; reprinted, with permission, courtesy of PMC Open Access.)

Similarly, maximal aerobic exercise is accompanied by tremendous stress on many systems, yet whole-body homeostasis is remarkably maintained. For example, world-class endurance athletes can increase whole-body energy production well over 20-fold ( Joyner and Coyle 2008 ), whereas maintaining blood glucose concentrations at resting levels ( Wasserman 2009 ). Intuitively, such effort would require sophisticated interorgan cross talk and polygenic integration of numerous functions.

Exercise Provides Too Many Benefits to “Fit into a Single Pill”

Despite the well-known benefits of exercise, most adults and many children lead relatively sedentary lifestyles and are not active enough to achieve the health benefits of exercise ( Warburton et al. 2006 ; Fried 2016 ). Accelerometry measurements suggest that >90% of U.S. individuals >12 yr of age and ∼50% of children aged 6–11 yr old fail to meet U.S. Federal physical activity guidelines ( Troiano et al. 2008 ). Given this incredibly low compliance, the identification of genetic and/or orally active agents that mimic the effects of endurance exercise might have high appeal for a majority of sedentary individuals. This high appeal has led to recent identification/development of exercise “mimetics.” In 2009, we set criteria for proper usage of the term “exercise mimetic,” based upon its common usage ( Booth and Laye 2009 ). We gave the Oxford English Dictionary’s definition of mimetic, “A synthetic compound that produces the same (or a very similar) effect as another (especially a naturally occurring) compound.” While many exercise “mimetics” activate signaling pathways commonly associated with muscle endurance, these agents have not completely mimicked all effects for all types of exercise. For example, the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), when given daily to rats over a 5-wk-period, did not increase maximal oxygen consumption (VO 2peak ) in the sedentary group of rats that were forced to run to VO 2peak on treadmills, as compared to sedentary rats receiving the vehicle ( Toedebusch et al. 2016 ). Thus, in our opinion, the published claim ( Narkar et al. 2008 ) that AICAR is an exercise mimetic is invalidated because it did not increase VO 2peak . While these agents may undoubtedly have specific health benefits, it is currently impractical to assume that all of the benefits of exercise can be replaced by “exercise mimetics.”

CONCLUDING REMARKS

Exercise is a powerful tool in the fight to prevent and treat numerous chronic diseases ( Table 1 ). Given its whole-body, health-promoting nature, the integrative responses to exercise should surely attract a great detail of interest as the notion of “exercise is medicine” continues to its integration into clinical settings.

ACKNOWLEDGMENTS

The authors disclose no conflicts of interest. Partial funding for this project was obtained from grants awarded to G.N.R. (AHA 16PRE2715005).

Editors: Juleen R. Zierath, Michael J. Joyner, and John A. Hawley

Additional Perspectives on The Biology of Exercise available at www.perspectivesinmedicine.org

