Although hypothesis tests have been the basis of modern science since the middle of the 20th century, they have been plagued by misconceptions from the outset; this has led to what has been described as a crisis in science in the last few years: some journals have gone so far as to ban p -value s outright. 6 This is not because of any flaw in the concept of a p -value, but because of a lack of understanding of what they mean.
Possibly the most pervasive misunderstanding is the belief that the p- value is the chance that the null hypothesis is true, or that the p- value represents the frequency with which you will be wrong if you reject the null hypothesis (i.e. claim to have found a difference). This interpretation has frequently made it into the literature, and is a very easy trap to fall into when discussing hypothesis tests. To avoid this, it is important to remember that the p- value is telling us something about our sample , not about the null hypothesis. Put in simple terms, we would like to know the probability that the null hypothesis is true, given our data. The p- value tells us the probability of getting these data if the null hypothesis were true, which is not the same thing. This fallacy is referred to as ‘flipping the conditional’; the probability of an outcome under certain conditions is not the same as the probability of those conditions given that the outcome has happened.
A useful example is to imagine a magic trick in which you select a card from a normal deck of 52 cards, and the performer reveals your chosen card in a surprising manner. If the performer were relying purely on chance, this would only happen on average once in every 52 attempts. On the basis of this, we conclude that it is unlikely that the magician is simply relying on chance. Although simple, we have just performed an entire hypothesis test. We have declared a null hypothesis (the performer was relying on chance); we have even calculated a p -value (1 in 52, ≈0.02); and on the basis of this low p- value we have rejected our null hypothesis. We would, however, be wrong to suggest that there is a probability of 0.02 that the performer is relying on chance—that is not what our figure of 0.02 is telling us.
To explore this further we can create two populations, and watch what happens when we use simulation to take repeated samples to compare these populations. Computers allow us to do this repeatedly, and to see what p- value s are generated (see Supplementary online material). 7 Fig 1 illustrates the results of 100,000 simulated t -tests, generated in two set of circumstances. In Fig 1 a , we have a situation in which there is a difference between the two populations. The p- value s cluster below the 0.05 cut-off, although there is a small proportion with p >0.05. Interestingly, the proportion of comparisons where p <0.05 is 0.8 or 80%, which is the power of the study (the sample size was specifically calculated to give a power of 80%).
The p- value s generated when 100,000 t -tests are used to compare two samples taken from defined populations. ( a ) The populations have a difference and the p- value s are mostly significant. ( b ) The samples were taken from the same population (i.e. the null hypothesis is true) and the p- value s are distributed uniformly.
Figure 1 b depicts the situation where repeated samples are taken from the same parent population (i.e. the null hypothesis is true). Somewhat surprisingly, all p- value s occur with equal frequency, with p <0.05 occurring exactly 5% of the time. Thus, when the null hypothesis is true, a type I error will occur with a frequency equal to the alpha significance cut-off.
Figure 1 highlights the underlying problem: when presented with a p -value <0.05, is it possible with no further information, to determine whether you are looking at something from Fig 1 a or Fig 1 b ?
Finally, it cannot be stressed enough that although hypothesis testing identifies whether or not a difference is likely, it is up to us as clinicians to decide whether or not a statistically significant difference is also significant clinically.
Hypothesis testing: what next?
As mentioned above, some have suggested moving away from p -values, but it is not entirely clear what we should use instead. Some sources have advocated focussing more on effect size; however, without a measure of significance we have merely returned to our original problem: how do we know that our difference is not just a result of sampling variation?
One solution is to use Bayesian statistics. Up until very recently, these techniques have been considered both too difficult and not sufficiently rigorous. However, recent advances in computing have led to the development of Bayesian equivalents of a number of standard hypothesis tests. 8 These generate a ‘Bayes Factor’ (BF), which tells us how more (or less) likely the alternative hypothesis is after our experiment. A BF of 1.0 indicates that the likelihood of the alternate hypothesis has not changed. A BF of 10 indicates that the alternate hypothesis is 10 times more likely than we originally thought. A number of classifications for BF exist; greater than 10 can be considered ‘strong evidence’, while BF greater than 100 can be classed as ‘decisive’.
Figures such as the BF can be quoted in conjunction with the traditional p- value, but it remains to be seen whether they will become mainstream.
Declaration of interest
The author declares that they have no conflict of interest.
The associated MCQs (to support CME/CPD activity) will be accessible at www.bjaed.org/cme/home by subscribers to BJA Education .
Jason Walker FRCA FRSS BSc (Hons) Math Stat is a consultant anaesthetist at Ysbyty Gwynedd Hospital, Bangor, Wales, and an honorary senior lecturer at Bangor University. He is vice chair of his local research ethics committee, and an examiner for the Primary FRCA.
Matrix codes: 1A03, 2A04, 3J03
Supplementary data to this article can be found online at https://doi.org/10.1016/j.bjae.2019.03.006 .
Supplementary material
The following is the Supplementary data to this article:
Hypothesis Testing for Means & Proportions
Lisa Sullivan, PhD
Professor of Biostatistics
Boston University School of Public Health
Introduction
This is the first of three modules that will addresses the second area of statistical inference, which is hypothesis testing, in which a specific statement or hypothesis is generated about a population parameter, and sample statistics are used to assess the likelihood that the hypothesis is true. The hypothesis is based on available information and the investigator's belief about the population parameters. The process of hypothesis testing involves setting up two competing hypotheses, the null hypothesis and the alternate hypothesis. One selects a random sample (or multiple samples when there are more comparison groups), computes summary statistics and then assesses the likelihood that the sample data support the research or alternative hypothesis. Similar to estimation, the process of hypothesis testing is based on probability theory and the Central Limit Theorem.
This module will focus on hypothesis testing for means and proportions. The next two modules in this series will address analysis of variance and chi-squared tests.
Learning Objectives
After completing this module, the student will be able to:
Define null and research hypothesis, test statistic, level of significance and decision rule
Distinguish between Type I and Type II errors and discuss the implications of each
Explain the difference between one and two sided tests of hypothesis
Estimate and interpret p-values
Explain the relationship between confidence interval estimates and p-values in drawing inferences
Differentiate hypothesis testing procedures based on type of outcome variable and number of sample
Introduction to Hypothesis Testing
Techniques for hypothesis testing .
The techniques for hypothesis testing depend on
the type of outcome variable being analyzed (continuous, dichotomous, discrete)
the number of comparison groups in the investigation
whether the comparison groups are independent (i.e., physically separate such as men versus women) or dependent (i.e., matched or paired such as pre- and post-assessments on the same participants).
In estimation we focused explicitly on techniques for one and two samples and discussed estimation for a specific parameter (e.g., the mean or proportion of a population), for differences (e.g., difference in means, the risk difference) and ratios (e.g., the relative risk and odds ratio). Here we will focus on procedures for one and two samples when the outcome is either continuous (and we focus on means) or dichotomous (and we focus on proportions).
General Approach: A Simple Example
The Centers for Disease Control (CDC) reported on trends in weight, height and body mass index from the 1960's through 2002. 1 The general trend was that Americans were much heavier and slightly taller in 2002 as compared to 1960; both men and women gained approximately 24 pounds, on average, between 1960 and 2002. In 2002, the mean weight for men was reported at 191 pounds. Suppose that an investigator hypothesizes that weights are even higher in 2006 (i.e., that the trend continued over the subsequent 4 years). The research hypothesis is that the mean weight in men in 2006 is more than 191 pounds. The null hypothesis is that there is no change in weight, and therefore the mean weight is still 191 pounds in 2006.
