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PhD and Masters Research Degrees In Australia

Are you looking to further your knowledge and become an expert in your field of interest? Start your greatest adventure with a Higher Degree by Research at the University of Adelaide.

Ranked in the top 100 of universities globally, at the University of Adelaide you will be involved in discovery, innovation and cutting-edge research. Enjoy an outstanding research environment under the wing of top-ranked researchers and establish life-long connections with industry and like-minded students. Start building your future now.

Find your degree

There is an option for every discipline. Explore our Masters and Doctorate degrees by research.

Industry opportunities

Industry opportunities

Turn theory into practice with a research internship and industry-engaged higher degree research program (HDR). Develop expertise in your chosen field and extend your professional contacts and networks.

Programs are open to applicants who are eligible for onshore study and meet the University of Adelaide’s English Language Requirements at the time of the application.

International joint PhDs

International joint PhDs

Widen your research connections and study at two high quality universities within Australia or between different countries.

You will spend time at each university and receive a single doctoral degree jointly awarded by both institutions.

Research connections

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Australian Institute for Machine Learning

The University of Adelaide’s Australian Institute for Machine Learning is the largest university-based research group in machine learning in Australia. Research areas include agriculture, space, medicine, transport, defence, cybersecurity and advanced manufacturing.

SAHMRI building at night

The University of Adelaide is a founding member of SAHMRI, South Australia’s independent, not-for-profit health and medical research institute. Research areas include clinical trials, genetics, Aboriginal health, public health and medical imaging.

International scholarships

The University of Adelaide offers a range of strategic and merit-based scholarships for outstanding Higher Degree by Research applicants.

International student resources

Dr Withawat Withayachumnankul

Why study a research degree with us?

The infrastructure and supports for research students are excellent. I have enjoyed access to a range of services and courses created to promote career development. The staffs are friendly and very helpful.

Dr Withawat Withayachumnankul

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Make history.

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Postgraduate research degrees.

The time you dedicate to a PhD is an investment in yourself and your future. Accelerate your personal development, professional capabilities and career opportunities in ways no other experience can.

Apply for a PhD

We offer over 300 research degree projects across Health, STEM, Agriculture, Energy and many other study areas. 

Why Adelaide?

Top 100 Universities Worldwide

Home to over 110 rhodes scholars, group of eight australia.

Interested in making your own history and pursuing a PhD at the University of Adelaide? Check out what some of our current PhD candidates are achieving.

Getting your PhD brochure

Learn more about how and why to complete your doctorate at South Australia's global, research-intensive university. 

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Find out more about applying for a Postgraduate research degree.

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Faculty of Sciences, Engineering and Technology

Higher Degrees by Research

Whether you intend to work in academia, government or industry, a higher degree by research can give you a competitive edge throughout your career.

With our research areas positioned above world standards * , and six disciplines ranked in the top 50 globally ^ , our internationally renowned academics are at the cutting edge of research and discovery.

By undertaking a research degree with us, you will be involved in discovery, innovation and cutting-edge research. Our strong focus on addressing global challenges creates a highly stimulating setting for our students interested in changing the world.

We provide a stimulating environment for research students. Be part of a thriving research culture which promotes excellence, fosters creativity and catalyses success.

Study options

Join our  Master of Philosophy  or  Doctor of Philosophy  research programs and experience specialised and research-intensive study.

Finding research opportunities

Research degrees in laboratories and groups at the University are highly competitive.

Finding a research project that drives your passion is a two-step process:

  • You need to find an opportunity to work on a project that interests you, and then
  • You will need to find a supervisor to work with.

Your highest chance of success will likely come from identifying areas that are a good ‘fit’ to your own research interests and your previous research experience.

If you find a lab or group that matches the criteria, contact them directly by email to introduce yourself. At this point, you should provide evidence of your academic achievements and, most importantly, details and evidence of your previous research training, such as scientific publications.

Found a research opportunity?

Once you have decided on a research project, an Academic will need to assess your eligibility.

Send the following to your  potential supervisor  or to one of our  Postgraduate Coordinators  for an initial assessment:

  • academic transcripts
  • completed  expression of interest form

Once you have emailed the above to your potential supervisor, you can apply for admission and scholarships through the Adelaide Graduate Research School. 

Admissions and scholarship applications

The  Adelaide Graduate Research School  administers applications for both admission and scholarships (domestic and international).

Scholarships

Scholarships for research degrees are available to international and domestic students. You can increase your chances of gaining a scholarship by having an established list of published research papers in internationally recognised peer-reviewed journals.

Domestic students   International students

Hear from us

Considering taking the next step and studying a Research Degree with us? Check out the recording of our recent info session to hear from a range of speakers what it’s like to undertake a research degree at UoA.

Industry engaged research

Industry engaged research

The University of Adelaide Industry PhD (UAiPhD) is an exceptional and innovative 4 year program, which includes a 6 month industry placement.

Gain valuable understanding about how organisations innovate and solve real world problems, making an impact with your research while gaining a significant employment advantage. 

Find out more

For more information, please contact the Adelaide Graduate Research School

*  2018 Excellence in Research Australia ERA ^  Academic Ranking of World Universities 2020

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Researcher Profiles

Deborah White

Professor Deborah White

Director, Cancer Program and Deputy Theme

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Professor Deborah White PhD FFSc (RCPA)

Professor White is the Director of the Cancer Program and Deputy Precision Medicine Theme Leader at the South Australian Health and Medical Research Institute (SAHMRI) in Adelaide. She is a NHMRC RD Wright Biomedical Research Fellow, a Beat Cancer Prinicpal Research Fellow and Senior Principal Research Fellow with SAHMRI. She is a Professor in Health and Medical Sciences at the University of Adelaide and Health Sciences at Uni SA.

Prof White’s research focus is genomics and rationally targeted therapies in Acute Lymphoblastic Leukaemia (ALL) and Chronic Myeloid Leukaemia (CML) and she holds peer reviewed grants from: The William Lawrence and Blanche Hughes Foundation and the Leukemia Lymphoma Society (USA), the NHMRC, the Leukaemia Foundation Australia (LFA), Channel 7, Cancer Australia, Tour de Cure and the Cancer Council SA (CCSA). Professor White has presented more than 170 papers at scientific meetings, and authored more than 100 scientific publications as well as being an inventor on several international patents.

Professor White is the National Flagship Lead for the ALL Stream of Australian Genomics, and SA scientific lead for Zero Children’s Cancer She is an active member of the National Health & Medical Research Council (NHMRC) being a member of the NHMRC Academy, the Translational Research Program Advisory Committee, and the Women in Health Science (WiHS) Committee. She is a member of the Editorial Board for Cancer Letters.

In 2014 she was recognised as the Australian Society for Medical Research (ASMR) Leading Light for her Medical Research and in 2016 was awarded the University of Adelaide James McWha medal. In 2019 she was awarded a prestigious NHMRC Research Excellence Award and awarded the Beat Cancer Women in Leadership Award in 2020.

  • My Research
  • Publications
  • Grants and Funding
  • Supervision
  • Professional Activities

Leukaemia Research Group  -  Precision Medicine Theme, Cancer Program, SAHMRI

Lead: Professor Deborah White

Email: [email protected]  

A/ RESEARCH PROJECT Brief description of research area.

T-cell Acute Lymphoblastic Leukaemia (T-ALL) is a genomically complex, high-risk disease affecting both children and adults. Novel, targeted treatments are urgently required to prevent drug resistance and relapse. T-ALL is characterised by recurrent gene fusions and concomitant structural abnormalities. Ongoing advances in next generation sequencing (NGS) have enabled classification of a diverse range of genomic alterations resulting in new T-ALL subtypes. Critically, the wealth of genomic information available has identified new and recurrent genomic lesions but their biological and clinical implications remain unclear. Incorporating the knowledge gained through NGS into clinical care presents a major challenge. 

Currently, up to 30% of paediatric/adolescent T-ALL patients relapse with subsequent poor overall survival; the outcome is worse for adult patients with long-term survival rates after relapse below 10%. The over-arching focus of my studies is the generation of patient-derived xenograft (PDX) and transgenic mouse models of T-ALL from patient samples received in the laboratory. These models will be used to (1) examine re-purposing drugs and testing novel therapies; and (2) provide therapeutic options for pre-emptive intervention in the case of therapy-resistant disease. Central nervous system (CNS) involvement is common in relapsed ALL but drivers of this aggressive disease are poorly defined. This project will use imaging studies to track specific disease subtypes demonstrating CNS penetration.

Research Project 1 - Dr Laura Eadie

Title: Evaluation of leukaemic invasion and penetrancein mouse models of ALL.

Project description: 

Our laboratory is the National Referral Centre for genomic screening of ALL cases allowing identification of genomic alterations in a large number of patients.Establishment of PDX models from these patient samples is ongoing. Recent PDXs have resulted in leukaemic engraftment within the brain, indicative of CNS involvement and suggesting an aggressive disease. CNS penetration in ALL is a significant un-met clinical need, however, the pathogenesis of CNS disease, the underlying genomic determinants and the biology driving CNS penetration remain poorly understood and targeted therapies are limited.

Additional PDX models resulted in rapid detection of leukaemic cells within the blood, but not the bone marrow or brain, highlight the complexity of individual leukaemias and the need for real-time disease imaging and tracking. Fluorescently-tagged cells harvested from PDX models or transgenic cells harbouring genomic lesions of interest will be used to investigate CNS involvement. Cells isolated from leukaemic organs will be comprehensively characterised using molecular biology and NGS approaches. Surface receptor expression profiles of leukaemic cells will be examined to determine potential causes of invasion. Computational network biology analyses will be performed to define druggable pathways. Results from this project will inform on disease invasion and allow evaluation of treatment strategies for aggressive disease phenotypes in real-time.

Projects available for:  Mphil / PhD

Location:  SAHMRI

Research project start:  Semester 1 

Special requirements:  Police Clearance

Max Number of Students: 1

Category: Wet Lab

Research Area: Cancer Biology and Clinical Oncology

B/ RESEARCH PROJECT  Brief description of research area.

Acute Lymphoblastic Leukaemia (ALL) is the most common childhood cancer, and leading cause of non-traumatic death in children. For adolescents and young adults (AYA) with ALL the therapeutic outcomes are poor. Most older adults will die of their disease. The recent wealth of genomic information has seen the emergence of new lesions known to confer high-risk, and other recurrent fusions and gene deletions for which the biological and clinical implications remain unclear. Further, recent studies have implicated the human microbiome in ALL development, treatment response and life-long comorbidities. The major challenge is to incorporate knowledge gained through Next Generation Sequencing (NGS) into clinical care and to systematically identify  druggable targets and rational effective therapies to improve patient outcomes. To add to the complexity of therapeutic choice in ALL, immunotherapies (bi-specific T-cell engagers (BiTEs) and CAR-T cells), have shown efficacy in the relapsed/refractory setting, as a transplantation bridge. However, not all high-risk/relapsed ALL patients are eligible for immunotherapy, ~50% of patients experience severe hypersensitivity reactions and the long-term clinical sequelae remains unknown. Our laboratory is the National Referral Centre for genomic screening of ALL cases across all age groups, as such we sequence a large number of patients and have identified a significant number of alterations and novel gene fusions for investigation.

Research Project 2 – 

Title: Cloning acute lymphoblastic leukaemia fusion genes and variants, functional characterisation and therapeutic responses.

Recent advances in genomic profiling have defined B-cell Acute Lymphoblastic Leukeamia (B-ALL) as a heterogeneous disease with multiple subgroups characterised by distinct genetic alterations. Many genomic lesions in B-ALL are associated with alterations of cytokine receptors or their signaling pathway mediators, transcription factors or regulators of differentiation.Genomic lesions in ALL patients stratify with prognosis and using transcriptomic analysis, we have identified a number of poorly characterisedfusion genes and variants in patients.  This project aims to clone full-length fusion-genes and gene variants from patient material into mammalian expression plasmids.  This will allow  in vitro characterisation in cell line models of aberrant signalling pathways that drive disease and assess therapeutic responses. This project will involve a range of molecular biology and cloning techniques including primer design, PCR Sanger sequencing, bacterial work, tissue culture and flow cytometry.

Projects available for:  Third Year (Basic Science) / Honours 

Research project start:  Semester 1

Special requirements: Police Clearance

Research Project 3 – Dr Sue Heatley

Title: Investigation of resistance mechanisms to the bispecific T-cell engager (BiTE)  blinatumomab in relapsed acute lymphoblastic leukaemia.

Recently, a new compound of drug known as Bispecific T-cell engager (BiTE) has been approved for use in B-ALL by the Food and Drug Administration (FDA) and is currently undergoing clinical trials in Australia. Blinatumomab is a BiTE that enables an immunological response between the CD19 positive leukaemic cell and a cytotoxic CD3 positive T-cell. While the introduction of blinatumomab promises to be an exciting addition to the clinical arsenal, initial response rates in relapsed/refractory ALL have been ~43% and, as with other treatments, resistance is likely to occur. Immune evasion is a likely cause of resistance as well as loss of the CD19 target, leading to CD19 negative relapse and further investigation is warranted.

Relapsed patient samples that are identified as being treated with blinatumomab will be flow sorted by CD19 positivity. CD19 positive and CD19 negative populations will undergo mRNAseq to identify if a lineage switch has occurred and if the driving event is now present in the CD19 negative population. Differences in gene expression will also be interrogated.

Resistance will be modelled  in-vitro by subjecting fusion constructs to incrementally increasing doses of blinatumomab, enabling further examination of potential immune evasion pathways. 