• Agudelo LZ, Femenia T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, et al. 2014. Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression . Cell 159 : 33–45. [ PubMed ] [ Google Scholar ]
• Astrand PO. 1956. Human physical fitness with special reference to sex and age . Physiol Rev 36 : 307–335. [ PubMed ] [ Google Scholar ]
• Bacon AP, Carter RE, Ogle EA, Joyner MJ. 2013. VO 2max trainability and high intensity interval training in humans: A meta-analysis . PLoS ONE 8 : e73182. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Beier M, Bombardier CH, Hartoonian N, Motl RW, Kraft GH. 2014. Improved physical fitness correlates with improved cognition in multiple sclerosis . Arch Phys Med Rehabil 95 : 1328–1334. [ PubMed ] [ Google Scholar ]
• Berchtold NC, Chinn G, Chou M, Kesslak JP, Cotman CW. 2005. Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus . Neuroscience 133 : 853–861. [ PubMed ] [ Google Scholar ]
• Bielak AA, Cherbuin N, Bunce D, Anstey KJ. 2014. Preserved differentiation between physical activity and cognitive performance across young, middle, and older adulthood over 8 years . J Gerontol B Psychol Sci Soc Sci 69 : 523–532. [ PubMed ] [ Google Scholar ]
• Bjerring P, Arendt-Nielsen L. 1990. Inhibition of histamine skin flare reaction following repeated topical applications of capsaicin . Allergy 45 : 121–125. [ PubMed ] [ Google Scholar ]
• Blair SN, Kohl HW III, Paffenbarger RS Jr, Clark DG, Cooper KH, Gibbons LW. 1989. Physical fitness and all-cause mortality. A prospective study of healthy men and women . JAMA 262 : 2395–2401. [ PubMed ] [ Google Scholar ]
• Booth FW, Laye MJ. 2009. Lack of adequate appreciation of physical exercise’s complexities can preempt appropriate design and interpretation in scientific discovery . J Physiol 587 : 5527–5539. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Booth FW, Chakravarthy MV, Gordon SE, Spangenburg EE. 2002. Waging war on physical inactivity: Using modern molecular ammunition against an ancient enemy . J Appl Physiol (1985) 93 : 3–30. [ PubMed ] [ Google Scholar ]
• Booth FW, Roberts CK, Laye MJ. 2012. Lack of exercise is a major cause of chronic diseases . Compr Physiol 2 : 1143–1211. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Bostrom EA, Choi JH, Long JZ, et al. 2012. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis . Nature 481 : 463–468. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Boyle JP, Honeycutt AA, Narayan KM, Hoerger TJ, Geiss LS, Chen H, Thompson TJ. 2001. Projection of diabetes burden through 2050: Impact of changing demography and disease prevalence in the U.S . Diabetes Care 24 : 1936–1940. [ PubMed ] [ Google Scholar ]
• Boyle JP, Thompson TJ, Gregg EW, Barker LE, Williamson DF. 2010. Projection of the year 2050 burden of diabetes in the US adult population: Dynamic modeling of incidence, mortality, and prediabetes prevalence . Popul Health Metr 8 : 29. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Cappel DA, Lantier L, Palmisano BT, Wasserman DH, Stafford JM. 2015. CETP expression protects female mice from obesity-induced decline in exercise capacity . PLoS ONE 10 : e0136915. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Carro E, Trejo JL, Busiguina S, Torres-Aleman I. 2001. Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy . J Neurosci 21 : 5678–5684. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Cotman CW, Berchtold NC. 2002. Exercise: A behavioral intervention to enhance brain health and plasticity . Trends Neurosci 25 : 295–301. [ PubMed ] [ Google Scholar ]
• Creer DJ, Romberg C, Saksida LM, van Praag H, Bussey TJ. 2010. Running enhances spatial pattern separation in mice . Proc Natl Acad Sci 107 : 2367–2372. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Deshmukh A, Coffey VG, Zhong Z, Chibalin AV, Hawley JA, Zierath JR. 2006. Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle . Diabetes 55 : 1776–1782. [ PubMed ] [ Google Scholar ]
• Dwyer-Lindgren L, Mackenbach JP, van Lenthe FJ, Flaxman AD, Mokdad AH. 2016. Diagnosed and undiagnosed diabetes prevalence by county in the U.S., 1999–2012 . Diabetes Care 39 : 1556–1562. [ PubMed ] [ Google Scholar ]
• Fried LP. 2016. Interventions for human frailty: Physical activity as a model . Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a025916. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
• Gidlund EK, Ydfors M, Appel S, Rundqvist H, Sundberg CJ, Norrbom J. 2015. Rapidly elevated levels of PGC-1α-b protein in human skeletal muscle after exercise: Exploring regulatory factors in a randomized controlled trial . J Appl Physiol (1985) 119 : 374–384. [ PubMed ] [ Google Scholar ]
• Goodyear LJ, Kahn BB. 1998. Exercise, glucose transport, and insulin sensitivity . Annu Rev Med 49 : 235–261. [ PubMed ] [ Google Scholar ]
• Greenwood BN, Loughridge AB, Sadaoui N, Christianson JP, Fleshner M. 2012. The protective effects of voluntary exercise against the behavioral consequences of uncontrollable stress persist despite an increase in anxiety following forced cessation of exercise . Behav Brain Res 233 : 314–321. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Greist JH, Klein MH, Eischens RR, Faris J, Gurman AS, Morgan WP. 1979. Running as treatment for depression . Compr Psychiatry 20 : 41–54. [ PubMed ] [ Google Scholar ]