Null Hypothesis
H : μ= 191 (no change)
Research Hypothesis
H : μ> 191 (investigator's belief)
In order to test the hypotheses, we select a random sample of American males in 2006 and measure their weights. Suppose we have resources available to recruit n=100 men into our sample. We weigh each participant and compute summary statistics on the sample data. Suppose in the sample we determine the following:
Do the sample data support the null or research hypothesis? The sample mean of 197.1 is numerically higher than 191. However, is this difference more than would be expected by chance? In hypothesis testing, we assume that the null hypothesis holds until proven otherwise. We therefore need to determine the likelihood of observing a sample mean of 197.1 or higher when the true population mean is 191 (i.e., if the null hypothesis is true or under the null hypothesis). We can compute this probability using the Central Limit Theorem. Specifically,
(Notice that we use the sample standard deviation in computing the Z score. This is generally an appropriate substitution as long as the sample size is large, n > 30. Thus, there is less than a 1% probability of observing a sample mean as large as 197.1 when the true population mean is 191. Do you think that the null hypothesis is likely true? Based on how unlikely it is to observe a sample mean of 197.1 under the null hypothesis (i.e., <1% probability), we might infer, from our data, that the null hypothesis is probably not true.
Suppose that the sample data had turned out differently. Suppose that we instead observed the following in 2006:
How likely it is to observe a sample mean of 192.1 or higher when the true population mean is 191 (i.e., if the null hypothesis is true)? We can again compute this probability using the Central Limit Theorem. Specifically,
There is a 33.4% probability of observing a sample mean as large as 192.1 when the true population mean is 191. Do you think that the null hypothesis is likely true?
Neither of the sample means that we obtained allows us to know with certainty whether the null hypothesis is true or not. However, our computations suggest that, if the null hypothesis were true, the probability of observing a sample mean >197.1 is less than 1%. In contrast, if the null hypothesis were true, the probability of observing a sample mean >192.1 is about 33%. We can't know whether the null hypothesis is true, but the sample that provided a mean value of 197.1 provides much stronger evidence in favor of rejecting the null hypothesis, than the sample that provided a mean value of 192.1. Note that this does not mean that a sample mean of 192.1 indicates that the null hypothesis is true; it just doesn't provide compelling evidence to reject it.
In essence, hypothesis testing is a procedure to compute a probability that reflects the strength of the evidence (based on a given sample) for rejecting the null hypothesis. In hypothesis testing, we determine a threshold or cut-off point (called the critical value) to decide when to believe the null hypothesis and when to believe the research hypothesis. It is important to note that it is possible to observe any sample mean when the true population mean is true (in this example equal to 191), but some sample means are very unlikely. Based on the two samples above it would seem reasonable to believe the research hypothesis when x̄ = 197.1, but to believe the null hypothesis when x̄ =192.1. What we need is a threshold value such that if x̄ is above that threshold then we believe that H 1 is true and if x̄ is below that threshold then we believe that H 0 is true. The difficulty in determining a threshold for x̄ is that it depends on the scale of measurement. In this example, the threshold, sometimes called the critical value, might be 195 (i.e., if the sample mean is 195 or more then we believe that H 1 is true and if the sample mean is less than 195 then we believe that H 0 is true). Suppose we are interested in assessing an increase in blood pressure over time, the critical value will be different because blood pressures are measured in millimeters of mercury (mmHg) as opposed to in pounds. In the following we will explain how the critical value is determined and how we handle the issue of scale.
First, to address the issue of scale in determining the critical value, we convert our sample data (in particular the sample mean) into a Z score. We know from the module on probability that the center of the Z distribution is zero and extreme values are those that exceed 2 or fall below -2. Z scores above 2 and below -2 represent approximately 5% of all Z values. If the observed sample mean is close to the mean specified in H 0 (here m =191), then Z will be close to zero. If the observed sample mean is much larger than the mean specified in H 0 , then Z will be large.
In hypothesis testing, we select a critical value from the Z distribution. This is done by first determining what is called the level of significance, denoted α ("alpha"). What we are doing here is drawing a line at extreme values. The level of significance is the probability that we reject the null hypothesis (in favor of the alternative) when it is actually true and is also called the Type I error rate.
α = Level of significance = P(Type I error) = P(Reject H 0 | H 0 is true).
Because α is a probability, it ranges between 0 and 1. The most commonly used value in the medical literature for α is 0.05, or 5%. Thus, if an investigator selects α=0.05, then they are allowing a 5% probability of incorrectly rejecting the null hypothesis in favor of the alternative when the null is in fact true. Depending on the circumstances, one might choose to use a level of significance of 1% or 10%. For example, if an investigator wanted to reject the null only if there were even stronger evidence than that ensured with α=0.05, they could choose a =0.01as their level of significance. The typical values for α are 0.01, 0.05 and 0.10, with α=0.05 the most commonly used value.
Suppose in our weight study we select α=0.05. We need to determine the value of Z that holds 5% of the values above it (see below).
The critical value of Z for α =0.05 is Z = 1.645 (i.e., 5% of the distribution is above Z=1.645). With this value we can set up what is called our decision rule for the test. The rule is to reject H 0 if the Z score is 1.645 or more.
With the first sample we have
Because 2.38 > 1.645, we reject the null hypothesis. (The same conclusion can be drawn by comparing the 0.0087 probability of observing a sample mean as extreme as 197.1 to the level of significance of 0.05. If the observed probability is smaller than the level of significance we reject H 0 ). Because the Z score exceeds the critical value, we conclude that the mean weight for men in 2006 is more than 191 pounds, the value reported in 2002. If we observed the second sample (i.e., sample mean =192.1), we would not be able to reject the null hypothesis because the Z score is 0.43 which is not in the rejection region (i.e., the region in the tail end of the curve above 1.645). With the second sample we do not have sufficient evidence (because we set our level of significance at 5%) to conclude that weights have increased. Again, the same conclusion can be reached by comparing probabilities. The probability of observing a sample mean as extreme as 192.1 is 33.4% which is not below our 5% level of significance.
Hypothesis Testing: Upper-, Lower, and Two Tailed Tests
The procedure for hypothesis testing is based on the ideas described above. Specifically, we set up competing hypotheses, select a random sample from the population of interest and compute summary statistics. We then determine whether the sample data supports the null or alternative hypotheses. The procedure can be broken down into the following five steps.
Step 1. Set up hypotheses and select the level of significance α.
H 0 : Null hypothesis (no change, no difference);
H 1 : Research hypothesis (investigator's belief); α =0.05
Upper-tailed, Lower-tailed, Two-tailed Tests
The research or alternative hypothesis can take one of three forms. An investigator might believe that the parameter has increased, decreased or changed. For example, an investigator might hypothesize:
: μ > μ , where μ is the comparator or null value (e.g., μ =191 in our example about weight in men in 2006) and an increase is hypothesized - this type of test is called an ; : μ < μ , where a decrease is hypothesized and this is called a ; or : μ ≠ μ where a difference is hypothesized and this is called a .
The exact form of the research hypothesis depends on the investigator's belief about the parameter of interest and whether it has possibly increased, decreased or is different from the null value. The research hypothesis is set up by the investigator before any data are collected.
Step 2. Select the appropriate test statistic.
The test statistic is a single number that summarizes the sample information. An example of a test statistic is the Z statistic computed as follows:
When the sample size is small, we will use t statistics (just as we did when constructing confidence intervals for small samples). As we present each scenario, alternative test statistics are provided along with conditions for their appropriate use.
Step 3. Set up decision rule.
The decision rule is a statement that tells under what circumstances to reject the null hypothesis. The decision rule is based on specific values of the test statistic (e.g., reject H 0 if Z > 1.645). The decision rule for a specific test depends on 3 factors: the research or alternative hypothesis, the test statistic and the level of significance. Each is discussed below.