Projects available for:  Honours / Mphil / PhD

Appointments

Date Position Institution name
2017 - ongoing Adjunct Professor Faculty of Health Sciences University of South Australia, Adelaide
2015 - ongoing Deputy Theme Leader (Precision Medicine) & Director of Cancer Research South Australian Health and Medical Research Institute
2015 - ongoing Affiliate Professor Medicine University of Adelaide
2015 - ongoing Affiliate Professor Paediatrics University of Adelaide
2015 - ongoing Affiliate Professor University of Adelaide
2015 - ongoing Principal Research Fellow South Australian Health and Medical Research Institute
2015 - ongoing Group Leader South Australian Health and Medical Research Institute
2013 - ongoing Director of Cancer Research South Australian Health and Medical Research Institute
2013 - ongoing Principal Research Fellow South Australian Health and Medical Research Institute
2013 - ongoing Affiliate Professor Medicine University of Adelaide
2013 - ongoing Affiliate Professor Pediatrics University of Adelaide
2013 - ongoing Director of Cancer Research South Australian Health and Medical Research Institute, Adelaide
2013 - ongoing Principal Research Fellow South Australian Health and Medical Research Faculty
2013 - ongoing Faculty Member SA Pathology
2011 - ongoing Head of Research SA Pathology
2011 - ongoing Adjunct Associate Professor University of South Australia
2011 - ongoing Affiliate Associate Professor Medicine University of Adelaide
2011 - ongoing Chief Medical Scientist and Scientific Head University of Adelaide
2000 - ongoing Chief Medical Technician SA Pathology

Awards and Achievements

Date Type Title Institution Name Country Amount
2021 Award Beat Cancer Women in Leadership Award Cancer Council Australia -
2019 Fellowship NHMRC Research Excellence Award NHMRC Australia -
2017 Award Light the Night Blue Ambassador. Leukaemia Foundation of Australia Australia -
2016 Award Shortlisted Candidate National Academy of Science Gottschalk Medal - - -
2016 Award Finalist Winnovation Award (Science and Medicine Category) - - -
2016 Award 2016 James McWha Medalist - - -
2014 Award Australian Society for Medical Research (ASMR) Leading Light for 2014 - - -
2013 Award 2013 Abstract accepted for the Presidential Symposium - - -
2012 Award 2012 Abstract accepted for the Presidential Symposium - - -
2011 Recognition Member of the Chief Investigative Team recognized by the NHMRC for one of the “Ten of the Best Project Grants” - Australia -
2011 Award Centre for Cancer Biology Prize for Highest Impact Paper 2009-2010 - Australia -
2009 Distinction Hanson Centre Clinical Researcher of the Year - Australia -
1994 Award Travel Award for Outstanding Young Scientific Investigators Health Science Alliance Australia -
1992 Award Travel Award for Outstanding Young Scientific Investigators Health Science Alliance Australia -
1988 Recognition Outstanding Achievement in the field of Haematology University of South Australia - -
1987 Award Travel Award for Outstanding Young Scientific Investigators Health Science Alliance Australia -
Date Institution name Country Title
2011 Faculty of Science Royal College of Pathologists Australia FFSc RCPA, Founding Fellow
2008 The University of Adelaide Australia PhD

Research Interests

Year Citation
2024 Eadie, L. N., Lagonik, E., Page, E. C., Schutz, C. E., Heatley, S. L., McClure, B. J., . . . White, D. L. (2024). Asciminib is a novel inhibitor of ABL1 and ABL2 gene fusions in ALL but requires the ABL SH3 domain for efficacy. , (9), 1022-1026.
Europe PMC1
2024 Ma, S. B., Lin, W., Campbell, J., Clerici, K., White, D., Yeung, D., . . . Agarwal, R. (2024). Laboratory validation and clinical utility of next-generation sequencing-based IGH/TCR clonality testing for the monitoring of measurable residual disease in acute lymphoblastic leukaemia: real-world experience at Austin Pathology. , S0031-3025(24)00171-5.
2024 Thompson, J., Thompson, G., White, D., & Yeung, D. (2024). Judicious use of precise fluorescence in situ hybridisation panels guided by population prevalence may assist pragmatic detection of clinically targetable Philadelphia chromosome-like acute lymphoblastic leukaemia fusions: a systematic review. , S0031-3025(24)00227-7.
2023 , , 1177871.
Scopus4 Europe PMC1
2023 , (2), 282-287.
Europe PMC1
2023 , (1), 1-12.
2023 , (1), 1-9.
2023 , (19), 4731-1-4731-13.
Scopus2 Europe PMC1
2023 Nunn, J., Adayapalam, N., Riyat, S., Seymour, L., Williams, B., Rehn, J., . . . Tsuchiya, K. (2023). Paediatric B lymphoblastic leukaemia with hyperdiploidy and a false-positive KMT2A fluorescence in situ hybridization result. , , 80-83.
2023 , (3), 419-426.
Scopus13 WoS4 Europe PMC11
2023 , (2), 264-1-264-11.
Scopus1
2023 , (4), 3553-1-3553-14.
2022 , (10), 1-23.
Scopus12 WoS5 Europe PMC11
2022 , (3), 700-705.
Scopus3 WoS2 Europe PMC1
2022 , (1), 13-27.
Scopus15 WoS7 Europe PMC7
2022 , (6), 797-808.
Scopus13 WoS5 Europe PMC10
2022 , (6), 1407-1411.
Scopus3 WoS2 Europe PMC2
2022 , (8-9), 1140-1152.
Scopus6 WoS2 Europe PMC5
2022 , (24), 3519-3531.
Scopus21 WoS12 Europe PMC16
2022 Forgione, M. O., McClure, B. J., Page, E. C., Yeung, D. T., Eadie, L. N., & White, D. L. (2022). TP53 loss‑of‑function mutations reduce sensitivity of acute leukaemia to the curaxin CBL0137.. , (5), 1-7.
Scopus1 Europe PMC1
2022 , (9), 1-17.
Scopus9 WoS3 Europe PMC8
2022 , , 851572-1-851572-6.
Scopus1 WoS1 Europe PMC1
2022 Venn, N. C., Huang, L., Hovorková, L., Muskovic, W., Wong, M., Law, T., . . . Sutton, R. (2022). Measurable residual disease analysis in paediatric acute lymphoblastic leukaemia patients with ABL-class fusions. , (5), 908-915.
Scopus4 Europe PMC4
2022 , , 1-34.
Scopus16 WoS8 Europe PMC10
2021 Mallik, S., Yeung, D., Rehn, J., Nguyen, T., Dunlop, L., Kwan, J., & White, D. (2021). Monocytoid switch in an adult with B-cell precursor acute lymphoblastic leukaemia characterised by the PAX5 P80R mutation. , (5), 631-634.
Scopus1
2021 , (12), 100464-1-100464-e9.
Scopus20 WoS10 Europe PMC17
2021 El Khawanky, N., Hughes, A., Yu, W., Myburgh, R., Matschulla, T., Taromi, S., . . . Zeiser, R. (2021). Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia. , (1), 6436-1-6436-20.
Scopus57 WoS30 Europe PMC43
2021 , (5), 1157-1166.
Scopus3
2021 , (1), 171-175.
Scopus4 WoS1 Europe PMC3
2021 , (5), 526-536.
Scopus4 WoS1 Europe PMC3
2021 , (5), 1-7.
Scopus16 WoS15 Europe PMC10
2021 , (1), 1-13.
Scopus15 WoS8 Europe PMC10
2021 , , 28-37.
Scopus10 WoS8 Europe PMC6
2020 , (3), 433-441.
Scopus52 WoS37 Europe PMC36
2020 , (12), 709-721.
Scopus9 WoS7 Europe PMC5
2020 , (2), 301-304.
Scopus2 WoS1 Europe PMC1
2020 , (10), 1-15.
Scopus13 WoS8 Europe PMC11
2020 , (12), 3738-1-3738-19.
Scopus9 WoS9 Europe PMC8
2020 Cario, G., Leoni, V., Conter, V., Attarbaschi, A., Zaliova, M., Sramkova, L., . . . Biondi, A. (2020). Relapses and treatment-related events contributed equally to poor prognosis in children with ABL-class fusion positive B-cell acute lymphoblastic leukemia treated according to AIEOP-BFM protocols.. , (7), 1887-1894.
Scopus37 WoS26 Europe PMC22
2020 , (4), 1052-1061.
Scopus38 WoS29 Europe PMC21
2019 Tavakoli Shirazi, P., Eadie, L. N., Heatley, S. L., Hughes, T. P., Yeung, D. T., & White, D. L. (2019). The effect of co-occurring lesions on leukaemogenesis and drug response in T-ALL and ETP-ALL.. , (4), 455-464.
Scopus7 WoS6 Europe PMC6
2019 , , 410-418.
Scopus32 WoS22 Europe PMC17
2019 , (3), e56-e60.
Scopus11 WoS7 Europe PMC8
2019 , (10), 1610-1621.
Scopus25 WoS24 Europe PMC22
2018 , (12), 2572-2579.
Scopus62 WoS46 Europe PMC34
2018 , , 69-74.
Scopus5 WoS4 Europe PMC3
2018 , (9), 948-961.
Scopus146 WoS121 Europe PMC101
2018 , (78), 34735-34747.
Scopus16 Europe PMC5
2018 , (12), 2026-2032.
Scopus32 WoS20 Europe PMC16
2018 Eadie, L. N., Hughes, T. P., & White, D. L. (2018). Patients with low OCT-1 activity and high ABCB1 fold rise have poor long-term outcomes in response to tyrosine kinase inhibitor therapy. , (10), 2288-2291.
Scopus11 WoS10 Europe PMC4
2018 , (1), 24.
Scopus34 WoS27 Europe PMC25
2018 , (1), e0192180-1-e0192180-18.
Scopus20 WoS13 Europe PMC14
2018 Eadie, L., Saunders, V., Branford, S., White, D., & Hughes, T. (2018). The new allosteric inhibitor asciminib is susceptible to resistance mediated by ABCB1 and ABCG2 overexpression in vitro. , (17), 13423-13437.
Scopus38 Europe PMC20
2018 , (7), 1000-1004.
Scopus30 WoS25 Europe PMC22
2017 , (5), 711-721.
Scopus6 WoS5 Europe PMC5
2017 , , 86-90.
Scopus10 WoS9 Europe PMC8
2017 , , 92-101.
Scopus18 WoS18 Europe PMC14
2017 , (12), e490-e493.
Scopus49 WoS44 Europe PMC25
2017 Eadie, L., Hughes, T., & White, D. (2017). Response to 'Overexpression of ABCB1 as prediction marker for CML: How close we are to translation into clinics?'. , (3), 769-770.
2017 Eadie, L. N., Dang, P., Saunders, V. A., Yeung, D. T., Osborn, M. P., Grigg, A. P., . . . White, D. L. (2017). The clinical significance of ABCB1 overexpression in predicting outcome of CML patients undergoing first-line imatinib treatment. , (1), 75-82.
Scopus52 WoS51 Europe PMC39
2017 , (2), 175-184.
Scopus33 WoS25 Europe PMC18
2017 , (8), 977-985.
Scopus20 WoS17 Europe PMC13
2017 , (9), 1166-1176.
Scopus146 WoS122 Europe PMC95
2017 , (1), 1-23.
Scopus5 WoS3 Europe PMC3
2017 , (5), 843-853.
Scopus10 WoS11 Europe PMC4
2016 Trahair, T., Lock, R., Sutton, R., Sia, K., Evans, K., Richmond, J., . . . Revesz, T. (2016). Xenograft-directed personalized therapy for a patient with post-transplant relapse of ALL. , (9), 1279-1282.
Scopus5 WoS5 Europe PMC4
2016 , (33), 53064-53073.
Scopus9 WoS9 Europe PMC6
2016 , (8), e0161470-1-e0161470-18.
Scopus35 WoS26 Europe PMC24
2016 White, D. (2016). Acute sensitivity of Ph-like acute lymphoblastic leukemia to the SMAC-mimetic birinapant. , (15), 4579-4591.
Scopus19 WoS17 Europe PMC14
2016 Dolai, S., Sia, K., Robbins, A., Zhong, L., Heatley, S., Vincent, T., . . . Lock, R. (2016). Quantitative phosphotyrosine profiling of patient-derived xenografts identifies therapeutic targets in pediatric leukemia. , (9), 2766-2777.
Scopus12 WoS13 Europe PMC9
2016 , (9), 817-821.
Scopus9 WoS9 Europe PMC5
2016 , (6), 1263-1272.
Scopus41 WoS32 Europe PMC24
2016 Sadras, T., D'Andrea, R., & White, D. (2016). The Role of Wnt/β -Catenin Signaling in Normal and Malignant Hematopoiesis, Hemostasis. , (1), 1-9.
2015 , (25), 2720-2723.
Scopus26 WoS22 Europe PMC18
2015 Watkins, D., Hughes, T., & White, D. (2015). OCT1 and imatinib transport in CML: Is it clinically relevant?. , (10), 1960-1969.
Scopus49 WoS40 Europe PMC25
2015 White, D. L., & Hughes, T. P. (2015). Living with CML: Is death no longer the end (point)?. , (1), 2-4.
Scopus1 WoS1 Europe PMC5
2015 Yeung, D., Moulton, D., Heatley, S., Nievergall, E., Dang, P., Braley, J., . . . White, D. (2015). Relapse of BCR-ABL1-like ALL mediated by the ABL1 kinase domain mutation T315I following initial response to dasatinib treatment. , (1), 230-232.
Scopus24 WoS20 Europe PMC14
2015 , (6), 915-923.
Scopus81 WoS67 Europe PMC47
2015 , (2), 185-192.
Scopus21 WoS16 Europe PMC10
2015 Lu, L., Saunders, V., Leclercq, T., Hughes, T., & White, D. (2015). Ponatinib is not transported by ABCB1, ABCG2 or OCT-1 in CML cells. , (8), 1792-1794.
Scopus20 WoS22 Europe PMC16
2015 , (1), 76-85.
Scopus28 WoS27 Europe PMC23
2014 Kok, C. H., Leclercq, T., Watkins, D. B., Saunders, V., Wang, J., Hughes, T. P., & White, D. L. (2014). Elevated PTPN2 expression is associated with inferior molecular response in de-novo chronic myeloid leukaemia patients. , (3), 702-705.
Scopus6 WoS4 Europe PMC5
2014 , (11), 1005-1015.
Scopus1101 WoS927 Europe PMC754
2014 , (3), 294-306.
Scopus70 WoS60 Europe PMC51
2014 , (8), 1218-1228.
Scopus85 WoS77 Europe PMC63
2014 Dolai, S., Sia, K. C. S., Robbins, A. K., Zhong, L., Heatley, S., Vincent, T., . . . Lock, R. B. (2014). Targeted Cancer Therapy in High-Risk Pediatric Leukemia Using Global Phosphotyrosine Profiling. , (21), 3 pages.
2013 , (5), 631-639.
Scopus34 WoS30 Europe PMC22
2013 , (4), 515-522.
Scopus610 WoS542 Europe PMC431
2013 , (6), 1427-1430.
Scopus11 WoS12 Europe PMC11
2013 , (6), 896-900.
Scopus8 WoS9 Europe PMC7
2013 , (5), 1201-1204.
Scopus8 WoS7 Europe PMC6
2013 , (2), 489-490.
Scopus11 WoS8 Europe PMC8
2013 , (3), 569-578.
Scopus24 WoS21 Europe PMC21
2013 , (1), 198-201.
Scopus27 WoS21 Europe PMC16
2013 , (21), 2705.
WoS1
2013 , (1), 168-175.
Scopus44 WoS37 Europe PMC27
2013 , (2), 193-200.
Scopus91 WoS85 Europe PMC69
2012 , (17), 4300-4303.
2012 , (6), 907-914.
Scopus52 WoS45 Europe PMC35
2012 , (11), 1772-1778.
Scopus19 WoS18 Europe PMC15
2012 , (10), 1144-1145.
Scopus14 WoS9 Europe PMC8
2011 , (13), 3634-3644.
Scopus46 WoS40 Europe PMC35
2011 , (11), 2139-2147.
Scopus52 WoS46 Europe PMC38
2011 , (3), 285-299.
Scopus6 WoS6 Europe PMC5
2011 , (4), 608-611.
Scopus10 WoS9 Europe PMC7
2011 , (2), 1-33.
Scopus13 WoS12 Europe PMC11
2011 , (2), 165-167.
2011 White, D., & Hughes, T. (2011). Predicting the response of CML patients to tyrosine kinase inhibitor therapy. , (2), 88-95.
Scopus7 WoS7 Europe PMC6
2010 White, D. L., Saunders, V. A., Dang, P., Engler, J., & Hughes, T. P. (2010). OCT-1 activity measurement provides a superior imatinib response predictor than screening for single-nucleotide polymorphisms of OCT-1. , (11), 1962-1965.
Scopus36 WoS34 Europe PMC24
2010 , (15), 2776-2778.
Scopus20 WoS18 Europe PMC12
2010 , (8), 3763-3767.
Scopus50 WoS46 Europe PMC41
2010 , (4), 771-778.
Scopus48 WoS42 Europe PMC33
2010 , (16), 2761-2767.
Scopus157 WoS142 Europe PMC111
2010 , (4), 855-857.
Scopus9 WoS8 Europe PMC9
2010 , (4), 765-770.
Scopus55 WoS52 Europe PMC40
2010 , (3), 658-660.
Scopus27 WoS25 Europe PMC22
2009 , (2), 59-65.
Scopus6 Europe PMC5
2009 Hiwase, D., White, D., Saunders, V., Kumar, S., Melo, J., & Hughes, T. (2009). Short-term intense Bcr-Abl kinase inhibition with nilotinib is adequate to trigger cell death in BCR-ABL<sup>+</sup> cells. , (6), 1205-1206.
Scopus16 WoS15 Europe PMC11
2008 Hughes, T. P., Branford, S., White, D. L., Reynolds, J., Koelmeyer, R., Seymour, J. F., . . . Grigg, A. (2008). Impact of early dose intensity on cytogenetic and molecular responses in chronicphase CMLpatients receiving 600 mg/day of imatinib as initial therapy. , (10), 3965-3973.
Scopus145 WoS135 Europe PMC116
2008 , (12), 3881-3888.
Scopus166 WoS145 Europe PMC124
2008 , (7191), 110-114.
Scopus875 WoS783 Europe PMC677
2008 White, D. L. (2008). Is telomerase a player in chronic phase chronic myeloid leukemia, disease progression and imatinib resistance?. , (6), 1022-1023.
2007 , (12), 4064-4072.
Scopus278 WoS255 Europe PMC196
2007 , (28), 4445-4451.
Scopus54 WoS52 Europe PMC48
2007 , (8), 3609-3610.
Scopus41 WoS44 Europe PMC30
2006 , (2), 697-704.
Scopus385 WoS322 Europe PMC255
2005 , (7), 2520-2526.
Scopus124 WoS109 Europe PMC90
2003 , (6), 534-541.
Scopus2 WoS2 Europe PMC2
2003 , (5), 821-828.
Scopus40 WoS33 Europe PMC26
2000 , , 10-11.
1997 , (3), 289-293.
Scopus9 WoS10 Europe PMC7
1995 , (6), 641-644.
Scopus41 WoS38 Europe PMC23
1995 , (5), 818-821.
Scopus4 WoS3
1994 HUGHES, T. P., WHITE, D. L., HAYLOCK, D. N., TURCZYNOWICZ, S., HUTCHINS, C. J., TO, L. B., & JUTTNER, C. A. (1994). CYTOKINE SUPPORTED CULTURE OF CD34+ CELLS FROM AML PATIENTS RESULTS IN EXPANSION OF BOTH LEUKEMIC AND NORMAL PROGENITORS. , (10), A52.
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1989 HUTCHINS, C., CASEY, G., WHITE, D., MOORE, S., RUDZKI, Z., & KIMBER, R. (1989). DETECTION OF REARRANGEMENT WITHIN THE BREAKPOINT CLUSTER REGION OF CHROMOSOME 22 IN THE DIAGNOSIS OF CHRONIC MYELOID LEUKEMIA. , (5), 443-448.
1987 White, D. L., Ashman, L. K., Dart, G. W., Zola, H., Toogood, I. R. G., & Kimber, R. J. (1987). The expression of mature myeloid cell differentiation markers in acute leukemia. , (2), 137-142.
Scopus10 WoS12 Europe PMC5
1987 Ashman, L. K., White, D., Zola, H., & Dart, G. W. (1987). Expression of the non-T ALL-associated p24 antigen on leukaemic blasts from patients with ANLL. , (1), 97-101.
Scopus5 WoS8 Europe PMC6
Year Citation
2020 Tavakoli, P. S., Eadie, L., Heatley, S. L., Yeung, D. T., & White, D. L. (2020). The MYB-TYK2 gene fusion induces B-cell acute lymphoblastic leukaemia in in vitro and in vivo models and can be effectively targeted by the dual SYK/JAK inhibitor, cerdulatinib (Vol. 4). Lippincott, Williams & Wilkins.