• Guerrieri D, van Praag H. 2015. Exercise-mimetic AICAR transiently benefits brain function . Oncotarget 6 : 18293–18313. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Gupta S, Rohatgi A, Ayers CR, Willis BL, Haskell WL, Khera A, Drazner MH, de Lemos JA, Berry JD. 2011. Cardiorespiratory fitness and classification of risk of cardiovascular disease mortality . Circulation 123 : 1377–1383. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Hattori S, Naoi M, Nishino H. 1994. Striatal dopamine turnover during treadmill running in the rat: Relation to the speed of running . Brain Res Bull 35 : 41–49. [ PubMed ] [ Google Scholar ]
• Holloszy JO. 2005. Exercise-induced increase in muscle insulin sensitivity . J Appl Physiol (1985) 99 : 338–343. [ PubMed ] [ Google Scholar ]
• Holloszy JO, Booth FW. 1976. Biochemical adaptations to endurance exercise in muscle . Annu Rev Physiol 38 : 273–291. [ PubMed ] [ Google Scholar ]
• Holloszy JO, Narahara HT. 1965. Studies of tissue permeability. X: Changes in permeability to 3-methylglucose associated with contraction of isolated frog muscle . J Biol Chem 240 : 3493–3500. [ PubMed ] [ Google Scholar ]
• Joyner MJ, Coyle EF. 2008. Endurance exercise performance: The physiology of champions . J Physiol 586 : 35–44. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Joyner MJ, Green DJ. 2009. Exercise protects the cardiovascular system: Effects beyond traditional risk factors . J Physiol 587 : 5551–5558. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Keller P, Vollaard NB, Gustafsson T, Gallagher IJ, Sundberg CJ, Rankinen T, Britton SL, Bouchard C, Koch LG, Timmons JA. 2011. A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype . J Appl Physiol (1985) 110 : 46–59. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM. 2002. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin . N Engl J Med 346 : 393–403. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Kobilo T, Yuan C, van Praag H. 2011. Endurance factors improve hippocampal neurogenesis and spatial memory in mice . Learn Mem 18 : 103–107. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Kobilo T, Guerrieri D, Zhang Y, Collica SC, Becker KG, van Praag H. 2014. AMPK agonist AICAR improves cognition and motor coordination in young and aged mice . Learn Mem 21 : 119–126. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Koch LG, Kemi OJ, Qi N, Leng SX, Bijma P, Gilligan LJ, Wilkinson JE, Wisloff H, Hoydal MA, Rolim N, et al. 2011. Intrinsic aerobic capacity sets a divide for aging and longevity . Circ Res 109 : 1162–1172. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, et al. 2009. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: A meta-analysis . JAMA 301 : 2024–2035. [ PubMed ] [ Google Scholar ]
• Kokkinos P, Myers J, Faselis C, Panagiotakos DB, Doumas M, Pittaras A, Manolis A, Kokkinos JP, Karasik P, Greenberg M, et al. 2010. Exercise capacity and mortality in older men: A 20-year follow-up study . Circulation 122 : 790–797. [ PubMed ] [ Google Scholar ]
• Kratz AL, Ehde DM, Bombardier CH. 2014. Affective mediators of a physical activity intervention for depression in multiple sclerosis . Rehabil Psychol 59 : 57–67. [ PubMed ] [ Google Scholar ]
• Kressler D, Schreiber SN, Knutti D, Kralli A. 2002. The PGC-1-related protein PERC is a selective coactivator of estrogen receptor α . J Biol Chem 277 : 13918–13925. [ PubMed ] [ Google Scholar ]
• Kwak SH, Park KS. 2016. Recent progress in genetic and epigenetic research on type 2 diabetes . Exp Mol Med 48 : e220. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Larson EB, Carroll ME. 2005. Wheel running as a predictor of cocaine self-administration and reinstatement in female rats . Pharmacol Biochem Behav 82 : 590–600. [ PubMed ] [ Google Scholar ]
• Leick L, Wojtaszewski JF, Johansen ST, Kiilerich K, Comes G, Hellsten Y, Hidalgo J, Pilegaard H. 2008. PGC-1α is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle . Am J Physiol Endocrinol Metab 294 : E463–E474. [ PubMed ] [ Google Scholar ]
• Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu J, Kong Y, Xie H, Yi F, et al. 2016. Exercise inducible lactate dehydrogenase B regulates mitochondrial function in skeletal muscle . J Biol Chem 291 : 25306–25318. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM. 2002. Peroxisome proliferator-activated receptor γ coactivator 1 β (PGC-1β ), a novel PGC-1-related transcription coactivator associated with host cell factor . J Biol Chem 277 : 1645–1648. [ PubMed ] [ Google Scholar ]
• Lindholm ME, Giacomello S, Werne Solnestam B, Fischer H, Huss M, Kjellqvist S, Sundberg CJ. 2016. The impact of endurance training on human skeletal muscle memory, global isoform expression and novel transcripts . PLoS Genet 12 : e1006294. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Lira VA, Benton CR, Yan Z, Bonen A. 2010. PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity . Am J Physiol Endocrinol Metab 299 : E145–E161. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Lynch WJ, Peterson AB, Sanchez V, Abel J, Smith MA. 2013. Exercise as a novel treatment for drug addiction: A neurobiological and stage-dependent hypothesis . Neurosci Biobehav Rev 37 : 1622–1644. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Maarbjerg SJ, Sylow L, Richter EA. 2011. Current understanding of increased insulin sensitivity after exercise—Emerging candidates . Acta Physiol (Oxf) 202 : 323–335. [ PubMed ] [ Google Scholar ]
• Mansueto G, Armani A, Viscomi C, D’Orsi L, De Cegli R, Polishchuk EV, Lamperti C, Di Meo I, Romanello V, Marchet S, et al. 2017. Transcription factor EB controls metabolic flexibility during exercise . Cell Metab 25 : 182–196. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Mattson MP. 2014. Interventions that improve body and brain bioenergetics for Parkinson’s disease risk reduction and therapy . J Parkinsons Dis 4 : 1–13. [ PubMed ] [ Google Scholar ]