The decision rule depends on whether an upper-tailed, lower-tailed, or two-tailed test is proposed. In an upper-tailed test the decision rule has investigators reject H 0 if the test statistic is larger than the critical value. In a lower-tailed test the decision rule has investigators reject H 0 if the test statistic is smaller than the critical value. In a two-tailed test the decision rule has investigators reject H 0 if the test statistic is extreme, either larger than an upper critical value or smaller than a lower critical value.
The exact form of the test statistic is also important in determining the decision rule. If the test statistic follows the standard normal distribution (Z), then the decision rule will be based on the standard normal distribution. If the test statistic follows the t distribution, then the decision rule will be based on the t distribution. The appropriate critical value will be selected from the t distribution again depending on the specific alternative hypothesis and the level of significance.
The third factor is the level of significance. The level of significance which is selected in Step 1 (e.g., α =0.05) dictates the critical value. For example, in an upper tailed Z test, if α =0.05 then the critical value is Z=1.645.
The following figures illustrate the rejection regions defined by the decision rule for upper-, lower- and two-tailed Z tests with α=0.05. Notice that the rejection regions are in the upper, lower and both tails of the curves, respectively. The decision rules are written below each figure.
Rejection Region for Upper-Tailed Z Test (H : μ > μ ) with α=0.05
The decision rule is: Reject H if Z 1.645.
α
Z
0.10
1.282
0.05
1.645
0.025
1.960
0.010
2.326
0.005
2.576
0.001
3.090
0.0001
3.719
Rejection Region for Lower-Tailed Z Test (H 1 : μ < μ 0 ) with α =0.05
The decision rule is: Reject H 0 if Z < 1.645.
a
Z
0.10
-1.282
0.05
-1.645
0.025
-1.960
0.010
-2.326
0.005
-2.576
0.001
-3.090
0.0001
-3.719
Rejection Region for Two-Tailed Z Test (H 1 : μ ≠ μ 0 ) with α =0.05
The decision rule is: Reject H 0 if Z < -1.960 or if Z > 1.960.
0.20
1.282
0.10
1.645
0.05
1.960
0.010
2.576
0.001
3.291
0.0001
3.819
The complete table of critical values of Z for upper, lower and two-tailed tests can be found in the table of Z values to the right in "Other Resources."
Critical values of t for upper, lower and two-tailed tests can be found in the table of t values in "Other Resources."
Step 4. Compute the test statistic.
Here we compute the test statistic by substituting the observed sample data into the test statistic identified in Step 2.
Step 5. Conclusion.
The final conclusion is made by comparing the test statistic (which is a summary of the information observed in the sample) to the decision rule. The final conclusion will be either to reject the null hypothesis (because the sample data are very unlikely if the null hypothesis is true) or not to reject the null hypothesis (because the sample data are not very unlikely).
If the null hypothesis is rejected, then an exact significance level is computed to describe the likelihood of observing the sample data assuming that the null hypothesis is true. The exact level of significance is called the p-value and it will be less than the chosen level of significance if we reject H 0 .
Statistical computing packages provide exact p-values as part of their standard output for hypothesis tests. In fact, when using a statistical computing package, the steps outlined about can be abbreviated. The hypotheses (step 1) should always be set up in advance of any analysis and the significance criterion should also be determined (e.g., α =0.05). Statistical computing packages will produce the test statistic (usually reporting the test statistic as t) and a p-value. The investigator can then determine statistical significance using the following: If p < α then reject H 0 .
Step 1. Set up hypotheses and determine level of significance
H 0 : μ = 191 H 1 : μ > 191 α =0.05
The research hypothesis is that weights have increased, and therefore an upper tailed test is used.
Step 2. Select the appropriate test statistic.
Because the sample size is large (n > 30) the appropriate test statistic is
Step 3. Set up decision rule.
In this example, we are performing an upper tailed test (H 1 : μ> 191), with a Z test statistic and selected α =0.05. Reject H 0 if Z > 1.645.
We now substitute the sample data into the formula for the test statistic identified in Step 2.
We reject H 0 because 2.38 > 1.645. We have statistically significant evidence at a =0.05, to show that the mean weight in men in 2006 is more than 191 pounds. Because we rejected the null hypothesis, we now approximate the p-value which is the likelihood of observing the sample data if the null hypothesis is true. An alternative definition of the p-value is the smallest level of significance where we can still reject H 0 . In this example, we observed Z=2.38 and for α=0.05, the critical value was 1.645. Because 2.38 exceeded 1.645 we rejected H 0 . In our conclusion we reported a statistically significant increase in mean weight at a 5% level of significance. Using the table of critical values for upper tailed tests, we can approximate the p-value. If we select α=0.025, the critical value is 1.96, and we still reject H 0 because 2.38 > 1.960. If we select α=0.010 the critical value is 2.326, and we still reject H 0 because 2.38 > 2.326. However, if we select α=0.005, the critical value is 2.576, and we cannot reject H 0 because 2.38 < 2.576. Therefore, the smallest α where we still reject H 0 is 0.010. This is the p-value. A statistical computing package would produce a more precise p-value which would be in between 0.005 and 0.010. Here we are approximating the p-value and would report p < 0.010.
Type I and Type II Errors
In all tests of hypothesis, there are two types of errors that can be committed. The first is called a Type I error and refers to the situation where we incorrectly reject H 0 when in fact it is true. This is also called a false positive result (as we incorrectly conclude that the research hypothesis is true when in fact it is not). When we run a test of hypothesis and decide to reject H 0 (e.g., because the test statistic exceeds the critical value in an upper tailed test) then either we make a correct decision because the research hypothesis is true or we commit a Type I error. The different conclusions are summarized in the table below. Note that we will never know whether the null hypothesis is really true or false (i.e., we will never know which row of the following table reflects reality).
Table - Conclusions in Test of Hypothesis
is True
Correct Decision
Type I Error
is False
Type II Error
Correct Decision
In the first step of the hypothesis test, we select a level of significance, α, and α= P(Type I error). Because we purposely select a small value for α, we control the probability of committing a Type I error. For example, if we select α=0.05, and our test tells us to reject H 0 , then there is a 5% probability that we commit a Type I error. Most investigators are very comfortable with this and are confident when rejecting H 0 that the research hypothesis is true (as it is the more likely scenario when we reject H 0 ).
When we run a test of hypothesis and decide not to reject H 0 (e.g., because the test statistic is below the critical value in an upper tailed test) then either we make a correct decision because the null hypothesis is true or we commit a Type II error. Beta (β) represents the probability of a Type II error and is defined as follows: β=P(Type II error) = P(Do not Reject H 0 | H 0 is false). Unfortunately, we cannot choose β to be small (e.g., 0.05) to control the probability of committing a Type II error because β depends on several factors including the sample size, α, and the research hypothesis. When we do not reject H 0 , it may be very likely that we are committing a Type II error (i.e., failing to reject H 0 when in fact it is false). Therefore, when tests are run and the null hypothesis is not rejected we often make a weak concluding statement allowing for the possibility that we might be committing a Type II error. If we do not reject H 0 , we conclude that we do not have significant evidence to show that H 1 is true. We do not conclude that H 0 is true.
The most common reason for a Type II error is a small sample size.
Tests with One Sample, Continuous Outcome
Hypothesis testing applications with a continuous outcome variable in a single population are performed according to the five-step procedure outlined above. A key component is setting up the null and research hypotheses. The objective is to compare the mean in a single population to known mean (μ 0 ). The known value is generally derived from another study or report, for example a study in a similar, but not identical, population or a study performed some years ago. The latter is called a historical control. It is important in setting up the hypotheses in a one sample test that the mean specified in the null hypothesis is a fair and reasonable comparator. This will be discussed in the examples that follow.