Conference Papers

Year Citation
2023 White, D. L., Rehn, J. A., Schutz, C. E., Heatley, S. L., Eadie, L. N., Thomson, A., . . . Greenwood, M. (2023). Improved MRD Negativity Rates in Adverse Genomic Risk B-ALL Patients with Chemotherapy / Blinatumomab Induction: Experience from the Australasian Leukaemia Lymphoma Group (ALLG) ALL06/09 Studies. In BLOOD Vol. 142 (pp. 6 pages). CA, San Diego: AMER SOC HEMATOLOGY.
2023 Eadie, L. N., Schutz, C. E., Page, E. C., Conlin, T. S., Heatley, S. L., Lagonik, E., . . . White, D. L. (2023). Asciminib Is Effective Against ABL1 Gene Fusions in Acute Lymphoblastic Leukemia but Only When the ABL1 SH3 Domain Is Present. In BLOOD Vol. 142 (pp. 4 pages). CA, San Diego: AMER SOC HEMATOLOGY.
2022 Poudel, G., Yeung, D. T., White, D. L., Hughes, T., & Pagani, I. S. (2022). <i>PTPN11</i> Mutations Drive Tyrosine Kinase Inhibitor As Well As Venetoclax Resistance in Ph plus ALL Cells, but Are Sensitive to the Combination. In BLOOD Vol. 140 (pp. 3128-3129). LA, New Orleans: AMER SOC HEMATOLOGY.
2021 Page, E. C., Heatley, S. L., Rehn, J., Yeung, D. T., Thomas, P. Q., & White, D. L. (2021). <i>HMGN1</i> expression Predisposes Down Syndrome Patients to Develop <i>P2RY8-CRLF2</i> acute Lymphoblastic Leukemia. In BLOOD Vol. 138 (pp. 4 pages). Atlanta, GA: AMER SOC HEMATOLOGY.
2018 Leow, B. C., Eadie, L., Pagani, I. S., Yeung, D. T., Hughes, T. P., & White, D. L. (2018). Clonal Selection Determines Resultant Dominance of Tyrosine Kinase Inhibitor-Resistant Cells in Chronic Myeloid Leukaemia. In HemaSphere Vol. 2 (pp. 503). Stockholm, Sweden: Lippincott, Williams & Wilkins.
2018 Chan, L. N., Shojaee, S., Hurtz, C., Auer, F., Chen, Z., Cosgun, K. N., . . . Muschen, M. (2018). Divergent Evolutionary Trajectories of Erkand Stat5-Activating Lesions in Acute Lymphoblastic Leukemia. In BLOOD Vol. 132 (pp. 2 pages). San Diego, CA: AMER SOC HEMATOLOGY.
2018 Yeung, D. T., Grigg, A. P., Shanmuganathan, N., Cunningham, I., Shortt, J., Rowling, P., . . . Hughes, T. P. (2018). Combination of Nilotinib and Pegylated Interferon Alfa-2b Results in High Molecular Response Rates in Chronic Phase CML: Interim Results of the ALLG CML 11 Pinnacle Study. In BLOOD Vol. 132 (pp. 5 pages). San Diego, CA: AMER SOC HEMATOLOGY.
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2017 Ross, D. M., Pagani, I. S., Shanmuganathan, N., Seymour, J. F., Mills, A. K., Filshie, R. J., . . . Hughes, T. P. (2017). Long-term Follow-up of the ALLG CML8 TWISTER Study of Treatment-free Remission (TFR) in Patients With Chronic Myeloid Leukemia (CML).. In Blood Vol. 130 (pp. 1597). Atlanta: American Society of Hematology.
2016 Pagani, I. S., Kok, C. H., Saunders, V., Goyne, J., McLean, J., VanderHoek, M., . . . Ross, D. M. (2016). The genomic landscape of mitochondrial DNA mutations in chronic myeloid leukaemia.. In European Journal of Human Genetics. Barcelona: Natue Publishing Group.
2016 Asari, K., Heatley, S. L., Sadras, T., Leclercq, T. M., Fitter, S., Kok, C. H., . . . White, D. L. (2016). <i>In Vitro</i> Modeling of Ph-like ALL Fusions Identifies Novel Kinase-Domain Mutations As Mode of TKI-Resistance Implications for Targeted Therapy. In BLOOD Vol. 128 (pp. 5 pages). San Diego, CA: AMER SOC HEMATOLOGY.
2016 Yeung, D. T., Osborn, M. P., White, D. L., Branford, S., Gerber, T., Butcher, B., . . . Hughes, T. P. (2016). Upfront Imatinib with Selective Early Switching to Nilotinib Leads to Excellent Achievement of Deep Molecular Response in Chronic Phase CML: 5 Year (Final) Analysis of the TIDEL-II Study. In BLOOD Vol. 128 (pp. 6 pages). San Diego, CA: AMER SOC HEMATOLOGY.
2016
Scopus70 WoS44 Europe PMC45
2016 Pagani, I. S., Kok, C. H., Wang, J., Saunders, V., Goyne, J., McLean, J., . . . Ross, D. M. (2016). MITOCHONDRIAL DNA MUTATIONS IDENTIFY CLONAL HETEROGENEITY IN CHRONIC MYELOID LEUKAEMIA. In HAEMATOLOGICA Vol. 101 (pp. 234). Copenhagen, DENMARK: FERRATA STORTI FOUNDATION.
2016 Lu, L., Saunders, V., Kok, C., Leclercq, T., Hughes, T., & White, D. (2016). MODELLING PONATINIB RESISTANCE IN BCR-ABL1+CELL LINES: IMPLICATIONS FOR PONATINIB THERAPY. In HAEMATOLOGICA Vol. 101 (pp. 182-183). Copenhagen, DENMARK: FERRATA STORTI FOUNDATION.
2015 Eadie, L. N., Hughes, T. P., & White, D. L. (2015). The Clinical Significance of Early Imatinib Induced ABCB1 Overexpression in Chronic Phase CML Patients: A TIDEL II Sub-Study. In BLOOD Vol. 126 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY.
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2015 Kok, C. H., Leclercq, T. M., Watkins, D., Yeung, D. T., Saunders, V. A., White, D. L., & Hughes, T. P. (2015). A 20 Gene Expression Signature That Predicts Early Molecular Response Failure in Chronic Phase CML Patients Treated with Frontline Imatinib. In BLOOD Vol. 126 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY.
2015 Eadie, L. N., Saunders, V. A., Leclercq, T. M., Branford, S., White, D. L., & Hughes, T. P. (2015). The Allosteric Inhibitor ABL001 Is Susceptible to Resistance in Vitro Mediated By Overexpression of the Drug Efflux Transporters ABCB1 and ABCG2. In BLOOD Vol. 126 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY.
2015 Wang, J., Kok, C. H., Leclercq, T. M., Saunders, V. A., D'Andrea, R. J., Hughes, T. P., & White, D. L. (2015). High Peroxisome Proliferator-Activated Receptor-Gamma (PPARγle) Transcriptional Activity Reduces Active Influx of Imatinib and Kinase Inhibition in CML Cells. In BLOOD Vol. 126 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY.
2014 Eadie, L. N., Hughes, T. P., & White, D. L. (2014). Increasing expression of the efflux transporter ABCB1 may predispose CML cells to over TKI resistance. In NDLR Abstract Handbook Vol. 122 (pp. 2 pages). Noosa, QLD: AMER SOC HEMATOLOGY.
2013 White, D., Saunders, V., Eadie, L., David, Y., & Hughes, T. P. (2013). The Depth Of In Vivo Kinase Inhibition Achieved Over The First Month Of Nilotinib Therapy Predicts For Subsequent Molecular Response, and Is Closely Related To Nilotinib Plasma Levels. In Blood Vol. 122 (pp. 256). American Society of Hematology.
2013 Eadie, L., Hughes, T. P., & White, D. L. (2013). Increasing expression of the efflux transporter ABCB1 may predispose CML cells to overt TKI resistance. In Blood Vol. 122 (pp. 5157). New Orleans, Louisiana: American Society of Hematology.
2013 Gordon, J. E. A., Bailey, C. G., Rasko, J., Ritchie, W., Watkins, D. B., White, D. L., . . . Hughes, T. P. (2013). MicroRNA Dysregulation in Newly Diagnosed Chronic Myeloid Leukaemia Patients. In BLOOD Vol. 122 (pp. 1 page). New Orleans, LA: AMER SOC HEMATOLOGY.
2011 White, D. L., Saunders, V. A., Frede, A., GrootObbink, K., Slader, C., Yeung, D. T., . . . Hughes, T. P. (2011). The Strategy of Early Nilotinib Switch Based on Failure to Achieve Optimal Molecular Targets on Imatinib May Not Overcome the Negative Impact of a Low OCT-1 Activity in De-Novo CP-CML Patients. In BLOOD Vol. 118 (pp. 735). San Diego, CA: AMER SOC HEMATOLOGY.
2011 Yeung, D. T., Osborn, M., White, D. L., Branford, S., Kornhauser, M., Slader, C., . . . Hughes, T. P. (2011). Upfront Imatinib Therapy in CML Patients with Rapid Switching to Nilotinib for Failure to Achieve Molecular Targets or Intolerance Achieves High Overall Rates of Molecular Response and a Low Risk of Progression - An Update of the TIDEL-II Trial. In BLOOD Vol. 118 (pp. 208). San Diego, CA: AMER SOC HEMATOLOGY.
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2011 Watkins, D. B., Kok, C. H., Hughes, T. P., Slader, C., D'Andrea, R., & White, D. L. (2011). Differential Lineage Involvement Between Very Low and Higher OCT-1 Activity Chronic-Phase CML Patients. In BLOOD Vol. 118 (pp. 727). San Diego, CA: AMER SOC HEMATOLOGY.
2011 Nievergall, E., White, D. L., Ramshaw, H., Lopez, A. F., Hughes, T. P., & Hiwase, D. K. (2011). Antibody-Targeting of IL-3 Receptor-α Increases the Susceptibility of CD34<SUP>+</SUP> CML Progenitors to Dasatinib-Induced Cell Death. In BLOOD Vol. 118 (pp. 1599). San Diego, CA: AMER SOC HEMATOLOGY.
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2011 Wang, J., Hughes, T. P., Kok, C. H., Saunders, V. A., Frede, A., GrootObbink, K., . . . White, D. L. (2011). Non-Steroidal Anti-Inflammatory Drugs and Imatinib; Drug Interactions That May Impact Efficacy. In BLOOD Vol. 118 (pp. 1493-1494). San Diego, CA: AMER SOC HEMATOLOGY.
2011 White, D. L., Lu, L., Clackson, T. P., Saunders, V. A., & Hughes, T. P. (2011). ATP Dependent Efflux Transporters ABCB1 and ABCG2 Are Unlikely to Impact the Efficacy, or Mediate Resistance to the Tyrosine Kinase Inhibitor, Ponatinib. In BLOOD Vol. 118 (pp. 1180). San Diego, CA: AMER SOC HEMATOLOGY.