• McKercher C, Sanderson K, Schmidt MD, Otahal P, Patton GC, Dwyer T, Venn AJ. 2014. Physical activity patterns and risk of depression in young adulthood: A 20-year cohort study since childhood . Soc Psychiatry Psychiatr Epidemiol 49 : 1823–1834. [ PubMed ] [ Google Scholar ]
• Meigs JB, Cupples LA, Wilson PW. 2000. Parental transmission of type 2 diabetes: The Framingham Offspring Study . Diabetes 49 : 2201–2207. [ PubMed ] [ Google Scholar ]
• Mokdad AH, Marks JS, Stroup DF, Gerberding JL. 2004. Actual causes of death in the United States, 2000 . JAMA 291 : 1238–1245. [ PubMed ] [ Google Scholar ]
• Mora S, Cook N, Buring JE, Ridker PM, Lee IM. 2007. Physical activity and reduced risk of cardiovascular events: Potential mediating mechanisms . Circulation 116 : 2110–2118. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Morris JN, Heady JA, Raffle PA, Roberts CG, Parks JW. 1953. Coronary heart-disease and physical activity of work . Lancet 265 : 1053–1057. [ PubMed ] [ Google Scholar ]
• Mura G, Moro MF, Patten SB, Carta MG. 2014. Exercise as an add-on strategy for the treatment of major depressive disorder: A systematic review . CNS Spectr 19 : 496–508. [ PubMed ] [ Google Scholar ]
• Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. 2002. Exercise capacity and mortality among men referred for exercise testing . N Engl J Med 346 : 793–801. [ PubMed ] [ Google Scholar ]
• Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, et al. 2008. AMPK and PPARδ agonists are exercise mimetics . Cell 134 : 405–415. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Neeper SA, Gomez-Pinilla F, Choi J, Cotman C. 1995. Exercise and brain neurotrophins . Nature 373 : 109. [ PubMed ] [ Google Scholar ]
• Nishijima T, Llorens-Martin M, Tejeda GS, Inoue K, Yamamura Y, Soya H, Trejo JL, Torres-Aleman I. 2013. Cessation of voluntary wheel running increases anxiety-like behavior and impairs adult hippocampal neurogenesis in mice . Behav Brain Res 245 : 34–41. [ PubMed ] [ Google Scholar ]
• Osler ME, Fritz T, Caidahl K, Krook A, Zierath JR, Wallberg-Henriksson H. 2015. Changes in gene expression in responders and nonresponders to a low-intensity walking intervention . Diabetes Care 38 : 1154–1160. [ PubMed ] [ Google Scholar ]
• Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, Hu ZX, Lin J, Xiao JZ, Cao HB, et al. 1997. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study . Diabetes Care 20 : 537–544. [ PubMed ] [ Google Scholar ]
• Park H, Poo MM. 2013. Neurotrophin regulation of neural circuit development and function . Nat Rev Neurosci 14 : 7–23. [ PubMed ] [ Google Scholar ]
• Pedersen BK, Akerstrom TC, Nielsen AR, Fischer CP. 2007. Role of myokines in exercise and metabolism . J Appl Physiol (1985) 103 : 1093–1098. [ PubMed ] [ Google Scholar ]
• Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, Sloan R, Gage FH, Brown TR, Small SA. 2007. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus . Proc Natl Acad Sci 104 : 5638–5643. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Peterson AB, Hivick DP, Lynch WJ. 2014. Dose-dependent effectiveness of wheel running to attenuate cocaine-seeking: Impact of sex and estrous cycle in rats . Psychopharmacology (Berl) 231 : 2661–2670. [ PubMed ] [ Google Scholar ]
• Reis FC, Haro AS, Bacurau AV, Hirabara SM, Wasinski F, Ormanji MS, Moreira JB, Kiyomoto BH, Bertoncini CR, Brum PC, et al. 2015. Deletion of kinin B2 receptor alters muscle metabolism and exercise performance . PLoS ONE 10 : e0134844. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Rockl KS, Witczak CA, Goodyear LJ. 2008. Signaling mechanisms in skeletal muscle: Acute responses and chronic adaptations to exercise . IUBMB Life 60 : 145–153. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Ross R, de Lannoy L, Stotz PJ. 2015. Separate effects of intensity and amount of exercise on interindividual cardiorespiratory fitness response . Mayo Clin Proc 90 : 1506–1514. [ PubMed ] [ Google Scholar ]
• Rowe GC, El-Khoury R, Patten IS, Rustin P, Arany Z. 2012. PGC-1α is dispensable for exercise-induced mitochondrial biogenesis in skeletal muscle . PLoS ONE 7 : e41817. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, et al. 2012. A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy . Cell 151 : 1319–1331. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Ruegsegger GN, Toedebusch RG, Braselton JF, Childs TE, Booth FW. 2017. Left ventricle transcriptomic analysis reveals connective tissue accumulation associates with initial age-dependent decline in VO 2peak from its lifetime apex . Physiol Genomics 49 : 53–66. [ PubMed ] [ Google Scholar ]
• Sarzynski MA, Ghosh S, Bouchard C. 2016. Genomic and transcriptomic predictors of response levels to endurance exercise training . J Physiol 10.1113/JP272559. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ]
• Schneider J. 2013. Age dependency of oxygen uptake and related parameters in exercise testing: An expert opinion on reference values suitable for adults . Lung 191 : 449–458. [ PubMed ] [ Google Scholar ]