Test Statistics for Testing H 0 : μ= μ 0
if n > 30
if n < 30
Note that statistical computing packages will use the t statistic exclusively and make the necessary adjustments for comparing the test statistic to appropriate values from probability tables to produce a p-value.
The National Center for Health Statistics (NCHS) published a report in 2005 entitled Health, United States, containing extensive information on major trends in the health of Americans. Data are provided for the US population as a whole and for specific ages, sexes and races. The NCHS report indicated that in 2002 Americans paid an average of $3,302 per year on health care and prescription drugs. An investigator hypothesizes that in 2005 expenditures have decreased primarily due to the availability of generic drugs. To test the hypothesis, a sample of 100 Americans are selected and their expenditures on health care and prescription drugs in 2005 are measured. The sample data are summarized as follows: n=100, x̄
=$3,190 and s=$890. Is there statistical evidence of a reduction in expenditures on health care and prescription drugs in 2005? Is the sample mean of $3,190 evidence of a true reduction in the mean or is it within chance fluctuation? We will run the test using the five-step approach.
Step 1. Set up hypotheses and determine level of significance
H 0 : μ = 3,302 H 1 : μ < 3,302 α =0.05
The research hypothesis is that expenditures have decreased, and therefore a lower-tailed test is used.
This is a lower tailed test, using a Z statistic and a 5% level of significance. Reject H 0 if Z < -1.645.
Step 4. Compute the test statistic.
We do not reject H 0 because -1.26 > -1.645. We do not have statistically significant evidence at α=0.05 to show that the mean expenditures on health care and prescription drugs are lower in 2005 than the mean of $3,302 reported in 2002.
Recall that when we fail to reject H 0 in a test of hypothesis that either the null hypothesis is true (here the mean expenditures in 2005 are the same as those in 2002 and equal to $3,302) or we committed a Type II error (i.e., we failed to reject H 0 when in fact it is false). In summarizing this test, we conclude that we do not have sufficient evidence to reject H 0 . We do not conclude that H 0 is true, because there may be a moderate to high probability that we committed a Type II error. It is possible that the sample size is not large enough to detect a difference in mean expenditures.
The NCHS reported that the mean total cholesterol level in 2002 for all adults was 203. Total cholesterol levels in participants who attended the seventh examination of the Offspring in the Framingham Heart Study are summarized as follows: n=3,310, x̄ =200.3, and s=36.8. Is there statistical evidence of a difference in mean cholesterol levels in the Framingham Offspring?
Here we want to assess whether the sample mean of 200.3 in the Framingham sample is statistically significantly different from 203 (i.e., beyond what we would expect by chance). We will run the test using the five-step approach.
H 0 : μ= 203 H 1 : μ≠ 203 α=0.05
The research hypothesis is that cholesterol levels are different in the Framingham Offspring, and therefore a two-tailed test is used.
Step 3. Set up decision rule.
This is a two-tailed test, using a Z statistic and a 5% level of significance. Reject H 0 if Z < -1.960 or is Z > 1.960.
We reject H 0 because -4.22 ≤ -1. .960. We have statistically significant evidence at α=0.05 to show that the mean total cholesterol level in the Framingham Offspring is different from the national average of 203 reported in 2002. Because we reject H 0 , we also approximate a p-value. Using the two-sided significance levels, p < 0.0001.
Statistical Significance versus Clinical (Practical) Significance
This example raises an important concept of statistical versus clinical or practical significance. From a statistical standpoint, the total cholesterol levels in the Framingham sample are highly statistically significantly different from the national average with p < 0.0001 (i.e., there is less than a 0.01% chance that we are incorrectly rejecting the null hypothesis). However, the sample mean in the Framingham Offspring study is 200.3, less than 3 units different from the national mean of 203. The reason that the data are so highly statistically significant is due to the very large sample size. It is always important to assess both statistical and clinical significance of data. This is particularly relevant when the sample size is large. Is a 3 unit difference in total cholesterol a meaningful difference?
Consider again the NCHS-reported mean total cholesterol level in 2002 for all adults of 203. Suppose a new drug is proposed to lower total cholesterol. A study is designed to evaluate the efficacy of the drug in lowering cholesterol. Fifteen patients are enrolled in the study and asked to take the new drug for 6 weeks. At the end of 6 weeks, each patient's total cholesterol level is measured and the sample statistics are as follows: n=15, x̄ =195.9 and s=28.7. Is there statistical evidence of a reduction in mean total cholesterol in patients after using the new drug for 6 weeks? We will run the test using the five-step approach.
H 0 : μ= 203 H 1 : μ< 203 α=0.05
Step 2. Select the appropriate test statistic.
Because the sample size is small (n<30) the appropriate test statistic is
This is a lower tailed test, using a t statistic and a 5% level of significance. In order to determine the critical value of t, we need degrees of freedom, df, defined as df=n-1. In this example df=15-1=14. The critical value for a lower tailed test with df=14 and a =0.05 is -2.145 and the decision rule is as follows: Reject H 0 if t < -2.145.
We do not reject H 0 because -0.96 > -2.145. We do not have statistically significant evidence at α=0.05 to show that the mean total cholesterol level is lower than the national mean in patients taking the new drug for 6 weeks. Again, because we failed to reject the null hypothesis we make a weaker concluding statement allowing for the possibility that we may have committed a Type II error (i.e., failed to reject H 0 when in fact the drug is efficacious).
This example raises an important issue in terms of study design. In this example we assume in the null hypothesis that the mean cholesterol level is 203. This is taken to be the mean cholesterol level in patients without treatment. Is this an appropriate comparator? Alternative and potentially more efficient study designs to evaluate the effect of the new drug could involve two treatment groups, where one group receives the new drug and the other does not, or we could measure each patient's baseline or pre-treatment cholesterol level and then assess changes from baseline to 6 weeks post-treatment. These designs are also discussed here.
Video - Comparing a Sample Mean to Known Population Mean (8:20)
Link to transcript of the video
Tests with One Sample, Dichotomous Outcome
Hypothesis testing applications with a dichotomous outcome variable in a single population are also performed according to the five-step procedure. Similar to tests for means, a key component is setting up the null and research hypotheses. The objective is to compare the proportion of successes in a single population to a known proportion (p 0 ). That known proportion is generally derived from another study or report and is sometimes called a historical control. It is important in setting up the hypotheses in a one sample test that the proportion specified in the null hypothesis is a fair and reasonable comparator.
In one sample tests for a dichotomous outcome, we set up our hypotheses against an appropriate comparator. We select a sample and compute descriptive statistics on the sample data. Specifically, we compute the sample size (n) and the sample proportion which is computed by taking the ratio of the number of successes to the sample size,
We then determine the appropriate test statistic (Step 2) for the hypothesis test. The formula for the test statistic is given below.
Test Statistic for Testing H 0 : p = p 0
if min(np 0 , n(1-p 0 )) > 5
The formula above is appropriate for large samples, defined when the smaller of np 0 and n(1-p 0 ) is at least 5. This is similar, but not identical, to the condition required for appropriate use of the confidence interval formula for a population proportion, i.e.,
Here we use the proportion specified in the null hypothesis as the true proportion of successes rather than the sample proportion. If we fail to satisfy the condition, then alternative procedures, called exact methods must be used to test the hypothesis about the population proportion.