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2010 Soverini, S., Angelini, S., Turrini, E., Burnett, M., Ravegnini, G., Thornquist, M., . . . Martinelli, G. (2010). Specific Drug Transporter Genotypes Are Significantly Associated with Increased Rates of Major and Complete Molecular Responses In Newly Diagnosed Chronic Myeloid Leukemia Patients Treated with Imatinib - A TOPS Correlative Substudy. In BLOOD Vol. 116 (pp. 293-294). Orlando, FL: AMER SOC HEMATOLOGY.
2010 Tang, C., Schafranek, L., Watkins, D., Parker, W. T., Prime, J., White, D. L., & Hughes, T. (2010). Modelling of TKI Resistance In CML Cell Lines: Kinase Domain Mutations Usually Arise In the Setting of BCR-ABL Overexpression. In BLOOD Vol. 116 (pp. 1385). Orlando, FL: AMER SOC HEMATOLOGY.
2010 White, D. L., Saunders, V., Andrew, M., Rofe, A., Slader, C., Yeung, D. T., . . . Hughes, T. (2010). Imatinib PK: Observations From the TIDEL II Study.. In BLOOD Vol. 116 (pp. 943). Orlando, FL: AMER SOC HEMATOLOGY.
2010 White, D. L., Saunders, V., Frede, A., GrootObbink, K., Slader, C., Yeung, D. T., . . . Hughes, T. (2010). Early Switching From Imatinib to Nilotinib In CML Patients Failing to Achieve Early Molecular Targets May Not Be An Effective Approach In Patients with Very Low OCT-1 Activity: A TIDEL II Sub-Study. In BLOOD Vol. 116 (pp. 160-161). Orlando, FL: AMER SOC HEMATOLOGY.
2010 Yeung, D. T., Osborn, M., White, D. L., Branford, S., Haswell, L., Slader, C., . . . Hughes, T. (2010). Selective Escalation of Imatinib Therapy and Early Switching to Nilotinib In De Novo Chronic Phase CML Patients: Interim Results From the TIDEL-II Trial. In BLOOD Vol. 116 (pp. 96). Orlando, FL: AMER SOC HEMATOLOGY.
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2010
2010 Hiwase, D. K., Eadie, L., Saunders, V., Hughes, T., & White, D. L. (2010). Proton Pump Inhibitors Augment Nilotinib and Dasatinib Mediated Bcr-Abl Kinase Inhibition. In Blood Vol. 116 (pp. 3991). American Society of Hematology.
2010 Hiwase, D. K., Engler, J., Saunders, V., White, D. L., & Hughes, T. (2010). In Contrast to Imatinib, Dasatinib Intracellular Concentration In CML-CD34<SUP>+</SUP> Progenitors Is Not Significantly Different Than That Observed In CD34<SUP>-</SUP> Mature Cells.. In BLOOD Vol. 116 (pp. 517). Orlando, FL: AMER SOC HEMATOLOGY.
2010 Hiwase, D. K., Eadie, L., Saunders, V., Hughes, T., & White, D. L. (2010). Proton Pump Inhibitors Augment Nilotinib and Dasatinib Mediated Bcr-Abl Kinase Inhibition.. In BLOOD Vol. 116 (pp. 1626-1627). Orlando, FL: AMER SOC HEMATOLOGY.
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2009 Osborn, M. P., Branford, S., White, D. L., Seymour, J. F., Columbus, R., Taylor, K., . . . Hughes, T. P. (2009). Maintaining Imatinib ≥600 Mg Daily in the First 12 Months of Chronic Phase CML Treatment Is Associated with Superior Event-Free Survival at 5 Years.. In BLOOD Vol. 114 (pp. 461-462). New Orleans, LA: AMER SOC HEMATOLOGY.
2009 Hiwase, D. K., White, D. L., Powell, J. A., Saunders, V. A., Zrim, S., Frede, A., . . . Hughes, T. (2009). Blocking of Cytokine Survival Signals along with Intense Bcr-Abl Kinase Inhibition May Eradicate CML Progenitor Cells. In BLOOD Vol. 114 (pp. 1258-1259). New Orleans, LA: AMER SOC HEMATOLOGY.
2009 White, D. L., Saunders, V. A., Frede, A., Dang, P., Zrim, S., Osborn, M. P., . . . Hughes, T. (2009). The Functional Activity of the OCT-1 Protein Is Predictive of Molecular Response and Survival in CP-CML Patients Treated with Imatinib: A 5 Year Update of the TIDEL Trial. In BLOOD Vol. 114 (pp. 209-210). New Orleans, LA: AMER SOC HEMATOLOGY.
2009 Osborn, M. P., White, D. L., Saunders, V. A., Cambareri, B., Branford, S., Menelaou, A., . . . Hughes, T. P. (2009). Early Dose-Escalation in Chronic Myeloid Leukaemia Patients with Low Plasma Imatinib Levels Leads to Equivalent BCR-ABL Values and Drug Levels at 6 Months to Those with Optimal Drug Levels: First Analysis From the TIDEL II Trial of De-Novo Patients Treated with 600mg Imatinib.. In BLOOD Vol. 114 (pp. 465). New Orleans, LA: AMER SOC HEMATOLOGY.
2009 Soverini, S., Angelini, S., Turrini, E., Pane, F., Quarantelli, F., Hughes, T. P., . . . Martinelli, G. (2009). Association Between Imatinib (IM) Transporters and Metabolizing Enzymes Genotype and Response in Newly Diagnosed Chronic Myeloid Leukemia (CML) Patients (Pts) Is Influenced by Ethnicity. In BLOOD Vol. 114 (pp. 1271). New Orleans, LA: AMER SOC HEMATOLOGY.
2009 Engler, J. R., Frede, A., Saunders, V. A., Zannettino, A. C. W., White, D. L., & Hughes, T. P. (2009). OCT-1 Activity in CML CD34+Cells Is Not Predictive of Molecular Response to Imatinib Treatment in CP-CML Patients, Despite the Strong Predictive Value of MNC OCT-1 Activity. In BLOOD Vol. 114 (pp. 861). New Orleans, LA: AMER SOC HEMATOLOGY.
2008 Hiwase, D. K., White, D. L., Saunders, V. A., Melo, J. V., Kumar, S., & Hughes, T. P. (2008). Short-Term Intense Bcr-Abl Kinase Inhibition Is Adequate to Trigger Cell Death in CML Cell Lines but Not in CML-CD34+Cells Unless They Are Growth Factor Deprived. In BLOOD Vol. 112 (pp. 397). San Francisco, CA: AMER SOC HEMATOLOGY.
2008 Engler, J. R., Frede, A., Zannettino, A. C. W., White, D. L., & Hughes, T. P. (2008). Reduced Activity of the OCT-1 Protein in Primitive CML Cells: A Likely Determinant of Stem Cell Resistance in Imatinib Treated CML Patients. In BLOOD Vol. 112 (pp. 80). San Francisco, CA: AMER SOC HEMATOLOGY.
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2008 Esposito, N., Quarantelli, F., Luciano, L., Izzo, B., Peluso, A. L., Picardi, M., . . . Pane, F. (2008). The Expression of shp-1 and SHP-2: A Novel Powerful Predictor of Major Molecular Response (MMR) Achievement in Chronic Myeloid Leukemia Gleevec-Treated Patients Enrolled into the TOPS Clinical Trial. In BLOOD Vol. 112 (pp. 404). San Francisco, CA: AMER SOC HEMATOLOGY.
2008 Mullighan, C. G., Radtke, I., Zhang, J., Phillips, L. A., Su, X., Ma, J., . . . Downing, J. R. (2008). Genome-Wide Analysis of Genetic Alterations in Chronic Myelogenous Leukemia. In BLOOD Vol. 112 (pp. 397-398). San Francisco, CA: AMER SOC HEMATOLOGY.
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2008 White, D. L., Saunders, V. A., Kalebic, T., & Hughes, T. P. (2008). The IC50 Assay Is Predictive of Molecular Response, and Indicative of Optimal Dose in De-Novo CML Patients. In BLOOD Vol. 112 (pp. 405). San Francisco, CA: AMER SOC HEMATOLOGY.
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2008 White, D. L., Saunders, V. A., Dang, P., Frede, A., Eadie, L., Soverini, S., . . . Hughes, T. (2008). CML Patients with Low OCT-1 Activity Achieve Better Molecular Responses on High Dose Imatinib Than on Standard Dose. Those with High OCT-1 Activity Have Excellent Responses on Either Dose: A TOPS Correlative Study. In BLOOD Vol. 112 (pp. 1093-1094). San Francisco, CA: AMER SOC HEMATOLOGY.
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2008 White, D. L., Saunders, V. A., Dang, P., Frede, A., Eadie, L., Soverini, S., . . . Hughes, T. (2008). CML Patients with Low OCT-1 Activity Achieve Better Molecular Responses on High Dose Imatinib Than on Standard Dose. Those with High OCT-1 Activity Have Excellent Responses on Either Dose: A TOPS Correlative Study. In Blood Vol. 112 (pp. 3187). American Society of Hematology.
2007 Hiwase, D. K., White, D. L., Saunders, V. A., Dang, P., Venables, A., Eadie, L., . . . Hughes, T. P. (2007). In Contrast to Imatinib, OCT-1 Mediated Influx Has Minimal Impact on Cellular Uptake of Dasatinib in CML Patients at Diagnosis.. In Blood Vol. 110 (pp. 1937). American Society of Hematology.
2007 Hiwase, D. K., White, D. L., Saunders, V. A., Dang, P., Venables, A., Eadie, L., . . . Hughes, T. P. (2007). In contrast to imatinib, OCT-1 mediated influx has minimal impact on cellular uptake of dasatinib in CML patients at diagnosis. In BLOOD Vol. 110 (pp. 575A-576A). Atlanta, GA: AMER SOC HEMATOLOGY.
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2005 White, D. L., Saunders, V. A., Engler, J., Dang, P., Zannettino, A. C., Cambareri, A., . . . Hughes, T. P. (2005). Low baseline intrinsic sensitivity to imatinib (high IC50) in CML patients is due to reduced Oct-1 mediated influx. Intrinsic sensitivity to AMN107 does not correlate with that of imatinib and uptake of AMN107 is not Oct-1 mediated.. In BLOOD Vol. 106 (pp. 315A). Atlanta, GA: AMER SOC HEMATOLOGY.
2005 White, D. L., Saunders, V. A., Branford, S., Lynch, K., To, L. B., & Hughes, T. P. (2005). The in-vivo level of imatinib induced kinase inhibition achieved in de-novo CML patients during the first 28 days of therapy is a powerful predictor of molecular outcome.. In BLOOD Vol. 106 (pp. 132A). Atlanta, GA: AMER SOC HEMATOLOGY.
2004 White, D. L., Saunders, V. A., Branford, S., Lyons, B., & Hughes, T. P. (2004). The combination of intrinsic sensitivity to imatinib and Sokal prognostic score is strongly predictive of molecular response in newly diagnosed CML patients treated with imatinib.. In BLOOD Vol. 104 (pp. 288A-289A). San Diego, CA: AMER SOC HEMATOLOGY.