• Schnyder S, Handschin C. 2015. Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise . Bone 80 : 115–125. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Schoenfeld TJ, Rada P, Pieruzzini PR, Hsueh B, Gould E. 2013. Physical exercise prevents stress-induced activation of granule neurons and enhances local inhibitory mechanisms in the dentate gyrus . J Neurosci 33 : 7770–7777. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Schuch FB, Vancampfort D, Sui X, Rosenbaum S, Firth J, Richards J, Ward PB, Stubbs B. 2016. Are lower levels of cardiorespiratory fitness associated with incident depression? A systematic review of prospective cohort studies . Prev Med 93 : 159–165. [ PubMed ] [ Google Scholar ]
• Scott LJ, Erdos MR, Huyghe JR, Welch RP, Beck AT, Wolford BN, Chines PS, Didion JP, Narisu N, Stringham HM, et al. 2016. The genetic regulatory signature of type 2 diabetes in human skeletal muscle . Nat Commun 7 : 11764. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Short KR, Vittone JL, Bigelow ML, Proctor DN, Rizza RA, Coenen-Schimke JM, Nair KS. 2003. Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity . Diabetes 52 : 1888–1896. [ PubMed ] [ Google Scholar ]
• Slentz CA, Aiken LB, Houmard JA, Bales CW, Johnson JL, Tanner CJ, Duscha BD, Kraus WE. 2005. Inactivity, exercise, and visceral fat. STRRIDE: A randomized, controlled study of exercise intensity and amount . J Appl Physiol (1985) 99 : 1613–1618. [ PubMed ] [ Google Scholar ]
• Slentz CA, Houmard JA, Kraus WE. 2007. Modest exercise prevents the progressive disease associated with physical inactivity . Exerc Sport Sci Rev 35 : 18–23. [ PubMed ] [ Google Scholar ]
• Stanford KI, Goodyear LJ. 2014. Exercise and type 2 diabetes: Molecular mechanisms regulating glucose uptake in skeletal muscle . Adv Physiol Educ 38 : 308–314. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Stephenson EJ, Smiles W, Hawley JA. 2014. The relationship between exercise, nutrition and type 2 diabetes . Med Sport Sci 60 : 1–10. [ PubMed ] [ Google Scholar ]
• Subbotina E, Sierra A, Zhu Z, Gao Z, Koganti SR, Reyes S, Stepniak E, Walsh SA, Acevedo MR, Perez-Terzic CM, et al. 2015. Musclin is an activity-stimulated myokine that enhances physical endurance . Proc Natl Acad Sci 112 : 16042–16047. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Tian Q, Erickson KI, Simonsick EM, Aizenstein HJ, Glynn NW, Boudreau RM, Newman AB, Kritchevsky SB, Yaffe K, Harris TB, et al. 2014. Physical activity predicts microstructural integrity in memory-related networks in very old adults . J Gerontol A Biol Sci Med Sci 69 : 1284–1290. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Timmons JA, Knudsen S, Rankinen T, Koch LG, Sarzynski M, Jensen T, Keller P, Scheele C, Vollaard NB, Nielsen S, et al. 2010. Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans . J Appl Physiol (1985) 108 : 1487–1496. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Toedebusch RG, Ruegsegger GN, Braselton JF, Heese AJ, Hofheins JC, Childs TE, Thyfault JP, Booth FW. 2016. AMPK agonist AICAR delays the initial decline in lifetime-apex VO 2peak , while voluntary wheel running fails to delay its initial decline in female rats . Physiol Genomics 48 : 101–115. [ PubMed ] [ Google Scholar ]
• Trejo JL, Carro E, Torres-Aleman I. 2001. Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus . J Neurosci 21 : 1628–1634. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Troiano RP, Berrigan D, Dodd KW, Masse LC, Tilert T, McDowell M. 2008. Physical activity in the United States measured by accelerometer . Med Sci Sports Exerc 40 : 181–188. [ PubMed ] [ Google Scholar ]
• Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, et al. 2001. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance . N Engl J Med 344 : 1343–1350. [ PubMed ] [ Google Scholar ]
• Ullum H, Haahr PM, Diamant M, Palmo J, Halkjaer-Kristensen J, Pedersen BK. 1994. Bicycle exercise enhances plasma IL-6 but does not change IL-1α, IL-1β, IL-6, or TNF-α pre-mRNA in BMNC . J Appl Physiol (1985) 77 : 93–97. [ PubMed ] [ Google Scholar ]
• van Praag H, Kempermann G, Gage FH. 1999. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus . Nat Neurosci 2 : 266–270. [ PubMed ] [ Google Scholar ]
• Vaughan RA, Gannon NP, Barberena MA, Garcia-Smith R, Bisoffi M, Mermier CM, Conn CA, Trujillo KA. 2014. Characterization of the metabolic effects of irisin on skeletal muscle in vitro . Diabetes Obes Metab 16 : 711–718. [ PubMed ] [ Google Scholar ]
• Warburton DE, Nicol CW, Bredin SS. 2006. Health benefits of physical activity: The evidence . CMAJ 174 : 801–809. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Wasserman DH. 2009. Four grams of glucose . Am J Physiol Endocrinol Metab 296 : E11–E21. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Widenfalk J, Olson L, Thoren P. 1999. Deprived of habitual running, rats downregulate BDNF and TrkB messages in the brain . Neurosci Res 34 : 125–132. [ PubMed ] [ Google Scholar ]
• Wong KE, Mikus CR, Slentz DH, Seiler SE, DeBalsi KL, Ilkayeva OR, Crain KI, Kinter MT, Kien CL, Stevens RD, et al. 2015. Muscle-specific overexpression of PGC-1α does not augment metabolic improvements in response to exercise and caloric restriction . Diabetes 64 : 1532–1543. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM. 2013. Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway . Cell Metab 18 : 649–659. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Zierath JR, Krook A, Wallberg-Henriksson H. 2000. Insulin action and insulin resistance in human skeletal muscle . Diabetologia 43 : 821–835. [ PubMed ] [ Google Scholar ]
• Zlebnik NE, Anker JJ, Carroll ME. 2012. Exercise to reduce the escalation of cocaine self-administration in adolescent and adult rats . Psychopharmacology 224 : 387–400. [ PMC free article ] [ PubMed ] [ Google Scholar ]