Example:
The NCHS report indicated that in 2002 the prevalence of cigarette smoking among American adults was 21.1%. Data on prevalent smoking in n=3,536 participants who attended the seventh examination of the Offspring in the Framingham Heart Study indicated that 482/3,536 = 13.6% of the respondents were currently smoking at the time of the exam. Suppose we want to assess whether the prevalence of smoking is lower in the Framingham Offspring sample given the focus on cardiovascular health in that community. Is there evidence of a statistically lower prevalence of smoking in the Framingham Offspring study as compared to the prevalence among all Americans?
H 0 : p = 0.211 H 1 : p < 0.211 α=0.05
We must first check that the sample size is adequate. Specifically, we need to check min(np 0 , n(1-p 0 )) = min( 3,536(0.211), 3,536(1-0.211))=min(746, 2790)=746. The sample size is more than adequate so the following formula can be used:
This is a lower tailed test, using a Z statistic and a 5% level of significance. Reject H 0 if Z < -1.645.
We reject H 0 because -10.93 < -1.645. We have statistically significant evidence at α=0.05 to show that the prevalence of smoking in the Framingham Offspring is lower than the prevalence nationally (21.1%). Here, p < 0.0001.
The NCHS report indicated that in 2002, 75% of children aged 2 to 17 saw a dentist in the past year. An investigator wants to assess whether use of dental services is similar in children living in the city of Boston. A sample of 125 children aged 2 to 17 living in Boston are surveyed and 64 reported seeing a dentist over the past 12 months. Is there a significant difference in use of dental services between children living in Boston and the national data?
Calculate this on your own before checking the answer.
Video - Hypothesis Test for One Sample and a Dichotomous Outcome (3:55)
Tests with Two Independent Samples, Continuous Outcome
There are many applications where it is of interest to compare two independent groups with respect to their mean scores on a continuous outcome. Here we compare means between groups, but rather than generating an estimate of the difference, we will test whether the observed difference (increase, decrease or difference) is statistically significant or not. Remember, that hypothesis testing gives an assessment of statistical significance, whereas estimation gives an estimate of effect and both are important.
Here we discuss the comparison of means when the two comparison groups are independent or physically separate. The two groups might be determined by a particular attribute (e.g., sex, diagnosis of cardiovascular disease) or might be set up by the investigator (e.g., participants assigned to receive an experimental treatment or placebo). The first step in the analysis involves computing descriptive statistics on each of the two samples. Specifically, we compute the sample size, mean and standard deviation in each sample and we denote these summary statistics as follows:
for sample 1:
for sample 2:
The designation of sample 1 and sample 2 is arbitrary. In a clinical trial setting the convention is to call the treatment group 1 and the control group 2. However, when comparing men and women, for example, either group can be 1 or 2.
In the two independent samples application with a continuous outcome, the parameter of interest in the test of hypothesis is the difference in population means, μ 1 -μ 2 . The null hypothesis is always that there is no difference between groups with respect to means, i.e.,
The null hypothesis can also be written as follows: H 0 : μ 1 = μ 2 . In the research hypothesis, an investigator can hypothesize that the first mean is larger than the second (H 1 : μ 1 > μ 2 ), that the first mean is smaller than the second (H 1 : μ 1 < μ 2 ), or that the means are different (H 1 : μ 1 ≠ μ 2 ). The three different alternatives represent upper-, lower-, and two-tailed tests, respectively. The following test statistics are used to test these hypotheses.
Test Statistics for Testing H 0 : μ 1 = μ 2
if n 1 > 30 and n 2 > 30
if n 1 < 30 or n 2 < 30
NOTE: The formulas above assume equal variability in the two populations (i.e., the population variances are equal, or s 1 2 = s 2 2 ). This means that the outcome is equally variable in each of the comparison populations. For analysis, we have samples from each of the comparison populations. If the sample variances are similar, then the assumption about variability in the populations is probably reasonable. As a guideline, if the ratio of the sample variances, s 1 2 /s 2 2 is between 0.5 and 2 (i.e., if one variance is no more than double the other), then the formulas above are appropriate. If the ratio of the sample variances is greater than 2 or less than 0.5 then alternative formulas must be used to account for the heterogeneity in variances.
The test statistics include Sp, which is the pooled estimate of the common standard deviation (again assuming that the variances in the populations are similar) computed as the weighted average of the standard deviations in the samples as follows:
Because we are assuming equal variances between groups, we pool the information on variability (sample variances) to generate an estimate of the variability in the population. Note: Because Sp is a weighted average of the standard deviations in the sample, Sp will always be in between s 1 and s 2 .)
Data measured on n=3,539 participants who attended the seventh examination of the Offspring in the Framingham Heart Study are shown below.
Characteristic
n
S
n
s
Systolic Blood Pressure
1,623
128.2
17.5
1,911
126.5
20.1
Diastolic Blood Pressure
1,622
75.6
9.8
1,910
72.6
9.7
Total Serum Cholesterol
1,544
192.4
35.2
1,766
207.1
36.7
Weight
1,612
194.0
33.8
1,894
157.7
34.6
Height
1,545
68.9
2.7
1,781
63.4
2.5
Body Mass Index
1,545
28.8
4.6
1,781
27.6
5.9
Suppose we now wish to assess whether there is a statistically significant difference in mean systolic blood pressures between men and women using a 5% level of significance.
H 0 : μ 1 = μ 2
H 1 : μ 1 ≠ μ 2 α=0.05
Because both samples are large ( > 30), we can use the Z test statistic as opposed to t. Note that statistical computing packages use t throughout. Before implementing the formula, we first check whether the assumption of equality of population variances is reasonable. The guideline suggests investigating the ratio of the sample variances, s 1 2 /s 2 2 . Suppose we call the men group 1 and the women group 2. Again, this is arbitrary; it only needs to be noted when interpreting the results. The ratio of the sample variances is 17.5 2 /20.1 2 = 0.76, which falls between 0.5 and 2 suggesting that the assumption of equality of population variances is reasonable. The appropriate test statistic is
We now substitute the sample data into the formula for the test statistic identified in Step 2. Before substituting, we will first compute Sp, the pooled estimate of the common standard deviation.
Notice that the pooled estimate of the common standard deviation, Sp, falls in between the standard deviations in the comparison groups (i.e., 17.5 and 20.1). Sp is slightly closer in value to the standard deviation in the women (20.1) as there were slightly more women in the sample. Recall, Sp is a weight average of the standard deviations in the comparison groups, weighted by the respective sample sizes.
Now the test statistic:
We reject H 0 because 2.66 > 1.960. We have statistically significant evidence at α=0.05 to show that there is a difference in mean systolic blood pressures between men and women. The p-value is p < 0.010.
Here again we find that there is a statistically significant difference in mean systolic blood pressures between men and women at p < 0.010. Notice that there is a very small difference in the sample means (128.2-126.5 = 1.7 units), but this difference is beyond what would be expected by chance. Is this a clinically meaningful difference? The large sample size in this example is driving the statistical significance. A 95% confidence interval for the difference in mean systolic blood pressures is: 1.7 + 1.26 or (0.44, 2.96). The confidence interval provides an assessment of the magnitude of the difference between means whereas the test of hypothesis and p-value provide an assessment of the statistical significance of the difference.
Above we performed a study to evaluate a new drug designed to lower total cholesterol. The study involved one sample of patients, each patient took the new drug for 6 weeks and had their cholesterol measured. As a means of evaluating the efficacy of the new drug, the mean total cholesterol following 6 weeks of treatment was compared to the NCHS-reported mean total cholesterol level in 2002 for all adults of 203. At the end of the example, we discussed the appropriateness of the fixed comparator as well as an alternative study design to evaluate the effect of the new drug involving two treatment groups, where one group receives the new drug and the other does not. Here, we revisit the example with a concurrent or parallel control group, which is very typical in randomized controlled trials or clinical trials (refer to the EP713 module on Clinical Trials).