Conference Items

Year Citation
2022 Thomson, A., Rehn, J., Heatley, S., Eadie, L., McClure, B., Page, E., . . . White, D. (2022). Benchmarking the detection rate of IGH gene fusions in B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Australian Bioinformatics and Computational Biology Society (ABACBS) Conference.
2021 Heatley, S. L., Page, E. C., Eadie, L. N., McClure, B. J., Rehn, J., Yeung, D. T., . . . White, D. L. (2021). Modeling Relapsed, Refractory Acute Lymphoblastic Leukemia from a Child with Neurofibromatosis. Poster session presented at the meeting of BLOOD. Atlanta, GA: AMER SOC HEMATOLOGY.
2021 Eadie, L., Heatley, S., McClure, B., Rehn, J., Schutz, C., Breen, J., . . . White, D. (2021). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of 4th International T-ALL/T-NHL conference: T-ALL2020: Omics, genetics and therapy.
2021 McClure, B., Heatley, S., Grose, R., & White, D. (2021). Activation of the immune cell repertoire in B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of 12th Biennial Childhood Leukemia and Lymphoma Symposium (CLLS).
2021 Eadie, L., Heatley, S., McClure, B., Rehn, J., Schutz, C., Breen, J., . . . White, D. (2021). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of 12th Biennial Childhood Leukemia and Lymphoma Symposium (CLLS).
2021 Heatley, S., Rehn, J., Breen, J., Moore, A., Sutton, R., Osborn, M., & White, D. (2021). Using single cell mRNAseq to interrogate the genomic consequences of Ph-like acute lymphoblastic leukaemia in adolescents. Poster session presented at the meeting of 12th Biennial Childhood Leukemia and Lymphoma Symposium (CLLS).
2020 Poudel, G., Yeung, D., White, D., Hughes, T., & Pagani, I. (2020). Understanding the mechanisms of imatinib resistance in a Ph+ acute lymphoblastic leukaemia cell line. Poster session presented at the meeting of The 59th ASMR National Scientific Conference.
2020 Page, E., Heatley, S., Thomas, P., & White, D. (2020). HMGN1 is necessary for Down Syndrome leukaemic cell proliferation and cooperates with CRLF2 for leukaemic transformation. Poster session presented at the meeting of The 59th ASMR National Scientific Conference.
2020 Eadie, L., Heatley, S., McClure, B., Schutz, C., Breen, J., Hughes, T., . . . White, D. (2020). Next Generation Genomic Analyses Inform Druggable Targets In T-All Patients. Poster session presented at the meeting of Australian & New Zealand Children’s Haematology/Oncology Group.
2020 McClure, B., Heatley, S., Grose, R., Yeung, D., & White, D. (2020). Activation of the immune cell repertoire in B-cell acute lymphoblastic leukaemia.. Poster session presented at the meeting of Australian & New Zealand Children’s Haematology/Oncology Group.
2020 Page, E., Heatley, S., Thomas, P., & White, D. (2020). Inducible Knockout of HMGN1 in an In Vivo xenograft Model Reduces Down Syndrome Leukemic Burden and Increases Survival Outcomes. Poster session presented at the meeting of 62nd ASH ANNUAL MEETING AND EXPOSITION.
2020 Downes, C. E. J., McClure, B. J., Rehn, J., Breen, J., Bruning, J. B., Yeung, D. T., & White, D. L. (2020). Acquired Mutations within the JAK2 Kinase Domain Confer Resistance to JAK Inhibitors in an <i>in Vitro</i> model of a High-Risk Acute Lymphoblastic Leukemia. Poster session presented at the meeting of BLOOD. ELECTR NETWORK: AMER SOC HEMATOLOGY.
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2020 Eadie, L. N., Rehn, J., Heatley, S. L., McClure, B. J., Schutz, C. S., Breen, J., . . . White, D. L. (2020). Next Generation Genomic Analyses in T-ALL Patients Identify Recurrent and Novel Genomic Abnormalities. Poster session presented at the meeting of BLOOD. ELECTR NETWORK: AMER SOC HEMATOLOGY.
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2020 Tavakoli, P., Eadie, L. N., Heatley, S. L., Bruning, J. B., & White, D. L. (2020). Persistent Activation of JAK/STAT Signaling Plays an Important Role in<i>in Vitro</i>Jaki Resistance in <i>TYK2</i>-rearranged B-Cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of BLOOD. ELECTR NETWORK: AMER SOC HEMATOLOGY.
2020 Tavakoli, P. S., Eadie, L. N., Heatley, S. L., Yeung, D. T., & White, D. L. (2020). The MYB-TYK2 gene fusion induces B-cell acute lymphoblastic leukaemia in in vitro and in vivo models and can be effectively targeted by the dual SYK/JAK inhibitor, cerdulatinib. Poster session presented at the meeting of 25th Congress of The European Hematology Association. Frankfurt, Germany (virtual meeting).
2020 Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L. N., Schutz, C. E., . . . White, D. L. (2020). Targeted pseudo-alignment technique for rapid and accurate identification of disease-causing variants in acute lymphoblastic leukaemia. Poster session presented at the meeting of 14th Annual Florey Postgraduate Conference. Adelaide, South Australia.
2020 Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L. N., Schutz, C. E., . . . White, D. L. (2020). Pseudo-alignment technique for accurate detection of disease-causing variants in acute lymphoblastic leukaemia. Poster session presented at the meeting of Australian Bioinformatics and Computational Biology Society (ABACBS) 2020 National Conference. Canberra, ACT.
2020 Forgione, M. O., McClure, B. J., Eadie, L. N., & White, D. L. (2020). CD44 and its ligand osteopontin are upregulated specifically in KMT2A-AFF1 T-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of ASMR Annual Scientific Meeting. Adelaide, South Australia.
2020 Tavakoli, P. S., Eadie, L. N., Heatley, S. L., Yeung, D. T., & White, D. L. (2020). Vorinostat treatment demonstrated efficacy against MYB-TYK2 altered B-cell acute lymphoblastic leukaemia in in vitro and in vivo models. Poster session presented at the meeting of ASMR Annual Scientific Meeting. Adelaide, South Australia.
2020 Tavakoli, P. S., Eadie, L. N., Heatley, S. L., Bruning, J. B., & White, D. L. (2020). Persistent activation of JAK/STAT signaling plays an important role in in vitro Jaki resistance in TYK2-rearranged B-Cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of 62nd Annual Meeting of the American Society of Hematology. San Diego, California (virtual conference).
2019 Page, E. C., Heatley, S. L., Yeung, D. T., Thomas, P. Q., & White, D. L. (2019). A Novel Role for <i>HMGN1</i> in Down Syndrome Acute Lymphoblastic Leukemia. Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY.
2019 Yeung, D. T., Shanmuganathan, N., Grigg, A., Cunningham, I., Shortt, J., Rowling, P., . . . Hughes, T. P. (2019). Combination of Nilotinib and Pegylated Interferon Alfa-2B Results in High Rates of MR4.5 at 24 Months - Primary Analysis of the ALLG CML 11 Pinnacle Study. Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY.
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2019 Yeung, D. T., Grigg, A., Shanmuganathan, N., Solterbeck, A. C., White, D. L., Branford, S., . . . Hughes, T. P. (2019). Pro-Active Dasatinib Dose Reduction Based on Trough Levels May Minimise Toxicity and Preserve Efficacy - Interim Analysis of the ALLG CML 12 Direct Study. Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY.
2019 El Khawanky, N., Hughes, A., Yu, W., Taromi, S., Clarson, J., Lopez, A. F., . . . Zeiser, R. (2019). Azacytidine Sensitizes AML Cells for Effective Elimination By CD123 CAR T-Cells. Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY.
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2019 Cario, G., Leoni, V., Conter, V., Attarbaschi, A., Zaliova, M., Sramkova, L., . . . Biondi, A. (2019). Poor Prognosis in Children with ABL-Class Fusion Positive B-Cell Acute Lymphoblastic Leukemia Treated According to AIEOP-BFM Protocols. Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY.
2019 Tavakoli, P. S., Eadie, L., Heatley, S. L., & White, D. L. (2019). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of Australian and New Zealand Children’s Haematology/Oncology Group (ANZCHOG) Scientific Meeting 2019. Christchurch, New Zealand.
2019 Eadie, L., Heatley, S. L., McClure, B. J., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploration of the Genomic Diversity in T-ALL Patients Using mRNA Sequencing. Poster session presented at the meeting of 1st European Society of Haematology (ESH) Translational Conference on ALL. Berlin, Germany.
2019 Eadie, L., Heatley, S. L., McClure, B. J., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploration of the Genomic Diversity in T-ALL Patients Using mRNA Sequencing. Poster session presented at the meeting of ASMR Annual Scientific Meeting. Adelaide, South Australia.
2019 Rehn, J. A., Breen, J., Heatley, S. L., McClure, B. J., Eadie, L., Schutz, C. E., . . . White, D. L. (2019). Investigating “alignment-free” computational techniques for the accurate identification of Acute Lymphoblastic Leukaemia (ALL) gene fusion events. Poster session presented at the meeting of SAHMRI Annual Scientific Meeting. Adelaide, South Australia.
2019 Heatley, S. L., McClure, B. J., Eadie, L. N., Rehn, J. A., Breen, J., Hughes, T. P., . . . White, D. L. (2019). Exploring the genomic diversity of AYA and adult high-risk B-ALL cases by mRNA sequencing. Poster session presented at the meeting of SAHMRI Annual Scientific Meeting. Adelaide, South Australia.
2019
2018 Downes, C., McClure, B., & White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk B-ALL JAK2-fusion. Poster session presented at the meeting of Childhood Leukaemia and Lymphoma Symposium. Helsinki, Finland.
2018 Asari, K., Leclercq, T., Srihari, S., Fitter, S., Yeung, D., Hughes, T., . . . White, D. L. (2018). in vitro modelling of Ph-like ALL uncovers novel genomic alterations associated with TKI-resistance as a consequence of targeted therapy. Poster session presented at the meeting of Childhood Leukaemia and Lymphoma Symposium. Helsinki, Finland.
2018 Heatley, S. L., Mayne, B. T., McClure, B. J., Kok, C., Sadras, T., Dang, P., . . . White, D. L. (2018). Exploring the genomic diversity of AYA and adult high-risk B-ALL cases by mRNA sequencing. Poster session presented at the meeting of 23rd Congress of European Hematology Association. Stockholm, Sweden.
2018 Downes, C. E., McClure, B. J., Heatley, S. L., Yeung, D. T., & White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk B-ALL JAK2-fusion. Poster session presented at the meeting of NDLR.
2018 Heatley, S. L., McClure, B. J., Kok, C., Sadras, T., Dang, P., Galbraith, K., . . . White, D. L. (2018). Exploring the genomic diversity of adult and AYA cases with high-risk B-ALL by mRNA sequencing. Poster session presented at the meeting of NDLR.
2018 Pagani, I. S., Kok, C., Saunders, V., Schwarer, A., Hughes, T. P., White, D. L., & Ross, D. M. (2018). Association of mitochondrial DNA (mtDNA) mutations at diagnosis with treatment response in chronic myeloid leukaemia (CML) patients. Poster session presented at the meeting of NDLR.
2018 Eadie, L. N., Mullighan, C., & White, D. L. (2018). Mutations to the transcription factor MYB alter cellular localization and decrease degradation likely enhancing oncogenicity in patients with T-cell ALL. Poster session presented at the meeting of NDLR.
2018 Lu, L., Kok, C., Saunders, V., Nievergall, E., White, D. L., & Hughes, T. P. (2018). TGF-α predicts TKI treated CML patients who fail to achieve early molecular response. Poster session presented at the meeting of NDLR.
2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of APG Student Awards.
2018 Page, E. C., Heatley, S. L., Thomas, P., & White, D. L. (2018). Precision medicine approaches may be the future for CRLF2 rearranged Down Syndrome Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of ASMR.
2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification of ruxolitinib resistance mutations in Pro-B cells driven by a high-risk JAK2 fusion in B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of ASMR.
2018 Tavakoli Shiraz, P., Eadie, L. N., Heatley, S. L., & White, D. L. (2018). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of ASMR.
2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and Characterisation of Ruxolitinib Resistant Mutations in JAK2-rearranged B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of AGTA.
2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification of mutations that cause ruxolitinib resistance in Pro-B cells driven by a high-risk B-ALL JAK2-fusion.. Poster session presented at the meeting of ANZCHOG.
2018 Tavakoli Shiraz, P., Eadie, L. N., Heatley, S. L., & White, D. L. (2018). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of SAHMRI Scientific Seminar.
2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of SAHMRI Scientific Seminar.
2018 Tavakoli Shiraz, P., Eadie, L. N., Heatley, S. L., & White, D. L. (2018). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of 12th Annual Florey postgraduate Conference.
2018 Downes, C. E., McClure, B. J., Mayne, B. T., Bruning, J. B., Heatley, S. L., Kok, C., . . . White, D. L. (2018). Identification and computational modelling of ruxolitinib resistant mutations in JAK2-rearranged B-cell acute lymphoblastic leukaemia. Poster session presented at the meeting of EMBL Australia Postgraduate Symposium.
2018 Tavakoli Shiraz, P., Eadie, L. N., Heatley, S. L., & White, D. L. (2018). The dual SYK/JAK inhibitor cerdulatinib demonstrates in vitro efficacy against a novel MYB-TYK2 fusion protein in acute lymphoblastic leukaemia cells. Poster session presented at the meeting of EMBL Australia Postgraduate Symposium.
2018 Osborn, M., Dalla-Pozza, L., Trahair, T., Sutton, R., White, D. L., Fleming, S., & Greenwood, M. (2018). The Australasian Leukaemia and Lymphoma Group (ALLG) ALL09 Trial: A Phase II Study of Blinatumomab as Induction Therapy in Adolescent and Young Adult (AYA) Acute Lymphoblastic Leukaemia (ALL).. Poster session presented at the meeting of Global AYA Cancer Congress.
2017 El-Khawanky, N., Hughes, A., Yu, W., Clarson, J., Lopez, A. F., Brown, M., . . . Yong, A. (2017). CD123 Chimeric Antigen Receptor T-cells in Chronic and Acute Myeloid Leukaemia: pre-clinical in vitro studies. Poster session presented at the meeting of HAA.
2017 El-Khawanky, N., Hughes, T. P., Clarson, J., Yu, W., White, D. L., & Yong, A. (2017). Anti-CD123 Chimeric Antigen Receptor (CAR) T-cells in Chronic and Acute Myeloid Leukaemia: pre-clinical in vitro studies. Poster session presented at the meeting of ASMR.
2017 McClure, B. J., Heatley, S. L., Kok, C., Sadras, T., An, J., Quek, K., . . . White, D. L. (2017). EP300-ZNF384 is a recurrent fusion gene with distinct gene expression in adolescent/young adult pre-B-ALL patients. Poster session presented at the meeting of ANZCHOG.
2017 Heatley, S. L., Sadras, T., Kok, C., Nievergall, E., Quek, K., Dang, P., . . . White, D. L. (2017). High Prevalence of Relapse in Australian Children with Ph-like Acute Lymphoblastic Leukemia Despite Risk-Adapted Treatment. Poster session presented at the meeting of ANZCHOG.