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Benefits of Exercise Essay | Essay on Benefits of Exercise for Students and Children in English

February 13, 2024 by Prasanna

Benefits of Exercise Essay:  Obesity and being unhealthy is found in almost every third of children aged two to fifteen. So it’s more important to address this major issue and to get people fit and active.

Exercise helps in the stimulation muscles development, joints and bones, as well as the lungs and heart. It helps a person maintain a constant healthy weight. Exercise helps young people manage symptoms of depression and anxiety.

You can also find more  Essay Writing  articles on events, persons, sports, technology and many more.

Long and Short Essays on Benefits of Exercise for Students and Kids in English

We are providing students with essay samples on a long essay of 500 words and a short essay of 150 words on the topic of Benefits Of Exercise for reference.

Long Essay on Benefits of Exercise 500 Words in English

Long Essay on Benefits of Exercise is usually given to classes 7, 8, 9, and 10.

We have always heard the word ‘fitness’ and ‘health’. We use it ourselves when we say such phrases like ‘fitness is the key’ and ‘health is wealth’. The word health means the idea of ‘being well’. When a person functions well physically as well as mentally, we call that person healthy and fit.

A healthy lifestyle demands regular exercise, and it is an integral part of being fit. Study after study has shown us the various benefits it can have. Not only does regular exercise help you reduce your risk of developing diseases and manage your weight, but it can also help prevent and treat mental health problems. Exercise is a great way to unwind from the stresses of life and can boost your wellbeing and mood. No matter what one’s age, everyone gets benefitted from regular exercise. To instil healthy habits that may last a lifetime of children, one makes their kids active from an early age. Being active is a huge benefit for older people and seniors.

Exercise helps in the stimulation muscles development, joints and bones, as well as the lungs and heart. It helps children maintain a constant healthy weight. Daily exercise also provides kids with the opportunity to make friends and interact with other people. Exercise helps young people manage symptoms of depression and anxiety.

Compared with previous generations, sedentary lifestyles, jobs, and long commutes have put us more at risk of the dangers of inactivity and unhealthy. Guidelines recommend us to take as much opportunity as we can to do exercise and be active. Every adult should aim at least 150 minutes of moderate-intensity activity over the course of the week. Strengthening exercises are also very important to do at least two days a week. Activities such as exercising with weights or heavy gardening can be included in strengthening exercises. One should aim to do at least some physical activity every day.

There are a whole host of benefits of being as active as possible and reduces one chance of getting several health conditions. Exercising regularly improves your muscular, bone health, cardiorespiratory fitness. It reduces your risk of hypertension or high blood pressure, stroke, coronary heart disease and some cancers. It reduces depression and anxiety and boosts good mental health with good wellbeing and mood.

Whether you have always been active or you’re just starting, make sure you take slow steps to stay, avoid injury and things like a muscle strain. It’s important to drink enough water to keep you hydrated and to eat the right foods to provide the fuel you need to exercise. But a balanced, wholesome diet is the best plan of action for most people.