A new drug is proposed to lower total cholesterol. A randomized controlled trial is designed to evaluate the efficacy of the medication in lowering cholesterol. Thirty participants are enrolled in the trial and are randomly assigned to receive either the new drug or a placebo. The participants do not know which treatment they are assigned. Each participant is asked to take the assigned treatment for 6 weeks. At the end of 6 weeks, each patient's total cholesterol level is measured and the sample statistics are as follows.
Treatment
New Drug
15
195.9
28.7
Placebo
15
227.4
30.3
Is there statistical evidence of a reduction in mean total cholesterol in patients taking the new drug for 6 weeks as compared to participants taking placebo? We will run the test using the five-step approach.
H 0 : μ 1 = μ 2 H 1 : μ 1 < μ 2 α=0.05
Because both samples are small (< 30), we use the t test statistic. Before implementing the formula, we first check whether the assumption of equality of population variances is reasonable. The ratio of the sample variances, s 1 2 /s 2 2 =28.7 2 /30.3 2 = 0.90, which falls between 0.5 and 2, suggesting that the assumption of equality of population variances is reasonable. The appropriate test statistic is:
This is a lower-tailed test, using a t statistic and a 5% level of significance. The appropriate critical value can be found in the t Table (in More Resources to the right). In order to determine the critical value of t we need degrees of freedom, df, defined as df=n 1 +n 2 -2 = 15+15-2=28. The critical value for a lower tailed test with df=28 and α=0.05 is -1.701 and the decision rule is: Reject H 0 if t < -1.701.
Now the test statistic,
We reject H 0 because -2.92 < -1.701. We have statistically significant evidence at α=0.05 to show that the mean total cholesterol level is lower in patients taking the new drug for 6 weeks as compared to patients taking placebo, p < 0.005.
The clinical trial in this example finds a statistically significant reduction in total cholesterol, whereas in the previous example where we had a historical control (as opposed to a parallel control group) we did not demonstrate efficacy of the new drug. Notice that the mean total cholesterol level in patients taking placebo is 217.4 which is very different from the mean cholesterol reported among all Americans in 2002 of 203 and used as the comparator in the prior example. The historical control value may not have been the most appropriate comparator as cholesterol levels have been increasing over time. In the next section, we present another design that can be used to assess the efficacy of the new drug.
Video - Comparison of Two Independent Samples With a Continuous Outcome (8:02)
Tests with Matched Samples, Continuous Outcome
In the previous section we compared two groups with respect to their mean scores on a continuous outcome. An alternative study design is to compare matched or paired samples. The two comparison groups are said to be dependent, and the data can arise from a single sample of participants where each participant is measured twice (possibly before and after an intervention) or from two samples that are matched on specific characteristics (e.g., siblings). When the samples are dependent, we focus on difference scores in each participant or between members of a pair and the test of hypothesis is based on the mean difference, μ d . The null hypothesis again reflects "no difference" and is stated as H 0 : μ d =0 . Note that there are some instances where it is of interest to test whether there is a difference of a particular magnitude (e.g., μ d =5) but in most instances the null hypothesis reflects no difference (i.e., μ d =0).
The appropriate formula for the test of hypothesis depends on the sample size. The formulas are shown below and are identical to those we presented for estimating the mean of a single sample presented (e.g., when comparing against an external or historical control), except here we focus on difference scores.
Test Statistics for Testing H 0 : μ d =0
A new drug is proposed to lower total cholesterol and a study is designed to evaluate the efficacy of the drug in lowering cholesterol. Fifteen patients agree to participate in the study and each is asked to take the new drug for 6 weeks. However, before starting the treatment, each patient's total cholesterol level is measured. The initial measurement is a pre-treatment or baseline value. After taking the drug for 6 weeks, each patient's total cholesterol level is measured again and the data are shown below. The rightmost column contains difference scores for each patient, computed by subtracting the 6 week cholesterol level from the baseline level. The differences represent the reduction in total cholesterol over 4 weeks. (The differences could have been computed by subtracting the baseline total cholesterol level from the level measured at 6 weeks. The way in which the differences are computed does not affect the outcome of the analysis only the interpretation.)
1
215
205
10
2
190
156
34
3
230
190
40
4
220
180
40
5
214
201
13
6
240
227
13
7
210
197
13
8
193
173
20
9
210
204
6
10
230
217
13
11
180
142
38
12
260
262
-2
13
210
207
3
14
190
184
6
15
200
193
7
Because the differences are computed by subtracting the cholesterols measured at 6 weeks from the baseline values, positive differences indicate reductions and negative differences indicate increases (e.g., participant 12 increases by 2 units over 6 weeks). The goal here is to test whether there is a statistically significant reduction in cholesterol. Because of the way in which we computed the differences, we want to look for an increase in the mean difference (i.e., a positive reduction). In order to conduct the test, we need to summarize the differences. In this sample, we have
The calculations are shown below.
1
10
100
2
34
1156
3
40
1600
4
40
1600
5
13
169
6
13
169
7
13
169
8
20
400
9
6
36
10
13
169
11
38
1444
12
-2
4
13
3
9
14
6
36
15
7
49
Is there statistical evidence of a reduction in mean total cholesterol in patients after using the new medication for 6 weeks? We will run the test using the five-step approach.
H 0 : μ d = 0 H 1 : μ d > 0 α=0.05
NOTE: If we had computed differences by subtracting the baseline level from the level measured at 6 weeks then negative differences would have reflected reductions and the research hypothesis would have been H 1 : μ d < 0.
Step 2 . Select the appropriate test statistic.
This is an upper-tailed test, using a t statistic and a 5% level of significance. The appropriate critical value can be found in the t Table at the right, with df=15-1=14. The critical value for an upper-tailed test with df=14 and α=0.05 is 2.145 and the decision rule is Reject H 0 if t > 2.145.
We now substitute the sample data into the formula for the test statistic identified in Step 2.
We reject H 0 because 4.61 > 2.145. We have statistically significant evidence at α=0.05 to show that there is a reduction in cholesterol levels over 6 weeks.
Here we illustrate the use of a matched design to test the efficacy of a new drug to lower total cholesterol. We also considered a parallel design (randomized clinical trial) and a study using a historical comparator. It is extremely important to design studies that are best suited to detect a meaningful difference when one exists. There are often several alternatives and investigators work with biostatisticians to determine the best design for each application. It is worth noting that the matched design used here can be problematic in that observed differences may only reflect a "placebo" effect. All participants took the assigned medication, but is the observed reduction attributable to the medication or a result of these participation in a study.
Video - Hypothesis Testing With a Matched Sample and a Continuous Outcome (3:11)
Tests with Two Independent Samples, Dichotomous Outcome
There are several approaches that can be used to test hypotheses concerning two independent proportions. Here we present one approach - the chi-square test of independence is an alternative, equivalent, and perhaps more popular approach to the same analysis. Hypothesis testing with the chi-square test is addressed in the third module in this series: BS704_HypothesisTesting-ChiSquare.
In tests of hypothesis comparing proportions between two independent groups, one test is performed and results can be interpreted to apply to a risk difference, relative risk or odds ratio. As a reminder, the risk difference is computed by taking the difference in proportions between comparison groups, the risk ratio is computed by taking the ratio of proportions, and the odds ratio is computed by taking the ratio of the odds of success in the comparison groups. Because the null values for the risk difference, the risk ratio and the odds ratio are different, the hypotheses in tests of hypothesis look slightly different depending on which measure is used. When performing tests of hypothesis for the risk difference, relative risk or odds ratio, the convention is to label the exposed or treated group 1 and the unexposed or control group 2.