2017 Asari, K., Sadras, T., Srihari, S., Fitter, S., An, J., Zannettino, A. C., . . . White, D. L. (2017). in vitro Modelling of Ph-like ALL Fusions Uncovers Novel Kinase-domain Mutations as a Mode of TKI-resistance and Potential Consequence of Targeted TKI Therapy. Poster session presented at the meeting of ANZCHOG.
2017 McClure, B. J., Heatley, S. L., Sadras, T., Sutton, R., & White, D. L. (2017). EP300-ZNF384 is a recurrent fusion gene with distinct gene expression in adolescent/young adult Australian pre-B-acute lymphoblastic leukaemia. Poster session presented at the meeting of IBFM.
2017 Ross, D. M., Pagani, I. S., Shanmuganathan, N., Seymour, J. F., Mills, A., Filshie, R., . . . Hughes, T. P. (2017). Long-Term Follow-up of the ALLG CML8 Twister Study of Treatment-Free Remission (TFR) in Patients with Chronic Myeloid Leukemia (CML). Poster session presented at the meeting of 59th ASH Annual Meeting & Exposition.
2017 Hughes, A., Clarson, J., White, D. L., Yeung, D., Hughes, T. P., & Yong, A. S. M. (2017). Nilotinib/Interferon-α Combination Rapidly Enhances Leukaemia-Associated Antigen Specific Cytotoxic T-Lymphocyte Immune Responses, Limits Natural Killer Cell Maturation and Triggers B Cell Remodelling. Poster session presented at the meeting of BLOOD. Atlanta, GA: AMER SOC HEMATOLOGY.
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2017 Yeung, D., Grigg, A., Shanmuganathan, N., Cunningham, I., Shortt, J., Rowling, P., . . . Hughes, T. P. (2017). Nilotinib in Combination with Pegylated Interferon Alfa-2b for CP-CML Leads to High Molecular Response Rates: Interim Results of the Pinnacle Study. Poster session presented at the meeting of BLOOD. Atlanta, GA: AMER SOC HEMATOLOGY.
2017 Pagani, I. S., Dang, P., Kommers, I. O., Goyne, J., Saunders, V. A., Prime, J. A., . . . Ross, D. M. (2017). COMPARISON OF GENOMIC DNA AND REVERSE TRANSCRIPTASE Q-PCR FOR THE MONITORING OF FIRST-LINE IMATINIB TREATMENT: AN ALLG CML9 SUB-STUDY. Poster session presented at the meeting of HAEMATOLOGICA. Madrid, SPAIN: FERRATA STORTI FOUNDATION.
2017 Downes, C. E., McClure, B. M., Heatley, S. H., Sadras, T. S., Hughes, T. H., Kok, C. K., . . . White, D. W. (2017). Identification and cloning of a novel GOLGA4-JAK2 fusion from an adult patient with B-cell Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Poster session presented at the ASMR SA Scientific Meeting. Adelaide.
2017
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2016 Kok, C. H., Watkins, D., Wang, J., Saunders, V., Goyne, J., Pagani, I., . . . White, D. (2016). HIGH GENE EXPRESSION OF HIST1H2AG AND HIST1H4A REDUCES IMATINIB UPTAKE INTO CML CELLS AND PREDICTS POOR RESPONSE TO FRONTLINE IMATINIB THERAPY. Poster session presented at the meeting of HAEMATOLOGICA. Copenhagen, DENMARK: FERRATA STORTI FOUNDATION.
2016 Heatley, S., Sadras, T., kok, C., Venn, N., Revesz, T., Osborn, M., . . . White, D. L. (2016). Australian Children with Ph-like ALL enrolled to ANZCHOG ALL8 had a high prevalence of relapse despite risk adapted treatment. Poster session presented at the meeting of CLS SCIENTIFIC PROGRAMME, Refractory Leukemia and Miscellaneous. Athens.
2016 Lock, R., Dollai, S., Sia, K., Daly, R., Rafferty, M., White, D. L., . . . Revesz, T. (2016). Quantitative Phosphotyrosine Profiling of patient derived xenografts identifies therapeutic targets in paediatric ALL. Poster session presented at the meeting of .. Athens.
2016 Sadras, T., Heatley, S., Dang, P., Kok, C., Quek, K., Nievergall, E., . . . White, D. L. (2016). A nine-gene signature defines 2 groups of CRLF2 rearranged B-ALL patients with distinctive genetic features. Poster session presented at the meeting of .. Athens.
2016 Pagani, I. S., Kok, C., Saunders, V., Goyne, J., McLean, J., Vanderhoek, M., . . . Ross, D. (2016). The genomic landscape of mitochondrial DNA mutations in chronic myeloid leukaemia. Poster session presented at the meeting of .. Barcelona, Spain.
2016 Eadie, L., Saunders, V., Branford, S., Hughes, T., & White, D. (2016). Resistance mechanisms of the new allosteric inhibitor ABL001. Poster session presented at the meeting of ,. Houtson, USA.
2016 Eadie, L., Goyne, J., Hughes, T., & White, D. (2016). ABCC6 plays a significant role in the transport of nilotinib in both cells lines and primary patient cells, and may contribute to resistance. Poster session presented at the meeting of ,. Houston, USA.
2016 Saunders, V. A., Wang, J., Lu, L., Eadie, L. N., McLean, J. A., Goyne, J. M., . . . Hughes, T. P. (2016). A Low Concentration of ABL001 Potentiates <i>In Vitro</i> TKI-Induced Bcr-Abl Kinase Inhibition in CML Cells. Poster session presented at the meeting of BLOOD. San Diego, CA: AMER SOC HEMATOLOGY.
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2016 Eadie, L. N., Goyne, J., Hughes, T., & White, D. L. (2016). The ABCC6 Transporter Plays a Significant Role in the Efflux of Nilotinib and Dasatinib, and May Contribute to Tyrosine Kinase Inhibitor Resistance. Poster session presented at the meeting of .. San Diego, USA: AMER SOC HEMATOLOGY.
2016
2016 Eadie, L., Saunders, V., Leclercq, T., Branford, S., White, D. L., & Hughes, T. (2016). Abl001 Is Susceptible To Resistance Mediated By Overexpression Of Drug Transporters Abcb1 and Abcg2. Poster session presented at the meeting of .. Noosa, QLD.
2016 Sadras, T., Heatley, S., Kok, C., Quek, K., Dang, P., Nievergall, E., . . . White, D. L. (2016). CRLF2 rearranged B-ALL cases with a Ph-like gene signature are enriched for JAK2 mutations. Poster session presented at the meeting of .. Noosa, QLD.
2016 Lu, L., Saunders, V., Kok, C., Leclercq, T., Hughes, T., & White, D. (2016). Modelling ponatinib resistance in BCR-ABL1+ cell lines: implications for ponatinib therapy. Poster session presented at the meeting of New Directions in Leukaemia Research 2016. Noosa, QLD.
2016 McClure, B., Heatley, S., Sadras, T., Nievergall, E., Kok, C., Dang, P., . . . White, D. L. (2016). Identification of a significantly high prevalence of relapse in Australian children with Ph-like ALL. Poster session presented at the meeting of .. Noosa, QLD.
2016 Asari, K., Heatley, S., Leclercq, T., Fitter, S., Zannettino, A., Hughes, T., & White, D. L. (2016). In vitro Modelling of Therapeutic Resistance to Elucidate Mechanisms of TKI-Resistant High-Risk ALL. Poster session presented at the meeting of .. Noosa, QLD.
2016 Pagani, I., Kok, C., Saunders, V., Goyne, J., McLean, J., Vanderhoek, M., . . . White, D. L. (2016). Do mitochondrial mutations in chronic myeloid leukaemia identify a pre-leukemic clone?. Poster session presented at the meeting of .. Noosa, QLD.
2016 Eadie, L., Dang, P., Saunders, V., Hughes, T., & White, D. L. (2016). The clinical significance of early imatinib induced ABCB1 overexpression in chronic phase CML patients treated sequentially with imatinib and nilotinib: A TIDEL II sub-study. Poster session presented at the meeting of ,. Adelaide, SA.
2016 White, D. L., McClure, B., Heatley, S., Sadras, T., Quek, K., & Hughes, T. (2016). Investigation of the transforming capacity of a recently identified EP300-ZNF384 fusion gene in adult acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA.
2016 Leow, B., Eadie, L. N., Leclercq, T., & White, D. L. (2016). Drug resistance in CML: heterogeneity, selection, and clonal architecture. Poster session presented at the meeting of Poster Session. Adelaide, SA.
2016 Asari, K., Heatley, S., Leclercq, T., Fitter, S., Kok, C. H., Zannettino, A., . . . White, D. L. (2016). Investigating Modes of Therapeutic Resistance via In Vitro Modelling of TKI-resistant High-Risk Philadelphia-chromosome-positive and Philadelphia-chromosome-like Acute Lymphoblastic Leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA.
2016 Galbraith, K., Sadras, T., McClure, B., Heatley, S., & White, D. L. (2016). Identification of novel therapeutic targets in CRLF2 rearranged acute lymphoblastic leukaemia. Poster session presented at the meeting of Poster Session. Adelaide, SA.
2016 Watts, S., Saunders, V., Wee, A., Kutyna, M., White, D. L., Hughes, T., & Hiwase, D. (2016). Understanding the mechanism of secondary resistance to Azacitidine in Myelodysplastic syndromes using the cell-line model MOLM-13. Poster session presented at the meeting of Poster Session. Adelaide, SA.
2016 Kok, C. H., Watkins, D., Wang, J., Saunders, V., Goyne, J., Pagani, I. S., . . . White, D. L. (2016). High Gene Expression of hist1h2ag and hist1h4a Reduces Imatinib Uptake into CML Cells and Predicts Poor Response to Frontline Imatinib Therapy. Poster session presented at the meeting of Poster Session. Melbourne, VIC.
2016 Heatley, S., Sadras, T., McClure, B., Kok, C. H., Dang, P., Nievergall, E., . . . White, D. L. (2016). The Incidence of Ph-like Acute Lymphoblastic Leukaemia (ALL) Increases with Age and is Characterised by Poor Outcome. Poster session presented at the meeting of Poster Session. Melbourne, VIC.
2016 Pagani, I. S., Kok, C. H., Wang, J., Saunders, V., Van der Hoek, M., Heatley, S., . . . Ross, D. (2016). Mitochondrial DNA Mutations at Diagnosis are Linked to Response in TKI treated Chronic Myeloid Leukaemia Patients. Poster session presented at the meeting of Poster Session. Melbourne, VIC.
2016 Watts, S., Wee, A., Saunders, V., Kutyna, M., White, D. L., Hughes, T., & Hiwase, D. (2016). Determining Mechanisms of Resistance to Azacitidine (Aza) in Myelodysplastic (MDS) Syndromes and Acute Myeloid Leukaemia (AML) using an in-vitro model. Poster session presented at the meeting of Poster Session. Melbourne, VIC.
2016 Lu, L., Saunders, V., Kok, C. H., Leclercq, T., Hughes, T., & White, D. L. (2016). Modelling Ponatinib Resistance In BCR-ABL1+ Cell Lines: Implications For Ponatinib Therapy. Poster session presented at the meeting of Poster Session. Adelaide, SA.
2016 Hughes, A., Clarson, J., White, D. L., Ross, D. M., Hughes, T. P., & Yong, A. S. (2016). Enhanced Natural Killer and Cytotoxic T Lymphocyte Responses, with Decreased Monocytic Myeloid Derived Suppressor Cells May Promote Treatment Free Remission in Chronic Myeloid Leukaemia Patients Following Tyrosine Kinase Inhibitor Cessation. Poster session presented at the meeting of BLOOD. San Diego, CA: AMER SOC HEMATOLOGY.
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2015 Zaliova, M., Moorman, A., Cazzaniga, G., Stanulla, M., Harvey, R., Roberts, K., . . . Zuna, J. (2015). Characterization of Leukemias with ETV6-ABL1 Fusion. Poster session presented at the meeting of BLOOD. Orlando, FL: AMER SOC HEMATOLOGY.
2014 Lu, L., Saunders, V., Kok, C. H., Leclercq, T., Hughes, T. P., & White, D. L. (2014). Modeling Ponatinib Resistance in <i>BCR-ABL1</i>+ Cell Lines: Implications for Ponatinib Resistance in TKI-Resistant and TKI-naive Patients. Poster session presented at the meeting of BLOOD. AMER SOC HEMATOLOGY.
2014 Yeung, D. T., Vidovic, L., Tang, C., White, D. L., Branford, S., Hughes, T. P., & Yong, A. S. M. (2014). KIR2DL5B Genotype Independently Predicts Poor Outcomes in CML-CP Patients Switched to Nilotinib after Suboptimal Responses to Imatinib and May Refine Prognosis in Patients with EMR Failure. Poster session presented at the meeting of BLOOD. San Francisco, CA: AMER SOC HEMATOLOGY.
2014
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2014 Parker, W. T., Phillis, S. R., Yeung, D. T., Lawrence, D., Schreiber, A., Wang, P., . . . Branford, S. (2014). Detection of BCR-ABL1 Compound and Polyclonal Mutants in Chronic Myeloid Leukemia Patients Using a Novel Next Generation Sequencing Approach That Minimises PCR and Sequencing Errors. Poster session presented at the meeting of BLOOD. San Francisco, CA: AMER SOC HEMATOLOGY.
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2013 White, D. L., Schafranek, L., Nievergall, E., Powell, J. A., Hiwase, D., Leclercq, T., & Hughes, T. (2013). STAT5 is a critical component of the time-dependent sensitivity of CML cells to TKI treatment in a Bcr-Abl-dependent, but JAK2-independent manner.. Poster session presented at the meeting of American Society of Haematology. New Orleans, USA.
2013 White, D., Saunders, V., Eadie, L., David, Y., & Hughes, T. P. (2013). The Depth Of <i>In Vivo</i> Kinase Inhibition Achieved Over The First Month Of Nilotinib Therapy Predicts For Subsequent Molecular Response, and Is Closely Related To Nilotinib Plasma Levels. Poster session presented at the meeting of BLOOD. New Orleans, LA: AMER SOC HEMATOLOGY.
WoS1
2013 Wang, J., Kok, C. H., D'Andrea, R. J., Hughes, T. P., & White, D. L. (2013). Role Of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Its Ligands In The Regulation Of Functional OCT-1 Activity In CML Cells. Poster session presented at the meeting of BLOOD. New Orleans, LA: AMER SOC HEMATOLOGY.
2013 White, D. L., Eadie, L., & Hughes, T. (2013). Increasing Expression of the Efflux Transporter ABCB1 may Predispose CML Cells to Overt TKI Resistance.. Poster session presented at the meeting of American Society of Haematology. New Orleans, USA.
2012 White, D. L., Saunders, V., Yeung, D., Grigg, A., & Hughes, T. (2012). Early Molecular Response to Imatinib in CP-CML Patients: The Significance of Early Dose Intensity and OCT-1 Activity in Responders and Efficacy of Dose Escalation and Switch to Nilotinib in Non-Responders.. Poster session presented at the meeting of American Society of Haematology. Atlanta, USA.
2012
2012 Yeung, D. T., Osborn, M. P., White, D. L., Branford, S., Kornhauser, M., Slader, C., . . . Hughes, T. P. (2012). Early Switch to Nilotinib Does Not Overcome the Adverse Outcome for CML Patients Failing to Achieve Early Molecular Response On Imatinib, Despite Excellent Overall Outcomes in the TIDEL II Trial. Poster session presented at the meeting of BLOOD. Atlanta, GA: AMER SOC HEMATOLOGY.
WoS8
2012 Nievergall, E., White, D. L., Yong, A. S. M., Ramshaw, H. S., Busfield, S. J., Vairo, G., . . . Hiwase, D. K. (2012). Effective Elimination of CML Progenitor and Stem Cells Through Combination of α-CD123 Antibody-Dependent Cell-Mediated Cytotoxicity and Tyrosine Kinase Inhibitor Treatment. Poster session presented at the meeting of BLOOD. GA, Atlanta: AMER SOC HEMATOLOGY.
2012 Schafranek, L., Nievergall, E., Powell, J. A., Hiwase, D. K., White, D. L., & Hughes, T. P. (2012). Commitment of CML Cells to Apoptotic Cell Death Depends On the Length of Exposure to Das and the Level of STAT5 Activity. Poster session presented at the meeting of BLOOD. Atlanta, GA: AMER SOC HEMATOLOGY.
WoS3
Year Citation
2017 Downes, C. E. (2017). Cloning, Signalling Characterisation and JAK2 Inhibitor-Resistance of Two JAK2 Fusions in High-Risk B-ALL. (Undergraduate Dissertation).