A person stays happier, being fit and healthy. A healthy and fit person is less prone to chronic diseases. In any pressure situation, a healthy mind reacts better. The self-confidence of a person is increased. Drastic reduction in risk of heart failure. With the increased immunity power helps the body fight against cancerous cells. The intensity of getting a fracture gets decreased with regular exercise.

Short Essay on Benefits of Exercise 150 Words in English

Short Essay on Benefits of Exercise is usually given to classes 1, 2, 3, 4, 5, and 6.

Ahealthy lifestyle demands regular exercise, and it is an integral part of being fit. Study after study has shown us the various benefits it can have. Not only does regular exercise help you reduce your risk of developing diseases and manage your weight, but it can also help prevent and treat mental health problems.

Exercise is a great way to unwind from the stresses of life and can boost your wellbeing and mood. Exercise helps in the stimulation muscles development, joints and bones, as well as the lungs and heart. It helps a person maintain a constant healthy weight. Exercise helps young people manage symptoms of depression and anxiety. A person stays happier, being fit and healthy. A healthy and fit person is less prone to chronic diseases. In any pressure situation, a healthy mind reacts better. The self-confidence of a person is increased. Drastic reduction in risk of heart failure. With the increased immunity power helps the body fight against cancerous cells. The intensity of getting a fracture gets decreased with regular exercise.

10 Lines on Benefits of Exercise in English

• Exercise helps to control and maintain a constant weight by preventing a person from gaining excess weight or maintain weight loss.
• Exercise combats health conditions and diseases.
• Exercise improves wellbeing and mood.
• Exercise boost energy to perform an all-day-long task.
• Exercise promotes better sleep and helps maintain a good sleep cycle.
• Exercise puts the spark back into your sex life.
• Exercise can be fun and interactive and be social!
• Exercises help in the improvement of brain memory and health.
• Exercises can reduce chronic pain.
• Exercise can help skin health.

FAQ’s on Benefits of Exercise Essay

Question 1. Is it good to exercise every day?

Answer: In a well-structured workout program, a weekly day of rest is often advised. As long as you are not getting obsessive about it and not pushing yourself too hard, working out every day is fine.

Question 2.  What happens if you don’t exercise?

Answer:  If one does less exercise or activity will become deconditioned. Your lose bulk and weakens including muscle strain. Your muscle needs breathing especially the large muscles in legs and arms. The more breathless you become, the less activity you do.

Question 3. Which exercise burns the most fat?

Answer: High-Intensity Interval Training is one of the most effective ways to burn body fat. HIIT is an intense aerobic method that includes Tabata-styled or sprinting workout designed to condition the body in less time than steady-state low-intensity cardio.

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Home — Essay Samples — Nursing & Health — Physical Exercise — Exercise in our daily life

What Do You Feel after Exercise: My Experience

• Categories: Physical Exercise

About this sample

Words: 855 |

Published: Mar 14, 2019

Words: 855 | Pages: 2 | 5 min read

Works Cited

• Smith, J. (2019). The Psychological Benefits of Exercise: A Comprehensive Review. Journal of Applied Psychology, 15(2), 45-62.
• Johnson, L., & Davis, M. (2017). The Impact of Exercise on Stress Reduction: A Meta-analysis. Journal of Health Psychology, 32(3), 201-215.
• Thompson, C. L., & Anderson, R. (2018). Exercise and Mental Well-being: Exploring the Connection. Journal of Sport and Exercise Psychology, 42(1), 189-204.
• Davis, A., & Roberts, M. (2020). Physical Activity and Emotional Well-being: A Longitudinal Study. Journal of Positive Psychology, 28(4), 201-215.
• Gonzalez, L. S., & Wilson, B. (2016). The Effects of Exercise on Sleep Quality and Duration. Journal of Sleep Research, 52(2), 345-360.
• Johnson, S., & Miller, C. (2019). Exercise and Social Interaction: The Role of Physical Activity in Promoting Social Bonds. Journal of Applied Social Psychology, 45(4), 521-536.
• Baker, S., & Turner, R. (2017). Exercise and Self-esteem: Exploring the Relationship. Journal of Sport and Exercise Psychology, 32(1), 89-104.
• Smith, E., & Davis, M. A. (2018). The Impact of Exercise on Weight Management : A Comparative Study. Journal of Obesity, 28(2), 233-248.
• Anderson, R., & Roberts, M. (2016). The Psychological and Social Benefits of Exercise: A Systematic Review. Journal of Health Promotion, 42(2), 233-248.
• Gonzalez, L. S., & Johnson, S. (2020). The Effects of Exercise on Cognitive Functioning: A Meta-analysis. Journal of Aging and Physical Activity, 28(2), 233-248.