For example, suppose a study is designed to assess whether there is a significant difference in proportions in two independent comparison groups. The test of interest is as follows:
H 0 : p 1 = p 2 versus H 1 : p 1 ≠ p 2 .
The following are the hypothesis for testing for a difference in proportions using the risk difference, the risk ratio and the odds ratio. First, the hypotheses above are equivalent to the following:
For the risk difference, H 0 : p 1 - p 2 = 0 versus H 1 : p 1 - p 2 ≠ 0 which are, by definition, equal to H 0 : RD = 0 versus H 1 : RD ≠ 0.
If an investigator wants to focus on the risk ratio, the equivalent hypotheses are H 0 : RR = 1 versus H 1 : RR ≠ 1.
If the investigator wants to focus on the odds ratio, the equivalent hypotheses are H 0 : OR = 1 versus H 1 : OR ≠ 1.
Suppose a test is performed to test H 0 : RD = 0 versus H 1 : RD ≠ 0 and the test rejects H 0 at α=0.05. Based on this test we can conclude that there is significant evidence, α=0.05, of a difference in proportions, significant evidence that the risk difference is not zero, significant evidence that the risk ratio and odds ratio are not one. The risk difference is analogous to the difference in means when the outcome is continuous. Here the parameter of interest is the difference in proportions in the population, RD = p 1 -p 2 and the null value for the risk difference is zero. In a test of hypothesis for the risk difference, the null hypothesis is always H 0 : RD = 0. This is equivalent to H 0 : RR = 1 and H 0 : OR = 1. In the research hypothesis, an investigator can hypothesize that the first proportion is larger than the second (H 1 : p 1 > p 2 , which is equivalent to H 1 : RD > 0, H 1 : RR > 1 and H 1 : OR > 1), that the first proportion is smaller than the second (H 1 : p 1 < p 2 , which is equivalent to H 1 : RD < 0, H 1 : RR < 1 and H 1 : OR < 1), or that the proportions are different (H 1 : p 1 ≠ p 2 , which is equivalent to H 1 : RD ≠ 0, H 1 : RR ≠ 1 and H 1 : OR ≠
1). The three different alternatives represent upper-, lower- and two-tailed tests, respectively.
The formula for the test of hypothesis for the difference in proportions is given below.
Test Statistics for Testing H 0 : p 1 = p
The formula above is appropriate for large samples, defined as at least 5 successes (np > 5) and at least 5 failures (n(1-p > 5)) in each of the two samples. If there are fewer than 5 successes or failures in either comparison group, then alternative procedures, called exact methods must be used to estimate the difference in population proportions.
The following table summarizes data from n=3,799 participants who attended the fifth examination of the Offspring in the Framingham Heart Study. The outcome of interest is prevalent CVD and we want to test whether the prevalence of CVD is significantly higher in smokers as compared to non-smokers.
Free of CVD
History of CVD
Total
Non-Smoker
2,757
298
3,055
Current Smoker
663
81
744
Total
3,420
379
3,799
The prevalence of CVD (or proportion of participants with prevalent CVD) among non-smokers is 298/3,055 = 0.0975 and the prevalence of CVD among current smokers is 81/744 = 0.1089. Here smoking status defines the comparison groups and we will call the current smokers group 1 (exposed) and the non-smokers (unexposed) group 2. The test of hypothesis is conducted below using the five step approach.
H 0 : p 1 = p 2 H 1 : p 1 ≠ p 2 α=0.05
Step 2. Select the appropriate test statistic.
We must first check that the sample size is adequate. Specifically, we need to ensure that we have at least 5 successes and 5 failures in each comparison group. In this example, we have more than enough successes (cases of prevalent CVD) and failures (persons free of CVD) in each comparison group. The sample size is more than adequate so the following formula can be used:
Reject H 0 if Z < -1.960 or if Z > 1.960.
We now substitute the sample data into the formula for the test statistic identified in Step 2. We first compute the overall proportion of successes:
We now substitute to compute the test statistic.
Step 5. Conclusion.
We do not reject H 0 because -1.960 < 0.927 < 1.960. We do not have statistically significant evidence at α=0.05 to show that there is a difference in prevalent CVD between smokers and non-smokers.
A 95% confidence interval for the difference in prevalent CVD (or risk difference) between smokers and non-smokers as 0.0114 + 0.0247, or between -0.0133 and 0.0361. Because the 95% confidence interval for the risk difference includes zero we again conclude that there is no statistically significant difference in prevalent CVD between smokers and non-smokers.
Smoking has been shown over and over to be a risk factor for cardiovascular disease. What might explain the fact that we did not observe a statistically significant difference using data from the Framingham Heart Study? HINT: Here we consider prevalent CVD, would the results have been different if we considered incident CVD?
A randomized trial is designed to evaluate the effectiveness of a newly developed pain reliever designed to reduce pain in patients following joint replacement surgery. The trial compares the new pain reliever to the pain reliever currently in use (called the standard of care). A total of 100 patients undergoing joint replacement surgery agreed to participate in the trial. Patients were randomly assigned to receive either the new pain reliever or the standard pain reliever following surgery and were blind to the treatment assignment. Before receiving the assigned treatment, patients were asked to rate their pain on a scale of 0-10 with higher scores indicative of more pain. Each patient was then given the assigned treatment and after 30 minutes was again asked to rate their pain on the same scale. The primary outcome was a reduction in pain of 3 or more scale points (defined by clinicians as a clinically meaningful reduction). The following data were observed in the trial.
New Pain Reliever
50
23
0.46
Standard Pain Reliever
50
11
0.22
We now test whether there is a statistically significant difference in the proportions of patients reporting a meaningful reduction (i.e., a reduction of 3 or more scale points) using the five step approach.
H 0 : p 1 = p 2 H 1 : p 1 ≠ p 2 α=0.05
Here the new or experimental pain reliever is group 1 and the standard pain reliever is group 2.
We must first check that the sample size is adequate. Specifically, we need to ensure that we have at least 5 successes and 5 failures in each comparison group, i.e.,
In this example, we have min(50(0.46), 50(1-0.46), 50(0.22), 50(1-0.22)) = min(23, 27, 11, 39) = 11. The sample size is adequate so the following formula can be used
We reject H 0 because 2.526 > 1960. We have statistically significant evidence at a =0.05 to show that there is a difference in the proportions of patients on the new pain reliever reporting a meaningful reduction (i.e., a reduction of 3 or more scale points) as compared to patients on the standard pain reliever.
A 95% confidence interval for the difference in proportions of patients on the new pain reliever reporting a meaningful reduction (i.e., a reduction of 3 or more scale points) as compared to patients on the standard pain reliever is 0.24 + 0.18 or between 0.06 and 0.42. Because the 95% confidence interval does not include zero we concluded that there was a statistically significant difference in proportions which is consistent with the test of hypothesis result.
Again, the procedures discussed here apply to applications where there are two independent comparison groups and a dichotomous outcome. There are other applications in which it is of interest to compare a dichotomous outcome in matched or paired samples. For example, in a clinical trial we might wish to test the effectiveness of a new antibiotic eye drop for the treatment of bacterial conjunctivitis. Participants use the new antibiotic eye drop in one eye and a comparator (placebo or active control treatment) in the other. The success of the treatment (yes/no) is recorded for each participant for each eye. Because the two assessments (success or failure) are paired, we cannot use the procedures discussed here. The appropriate test is called McNemar's test (sometimes called McNemar's test for dependent proportions).