Peer Reviewed Research Funding

I have been successful in securing competitive research funding (Approx $30million).

International Competitive Schemes LLS (CML. 2009 and 2016) and the Hughes Foundation/USC Parker Institute (ALL 2015, 2016) NHMRC (2007 (CML),2009(CML), 2012(CML), 2012 (ALL), 2013(CML),and 2014(CML), Leukaemia Foundation of Australia (LFA) (2008 2012 (CML) and 2013 (ALL)), Cancer Council of SA (2011 (CML) and 2012 (ALL) and Channel 7 2015 (ALL). NHMRC TCR in genomics now (AGHA)(ALL $25 million). A significant outcome of the work of my group has been the successful translation into clinical practice. In excess of $5.5 million in Pharmaceutical funding over the last 10 years has been secured.

International Peer Reviewed Competitive Schemes

 
2016 Developing a bioassay-based algorithm for selecting frontline therapy in chronic myeloid leukemia Timothy Hughes, CIB:Deborah L White, Gerald Radich, David Yeung, Chung Kok and John Reynolds   $US600,000.00  
2015 Identification of mechanisms of drug resistance in paediatric models of Ph-like ALL treated with targeted therapies

CIB- Charles Mullighan

$US450,000.00  
2009 The role of OCT-1 Activity enhancers in improving the response of patients with low OCT-1 activity to Imatinib $US600,000.00  

National Peer Reviewed Competitive Schemes (Other than NHMRC)

2019 Precision Medicine in Acute Lymphoblastic Leukaemia Laura Eadie $250,000.00
2019 Acute Lymphoblastic Leukaemia: Understanding the factors that determine response to new immune-based therapies. David Lynn and Gerraint Rogers $100,000.00
2019 Reducing the toxicity associated with agonistic antibody cancer immunotherapies by targeting the gut microbiota Steven Blake, David Lynn and $50,000.00
2019 Precision Medicine in Acute Lymphobastic Leukaemia $600,000.00 
2018 INFRASTRUCTURE: Australian Cancer Research Foundation Centre for Integrated Cancer Systems Biology (ACRFCICSB) CIs: Hughes, Zannettino, White, Proud, Wesselingh, Lynn, Butler, Gronthos, Tilley, Price, Worthley, Bulone $2,500,000.00 
2018 INFRASTRUCTURE: A Bioinformatician for the Joint SAHMRI/AHMRI Bioinformatics Core $234,000.00 
2018 The role of the gut microbiota in the efficacy and toxicity of agonistic antibody cancer immunotherapies Lynn D., Blake S. & White D $22,890.00 
2017 Improving outcomes for high risk ALL treated with new therapies and transplant. Rosemary Sutton, Deborah White, Toby Trahair, Peter Shaw  $600,000.00 
2017 Rapid Identification of High Risk Subtypes & Targeted Treatments for Children with Acute Lymphoblastic Leukaemia Toby Trahair, Rosemary Sutton, Glenn Marshall, Draga Barbaric, Luciano Dalla Pozza, Deborah White $200,000.00 
2017 INFRASTRUCTURE: Adelaide Flow Cytometry Facility. Robertson, McColl, Zannettino, Tyreman, Thompson, Mitchell, Brown, McKinnon, Hayball, Cowin, Makridis, White $480,000.00 
2017 INFRASTRUCTURE: Zero Childhood Cancer $20,000,000.00

(Received $1,479,303.00)
2017 Better Outcomes for Child & Adolescent ALL Project. Toby Trahair, Marion Mateos, Glenn Marshall, David Ziegler, Rosemary Sutton, Rishi Kotecha, Siobhan Cross, Deborah White $200,000.00
2016 Improving outcomes for children with leukaemia through molecular targeted therapies $800,000.00 
2016 High-Risk T cell ALL Laura Eadie and Deborah White $75,000.00
2016 Single cell genomics in high-risk ALL Susan Heatley and Deborah White  $176,000.00 
2016 INFRASTRUCTURE: Transforming research into improved heatlh for patients with Leukaemia $90,000.00
2015 Developing a robust screening tool to identify children with high risk “Ph-like” Acute Lymphoblastic Leukaemia (ALL) that will lead to improved outcomes through the use of targeted therapies Susan Heatley, Deborah White, Charles Mullighan $75,000.00
2013 INFRASTRUCTURE: Cancer Imaging and Therapeutics Facility CIs: Mullighan, Hughes, White, Zannettino, Gronthos, Keefe, Monro, Roder, Tilley, Price. $1,800,000.00 
2013 Childhood Ph-like ALL: Improving Diagnostic Screening and Therapeutic Rationale $100,000.00 
2012 INFRASTRUCTURE: Establishing the SA Biospecimen Respository $980,000.00 
2012 Assessing the cause and drug susceptibility of Adult high-risk ALL $80,000.00 
2012 Characterisation of immune responses in CML patients on nilotinib and interferon alpha Yong, A, Hughes, T and White DL $100,000.00 
2012 Developing a gene signature to predict the optimal front line kinase inhibitor for CP-CML patients $99,254.00 
2011 Developing a patient specific approach to the treatment of CP-CML with tyrosine kinase inhibitors: investigating the factors which determine response to nilotinib and dasatinib $92,508.00 

NHMRC Schemes (peer reviewed) (>$13 million)

2019 Setting a new Paradigm for Diagnosis and Therapeutic Triage in ALL using Functional Genomics $483,404.00 
2017  Chronic myeloid leukaemia: changing the treatment paradigm CI’s: Hughes, Ross, Branford, White, Yong, and Reynolds $1,162,778.08
2016 Genomics Translation:

Preparing Australia for Genomic Medicine: A Proposal by the Australian Genomics Health Alliance (AGHA)
$25,000,000.00

(Received $1,250,000.00)
2015 Aberrant Signalling in Leukaemia CI’s: A. Lopez, T Hughes, M Parket AI: White, D $6,669,345.00
2014 Determining the prerequisites for the achievement of treatment-free remission in chronic myeloid leukaemia to facilitate the development of new therapeutic approaches with curative intent CIA: Timothy Hughes, CIB: Deborah White, CIC: Susan Branford, CID:David Ross, CIE:Agnes Yong $1,400,000.00 
2013 Screening and targeting newly discovered genetic lesions in poor risk adult and childhood ALL $718,892.85 
2012 Characterisation of a New Poor-Risk Sub-Category of Chronic Phase Chronic Myeloid Leukaemia $588,675.00 
2012 Rational development of a bioassay-based treatment algorithm for kinase inhibitor therapy in CML CIA Timothy Hughes, CIB Deborah White, CIC John Rasko $509,880.00 
2009 Development and assessment of novel assays to predict response to second-line TKI therapy in imatinib resistant CML CIA:Timothy Hughes, CIB: Junia Melo, CIC:Susan Branford, CID: Deborah L White $485,000.00

Industry Funding - Granted (>$5.5 million)

2015 Correlative Science Proposal Associated with the DIRECT study $598,000.00 
2015 Correlative Science Proposal Associated with the REGALLIA Clinical Registry $902,965.00 
2015 Correlative Science Proposal Associated with the LENI David Ross, Timothy Hughes, Deborah Whiteand Agnes Yong $440,000.00 
2014 Correlative Science Proposal Associated with the ENESTswift clinical trial $500,000.00 
2014 Correlative Science Proposal Associated with the PINNACLE clinical trial $675,000.00 
2012 Correlative Science Proposal Associated with the ALL06 clinical trial $94,560.00 
2011 Provision of imatinib OCT-1 Activity testing for newly diagnosed CML patients $155,925.00 
2011 Correlative Science Proposal Associated with the ENESTxtnd clinical trial $698,255.68 
2011 Correlative Science Associated with TIDELII Clinical Trial - expansion of patient numbers $65,971.00 
2011 Seed Funding: Investigating the Prevalence of Druggable Novel Gene Fusion, Detectable by Phospho-Flow Analysis in High Risk Adult B-ALL $20,880.00 
2010 RESIST Registry Timothy Hughes and Deborah White $920,000.00 
2010 Correlative Science Associated with TIDELII Clinical Trial Cohort 2 $659,707.91 
2009 Correlative Science Proposal

Associated with the Ph+ ALL- Dasatinib clinical trial.
$154,919.00 

Local Schemes- Granted

2017 Evaluate role of cellular influx and efflux pumps in Azacitidine Devendra Hiwase, Sophie Watts, Verity Saunders, Timothy Hughes, Deborah White and Amilia Wee $25,000.00 
2017 Functional effects of mitochondrial mutations in CML David Ross and Deborah White, Ilaria Pagani and Timothy Hughes $25,000.00 
2016 Do mitochondrial mutations in chronic myeloid leukaemia identify a pre-leukaemic clone David Ross and Deborah White $25,000.00
2016 Identification of mechanisms of drug resistance in models of Ph-like ALL treated with targeted therapies David Yeung, Sue Heatley, Tessa Sadras, Tim Hughes, Deborah White $25,000.00
2015 Digital PCR for BCR-ABL DNA in chronic myeloid leukaemia David Ross and Deborah White $30,000.00
2014 Mitochondrial mutations in chronic myeloid leukaemia. David Ross and Deborah White $30,000.00

Undergraduate Lectures

Guest Lecturer CML Biology 3 rd Year Health and Biotech, University of SA

Guest Lecturer 3 rd Year Pharmacology

Guest Lecturer 3 rd Year Biomedical Science 

Guest lecture series Final Year Advanced Biomedical Science + associated tutorials