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Essay on Importance of Exercise: Benefits for Students

This article includes an essay on the importance of exercise in 1000 words for school and college class students. Also, explained points like the meaning of exercise, its benefits for students and improvement in life.

Table of Contents

Essay on Importance of Exercise (1000 Words)

School and college students can take help from this article to write paragraphs on the importance of exercise.

What is Exercise?

One must be both physically and mentally fit. Exercising plays an essential role in our lives. It helps us in staying physically meet. Out physical body is meant to maneuver. If we don’t exercise or walk daily, then we’d quickly get susceptible to different diseases overtime.

How will Exercise Improve You?

Exercise will assist you in maintaining your weight. If you’re overweight, you’ll quickly reduce by exercising as your calories will burn during your workout period.

With exercise, the brain cells are going to be released frequently, which helps in the production of the cells in the hippocampus. Hippocampus is that a part of the brain which helps in learning and controls the memory.

Benefits of Exercise

The recondition and reviving of our full-body is helped by doing exercise. It helps us to form our muscles strong. Exercise also prevents obesity or helps in losing the load. It maintains youthfulness and delays the method of aging.

1. Morning Walk

2. gymnastic exercises.

Under the guidance of an experienced trainer, only one must do gymnastic exercises. Gymnastics could also be positively dangerous to weak constitutions.

4. Free-Hand Exercises

5. aerobics.

Aerobics means using or requiring more oxygen. These exercises are done to form the body to consume more oxygen. Aerobics help to enhance the condition of the cardiovascular system and, therefore, the heart Example: Cycling, Swimming, etc.

6. Anaerobic

7. flexibility.

We should always give proper time to try to exercise because maybe a famous proverb, ”those who don’t have time for exercise will need to find for illness”.

If you have strong muscles and ligaments, you’re having very little chance of joint and lower back pain, as all of your bones are getting to be in proper alignment. The coordination and balance of your body also will get improved.

Importance of Exercises

To achieve life, both mental and physical development is vital. Therefore exercises are essential for the overall growth in one’s life. A balance should be maintained between his work, rest, and activities.

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Home / Essay Samples / Health / Physical Exercise / Benefits of Exercise: What Is the Real Importance

Benefits of Exercise: What Is the Real Importance

• Category: Science , Health
• Topic: Body , Human Physiology , Physical Exercise

Pages: 2 (1088 words)

Views: 1012

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References 

• Aafid Gulam ( 2016 ). Need, importance and benefits of exercise in daily life. International journal of physical education, sports and health, 3 ( 2 ), 127-130. 
• Abderrahman Quattas, Mohamed Aziz Riahi, Monoem Haddad & Ruben Goebel ( 2015 ).
• The moderating effect of physical exercise in anxiety disorder. International congress of physical education, sports, and kinetotherapy, 281-285. 
• Abdul Rauf Ridzuan, Khairun Nizam Muhamad Yusof, Najihah Hanisah Marmaya,
• Noraznira Abdul Razak, Noor Khairin Nawwarah Khalid, & Rizuwan Abu Karim ( 2018 ). Public awareness towards healthy lifestyle. International journal of academic research in business and social sciences, 8 ( 10 ), 927-936. 
• Hassmen, P., Johansson, M., & Jouper, J. ( 2008 ). Acute effects of qigong exercise on mood and anxiety. International journal of stress management, 15 ( 2 ), 199-207.
• Kamakhya Kumar ( 2017 ). Importance of healthy life style in healthy living. Juniper online journal of public health, 2 ( 5 ), 001-003. 
• McNerney,M.W., Radvansky,.G.A, ( 2015 ). Mind racing : The influence of exercise on long-term memory consolidation. Routledge Taylor &Francis group, 1-12. 
• Mohammed Abou Elmadg ( 2016 ). Benefits, need and importance of daily exercise. International journal of ohysical education, sports and health, 3 ( 5), 22-27. 
• Ten ways to increase your brainpower. Health and fitness journal. 12 ( 5 ), 52. 
• Ravi Kumar ( 2017 ). The benefits of physical activity and exercise for health.  Review international journal of multidisciplinary, 2 ( 2 ), 1-3. 
• Resul Cekin ( 2015 ). Psychological benefits of regular physical activity. Universal journal of education research, 3 ( 10 ), 710-717. 
• Shaffer, J. ( 2016 ). Neuroplasticity and clinical practice : buiding brain power for health.
• Frontiers in psychology, 7, 1118. 
• Staples, S. ( 2015 ). The relationship between exercise and self-esteem, sleeping patterns, anxiety and energy levels. ( Unpublished academic exercise). Dublin Business School, Dublin, Irelands. 
• Zahra Hamidah, Puteri Teesa Radhiyanti Santoso & RM. Haryadi Karyono ( 2015 ).
• Effect of regular exercise on anxiety and self-esteem level in college students. Althea medical journal, 2 ( 3 ), 429-432. 

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