Project Mentor to third year MBBS students; Research Project Design: ALL

Current Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2024 Principal Supervisor Clinical Transcriptomic Sequencing Analysis Workflows for Acute Lymphoblastic Leukaemia (ALL): Improving Subtype Characterisation in Complex Fusion Events Doctor of Philosophy Doctorate Full Time
2024 Principal Supervisor Identifying Predictors of CNS involvement in Acute Lymphoblastic Leukaemia Doctor of Philosophy Doctorate Full Time Mr Luke Jacob Quinlan
2023 Co-Supervisor Modelling co-occurring mutations in T-cell Acute Lymphoblastic Leukaemia to enhance treatment options and maximise the power of next generation sequencing Doctor of Philosophy Doctorate Full Time
2023 Co-Supervisor Discovery of novel metabolic targets against lDH1-mutant intrahepatic cholangiocarcinoma Doctor of Philosophy Doctorate Full Time Mrs Tasnova Tasnim Nova
2023 Principal Supervisor Interrogating the DUX4 rearranged subtype of B cell Acute Lymphoblastic Leukaemia Doctor of Philosophy Doctorate Full Time Mr Thomas Oliver McGovern
2023 Principal Supervisor Exploring the impact of the gut microbiota on the clinical scenario in Acute Lymphoblastic Leukaemia patients Doctor of Philosophy Doctorate Full Time
2022 Principal Supervisor Characterisation of a novel fusion, genetic contributors and effectiveness of drug combinations in Ph-like Acute Lymphoblastic Leukaemia and the clinical relevance. Doctor of Philosophy Doctorate Full Time Jane Frances Thompson
2022 Co-Supervisor A humanized monocyte model of TET2 mutated clonal hematopoiesis for noel target discovery Doctor of Philosophy Doctorate Full Time Miss Maha Kamel
2021 Principal Supervisor Investigation of current, innovative treatments and the roles of secondary genomic lesions in BCR-ABL1 positive leukaemias Doctor of Philosophy Doctorate Full Time Mr Elias Lagonik

Past Higher Degree by Research Supervision (University of Adelaide)

Date Role Research Topic Program Degree Type Student Load Student Name
2019 - 2023 Co-Supervisor Bioinformatic approaches to variant detection and subtype classification in acute lymphoblastic leukaemia Doctor of Philosophy Doctorate Full Time Miss Jacqueline Ann Rehn
2019 - 2022 Principal Supervisor Characterising KMT2A and MLLT10 Rearranged Acute Lymphoblastic Leukaemia Doctor of Philosophy Doctorate Full Time Miss Michelle Olivia Forgione
2018 - 2022 Principal Supervisor Precision Medicine Approaches for JAK2-Rearranged Acute Lymphoblastic Leukaemia: The Efficacy of Targeted Therapies and Molecular Mechanisms of Drug Resistance Doctor of Philosophy Doctorate Full Time Miss Charlotte Emma-Jeane Downes
2018 - 2021 Principal Supervisor Exploring the cooperation and targetability of CRLF2 and HMGN1 in Down Syndrome Acute Lymphoblastic Leukaemia Doctor of Philosophy Doctorate Full Time
2017 - 2021 Principal Supervisor Characterising the novel MYB-TYK2 fusion gene in high-risk acute lymphoblastic leukaemia: oncogenic potential, effective therapeutic strategies and In vitro modelling of drug resistance mechanisms Doctor of Philosophy Doctorate Full Time Miss Paniz Tavakoli Shirazi
2016 - 2021 Principal Supervisor The Combined Treatment Efficacy of Anti-CD123 CAR T cells with Azacitidine for the Treatment of Acute Myeloid Leukaemia. Doctor of Philosophy under a Jointly-awarded Degree Agreement with Doctorate Full Time Miss Nadia El-Khawanky
2015 - 2019 Principal Supervisor Multiple Molecular Mechanisms Contribute Towards In Vitro Resistance to Tyrosine Kinase Inhibitors In Chronic Myeloid Leukaemia Doctor of Philosophy Doctorate Full Time Mr Benjamin Chia Sing Leow
2014 - 2018 Principal Supervisor In vitro Modelling of High-risk ALL Fusions Uncovers Genomic Alterations and Non-canonical Signalling Pathways as a Mode of TKI-Resistance - Implications for Targeted Therapy Doctor of Philosophy Doctorate Full Time Miss Kartini Asari
2012 - 2014 Co-Supervisor The role of cytokines in governing the expansion of the T315I mutation in Chronic myeloid leukaemia Master of Philosophy (Medical Science) Master Full Time Dr Oi-Lin Lee
2012 - 2016 Principal Supervisor In Vitro Investigation of Intracellular Ponatinib Transport and Modeling Ponatinib Resistence in BCR-ABL1+ Cell Lines: Implications for Therapeutic Strategies Doctor of Philosophy Doctorate Full Time Miss Liu Lu
2012 - 2018 Co-Supervisor Personalized Medicine Support System for Chronic Myeloid Leukaemia Patients Doctor of Philosophy Doctorate Full Time Mrs Haneen Reda M Banjar
2010 - 2014 Co-Supervisor Assessment of Critical Survival Mechanisms Exploited by BCR-ABL1+ Cells to Evade Tyrosine Kinase Inhibitor-Induced Death; Determination of Novel Therapeutic Targets in Chronic Myeloid Leukaemia Doctor of Philosophy Doctorate Full Time Miss Lisa Schafranek
2010 - 2014 Principal Supervisor Defining CP-CML patient subsets associated with poor imatinib uptake and response Doctor of Philosophy Doctorate Full Time Mr Dale Benjamin Watkins
2009 - 2013 Co-Supervisor Nilotinib Efflux and Resistance Development: The Effects of Combination and Concomitant Therapies on the Transport and Efficacy of Nilotinib Doctor of Philosophy Doctorate Full Time
2008 - 2013 Co-Supervisor Investigating Drugs that Enhance Imatinib Uptake and Factors which Contribute to the Functional Activity of OCT-1 in CML Cells Doctor of Philosophy Doctorate Full Time Miss Jueqiong Wang
2008 - 2010 Co-Supervisor Evaluation of Anti-proliferative and Pro-apoptotic Effects of Tyrosine Kinase Inhibitors on CML-CD34+ Cells Doctor of Philosophy Doctorate Full Time APrf Devendra Hiwase
2008 - 2011 Co-Supervisor Cell Lineage, Cell Maturity and BCR-ABL: Factors Which Influence Imatinib Uptake in Chronic Myeloid Leukaemia Doctor of Philosophy Doctorate Full Time Ms Jane Engler
2008 - 2012 Co-Supervisor TKI Resistance in CML Cell Lines: Investigating Resistance Pathways Doctor of Philosophy Doctorate Full Time Mrs Carine Tang

Board Memberships

Date Role Board name Institution name Country
2023 - ongoing Member South Australian Genomics Consortium (SAGC) Advisory Board SAGC Australia
2023 - ongoing Director Board of Directors Australian and New Zealand Children's Oncology Group (ANZCHOG) ANZCHOG Australia
2023 - ongoing Director Board of Directors Australasian Leukaemia Lymphomas Group (ALLG) ALLG Australia
2016 - ongoing Member Nuclear Fuel Cycle Royal Commission Consultation and Response Advisory (CARA) Board - -

Committee Memberships

Date Role Committee Institution Country
2017 - ongoing Advisory Board Member Australian and New Zealand Children's Hematology/ Oncology Group Australia
2016 - ongoing Member Scientific Symposium Committee South Australian Health and Medical Research Institutesa Australia
2016 - ongoing Founder Statewide Cancer Translational Research Group - Australia
2016 - ongoing Founder SA Translational Cancer Research Group Meetings - Australia
2016 - ongoing Chair Post Graduate Student Forum Basil Hetzel Institute Research Day Australia
2016 - ongoing Chair SAHMRI Imaging Workshop South Australia Health and Medical Research Institute -
2016 - ongoing Chair Women in Health Science Session National Directions in Leukemia Research Australia
2016 - ongoing Chair ALL Stream of Australian Genomics Health Care Alliance (AGHA) - -
2016 - ongoing Member Scientific Committee for the New Directions in Leukaemia Research Conference - -
2016 - ongoing Member Australian Genomics Health Care Alliance (AHGA) Executive - -
2016 - ongoing Chair ALL Stream of the Australian Genomics Health Care Alliance (AHGA) - -
2016 - ongoing Chair SAHMRI Genomics Executive Committee - -
2015 - ongoing Member Women in Science Executive Committee - -
2015 - ongoing Member NHMRC Women in Health Science Faculty - -
2015 - ongoing Member National Women in Health Science Faculty NHMRC Australia
2015 - ongoing Chair Ross Wishart Memorial Award Australian Society for Medical Research Australia
2015 - ongoing Chair CML and Myelproliferative Neoplasms HAA -
2015 - ongoing Member US Ambassadors Round Table on Scientific Innovation - -
2015 - ongoing Member American Association for Cancer Research United States
2014 - ongoing Member International Chronic Myeloid Leukemia Foundation (iCMLf) Australia
2014 - ongoing Member Scientific Committee for the New Directions in Leukaemia Research Conference - -
2014 - ongoing Member SA Translational Haematology Research Group Meetings - -
2014 - ongoing Chair CML and Myeloproliferative Neoplasm Session New Directions in Leukemia Research Australia
2014 - ongoing Chair Women in Science session New Directions in Leukemia Research Australia
2014 - ongoing Chair Women in Science session New Directions in Leukemia Research Australia
2014 - ongoing Chair Young Investigator session New Directions in Leukemia Research Australia
2014 - 2016 Member SAHMRI post graduate student Committee - -
2014 - 2015 Advisory Board Member (Malignant Haematology) HAA Organising Committee - Australia
2013 - ongoing Member Biosciences Pillar Committee - -
2013 - ongoing Member Executive Management Committee - -
2013 - ongoing Member Research Executive Committee - -
2013 - ongoing Member BMS Advisory Board on Molecular Monitoring and Drug level Testing - -
2013 - 2015 Founder Haematology Statewide Translational Research Group - -
2013 - ongoing Member International Children's Oncology Group -
2012 - ongoing Member New Directions in Leukemia Research Conference - -
2012 - ongoing Chair Myeloid Leukaemia Session New Directions in Leukemia Research Australia
2012 - ongoing Chair Leukaemia Foundation Early Career Scientists Session New Directions in Leukemia Research -
2012 - ongoing Chair Bioscience Pillar SA Comprehensive Cancer Consortium (SACCC) - -
2012 - ongoing Member NHMRC Research Translational faculty - -
2012 - ongoing Member SAHMRI Bioscience Pillar Committee - -
2012 - ongoing Chair ALL Stream of the Australian Genomics Health Care Alliance (AHGA) - Australia
2012 - ongoing Member Research Translational faculty NHMRC Australia
2012 - ongoing Member Bioscience Pillar Committee South Australian Health and Medical Research Institute Australia
2012 - ongoing Member • Member of the South Australian Cancer Collaborative (SACCC) Executive Committee - -
2008 - ongoing Member Global Advisory Board Blood Level Testing and Mutational Analysis Novartis -
2008 - ongoing Member European Haematology Association - -
2008 - ongoing Member American Society of Haematology - United States
2008 - ongoing Member Haematology Association of Australia and New Zealand - Australia
2008 - ongoing Member Australian Leukemia and Lymphoma Group Australia
2000 - ongoing Member The Australasian Leukaemia & Lymphoma Group Scientific Committee - -

Memberships

Date Role Membership Country
2016 - ongoing Member Franklin Women -
2015 - ongoing Member American Association for Cancer Research -
2014 - ongoing Member International CML Foundation -
2013 - ongoing Member International Children’s Oncology Group (COG) -
2010 - ongoing Member Australian Leukaemia and Lymphoma Group: Laboratory Scientific Committee (only non-­clinician invited) -
2008 - ongoing Member Haematology Association of Australia and New Zealand -
2008 - ongoing Member Australian Leukaemia and Lymphoma Group (ALLG) -
2008 - ongoing Member European Haematology Association -
2008 - ongoing Member American Society of Haematology -

Consulting/Advisories

Date Institution Department Organisation Type Country
2016 - ongoing Department of Premier and Cabinet DPC and CARA Legislative and political Australia
2015 - ongoing Sigma Aldrich: Science Next Collaborative - - -
2013 - ongoing BMS Advisory Board on Molecular Monitoring and Drug level Testing - - -
2008 - ongoing Novartis Global Advisory Board Blood Level Testing and Mutational Analysis - - -

Editorial Boards

Date Role Editorial Board Name Institution Country
2016 - ongoing Associate Editor Journal of Blood Research & Hematologic Diseases -
  • Position: Director, Cancer Program and Deputy Theme
  • Phone: 0881284302
  • Email: [email protected]
  • Campus: North Terrace
  • Building: SAHMRI, floor 5
  • Org Unit: Adelaide Medical School

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The Adelaide Business School offers research degrees at both the masters and doctorate levels: the Master of Philosophy (MPhil) and the Doctor of Philosophy (PhD). 

Our programs are benchmarked with other Go8 universities, and our international collaborations in research (UNESCO and OECD reports, TIMSS and PISA studies) introduce broader issues into our theory and practice of education.

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Make a meaningful impact on society as you explore your passion and create new knowledge. Our supportive and welcoming networks will set you up for the future.

Janin Hetzen

Janin Hetzen

"I came across a scholarship opportunity at the University of Adelaide, I knew I had to apply. The fact that I am writing this here shows that I did get rewarded for 'going for it'. The scholarship was the first and probably most important reason as to why I chose to study at the University of Adelaide. I found great supervisors who shared my research vision and excitement -  they supported me in my decisions and guided me."

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  1. Doctor of Philosophy | Degree Finder - The University of Adelaide

    Doctor of Philosophy. The Doctor of Philosophy is the University’s flagship research award and is the standard pre-requisite for a career in research or academia. The PhD involves three – four years of research for a full-time candidate or the equivalent in half-time candidature.

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    Professor White is the Director of the Cancer Program and Deputy Precision Medicine Theme Leader at the South Australian Health and Medical Research Institute (SAHMRI) in Adelaide. She is a NHMRC RD Wright Biomedical Research Fellow, a Beat Cancer Prinicpal Research Fellow and Senior Principal Research Fellow with SAHMRI.

  9. Higher Degrees By Research | Adelaide Business School ...

    The Adelaide Business School offers research degrees at both the masters and doctorate levels: the Master of Philosophy (MPhil) and the Doctor of Philosophy (PhD). Our programs are benchmarked with other Go8 universities, and our international collaborations in research (UNESCO and OECD reports, TIMSS and PISA studies) introduce broader issues ...

  10. Higher Degree Research - University of Adelaide

    IIT offers a research degree: Doctorate of Philosophy (PhD). PhD students from a variety of disciplines, including trade, development studies, economics, business and law, have studied for higher degrees within the IIT.