Vide0 - Hypothesis Testing With Two Independent Samples and a Dichotomous Outcome (2:55)
Here we presented hypothesis testing techniques for means and proportions in one and two sample situations. Tests of hypothesis involve several steps, including specifying the null and alternative or research hypothesis, selecting and computing an appropriate test statistic, setting up a decision rule and drawing a conclusion. There are many details to consider in hypothesis testing. The first is to determine the appropriate test. We discussed Z and t tests here for different applications. The appropriate test depends on the distribution of the outcome variable (continuous or dichotomous), the number of comparison groups (one, two) and whether the comparison groups are independent or dependent. The following table summarizes the different tests of hypothesis discussed here.
Continuous Outcome, One Sample: H0: μ = μ0
Continuous Outcome, Two Independent Samples: H0: μ1 = μ2
Continuous Outcome, Two Matched Samples: H0: μd = 0
Once the type of test is determined, the details of the test must be specified. Specifically, the null and alternative hypotheses must be clearly stated. The null hypothesis always reflects the "no change" or "no difference" situation. The alternative or research hypothesis reflects the investigator's belief. The investigator might hypothesize that a parameter (e.g., a mean, proportion, difference in means or proportions) will increase, will decrease or will be different under specific conditions (sometimes the conditions are different experimental conditions and other times the conditions are simply different groups of participants). Once the hypotheses are specified, data are collected and summarized. The appropriate test is then conducted according to the five step approach. If the test leads to rejection of the null hypothesis, an approximate p-value is computed to summarize the significance of the findings. When tests of hypothesis are conducted using statistical computing packages, exact p-values are computed. Because the statistical tables in this textbook are limited, we can only approximate p-values. If the test fails to reject the null hypothesis, then a weaker concluding statement is made for the following reason.
In hypothesis testing, there are two types of errors that can be committed. A Type I error occurs when a test incorrectly rejects the null hypothesis. This is referred to as a false positive result, and the probability that this occurs is equal to the level of significance, α. The investigator chooses the level of significance in Step 1, and purposely chooses a small value such as α=0.05 to control the probability of committing a Type I error. A Type II error occurs when a test fails to reject the null hypothesis when in fact it is false. The probability that this occurs is equal to β. Unfortunately, the investigator cannot specify β at the outset because it depends on several factors including the sample size (smaller samples have higher b), the level of significance (β decreases as a increases), and the difference in the parameter under the null and alternative hypothesis.
We noted in several examples in this chapter, the relationship between confidence intervals and tests of hypothesis. The approaches are different, yet related. It is possible to draw a conclusion about statistical significance by examining a confidence interval. For example, if a 95% confidence interval does not contain the null value (e.g., zero when analyzing a mean difference or risk difference, one when analyzing relative risks or odds ratios), then one can conclude that a two-sided test of hypothesis would reject the null at α=0.05. It is important to note that the correspondence between a confidence interval and test of hypothesis relates to a two-sided test and that the confidence level corresponds to a specific level of significance (e.g., 95% to α=0.05, 90% to α=0.10 and so on). The exact significance of the test, the p-value, can only be determined using the hypothesis testing approach and the p-value provides an assessment of the strength of the evidence and not an estimate of the effect.
Answers to Selected Problems
Dental services problem - bottom of page 5.
Step 1: Set up hypotheses and determine the level of significance.
α=0.05
Step 2: Select the appropriate test statistic.
First, determine whether the sample size is adequate.
Therefore the sample size is adequate, and we can use the following formula:
Step 3: Set up the decision rule.
Reject H0 if Z is less than or equal to -1.96 or if Z is greater than or equal to 1.96.
Step 4: Compute the test statistic
Step 5: Conclusion.
We reject the null hypothesis because -6.15<-1.96. Therefore there is a statistically significant difference in the proportion of children in Boston using dental services compated to the national proportion.
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Knowledge Base
Methodology
How to Write a Strong Hypothesis | Steps & Examples
How to Write a Strong Hypothesis | Steps & Examples
Published on May 6, 2022 by Shona McCombes . Revised on November 20, 2023.
A hypothesis is a statement that can be tested by scientific research. If you want to test a relationship between two or more variables, you need to write hypotheses before you start your experiment or data collection .
Example: Hypothesis
Daily apple consumption leads to fewer doctor’s visits.
Table of contents
What is a hypothesis, developing a hypothesis (with example), hypothesis examples, other interesting articles, frequently asked questions about writing hypotheses.
A hypothesis states your predictions about what your research will find. It is a tentative answer to your research question that has not yet been tested. For some research projects, you might have to write several hypotheses that address different aspects of your research question.
A hypothesis is not just a guess – it should be based on existing theories and knowledge. It also has to be testable, which means you can support or refute it through scientific research methods (such as experiments, observations and statistical analysis of data).
Variables in hypotheses
Hypotheses propose a relationship between two or more types of variables .
An independent variable is something the researcher changes or controls.
A dependent variable is something the researcher observes and measures.
If there are any control variables , extraneous variables , or confounding variables , be sure to jot those down as you go to minimize the chances that research bias will affect your results.
In this example, the independent variable is exposure to the sun – the assumed cause . The dependent variable is the level of happiness – the assumed effect .
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Step 1. ask a question.
Writing a hypothesis begins with a research question that you want to answer. The question should be focused, specific, and researchable within the constraints of your project.
Step 2. Do some preliminary research
Your initial answer to the question should be based on what is already known about the topic. Look for theories and previous studies to help you form educated assumptions about what your research will find.
At this stage, you might construct a conceptual framework to ensure that you’re embarking on a relevant topic . This can also help you identify which variables you will study and what you think the relationships are between them. Sometimes, you’ll have to operationalize more complex constructs.
Step 3. Formulate your hypothesis
Now you should have some idea of what you expect to find. Write your initial answer to the question in a clear, concise sentence.
4. Refine your hypothesis
You need to make sure your hypothesis is specific and testable. There are various ways of phrasing a hypothesis, but all the terms you use should have clear definitions, and the hypothesis should contain:
The relevant variables
The specific group being studied
The predicted outcome of the experiment or analysis
5. Phrase your hypothesis in three ways
To identify the variables, you can write a simple prediction in if…then form. The first part of the sentence states the independent variable and the second part states the dependent variable.
In academic research, hypotheses are more commonly phrased in terms of correlations or effects, where you directly state the predicted relationship between variables.
If you are comparing two groups, the hypothesis can state what difference you expect to find between them.
6. Write a null hypothesis
If your research involves statistical hypothesis testing , you will also have to write a null hypothesis . The null hypothesis is the default position that there is no association between the variables. The null hypothesis is written as H 0 , while the alternative hypothesis is H 1 or H a .
H 0 : The number of lectures attended by first-year students has no effect on their final exam scores.
H 1 : The number of lectures attended by first-year students has a positive effect on their final exam scores.
Research question
Hypothesis
Null hypothesis
What are the health benefits of eating an apple a day?
Increasing apple consumption in over-60s will result in decreasing frequency of doctor’s visits.
Increasing apple consumption in over-60s will have no effect on frequency of doctor’s visits.
Which airlines have the most delays?
Low-cost airlines are more likely to have delays than premium airlines.
Low-cost and premium airlines are equally likely to have delays.
Can flexible work arrangements improve job satisfaction?
Employees who have flexible working hours will report greater job satisfaction than employees who work fixed hours.
There is no relationship between working hour flexibility and job satisfaction.
How effective is high school sex education at reducing teen pregnancies?
Teenagers who received sex education lessons throughout high school will have lower rates of unplanned pregnancy teenagers who did not receive any sex education.
High school sex education has no effect on teen pregnancy rates.
What effect does daily use of social media have on the attention span of under-16s?
There is a negative between time spent on social media and attention span in under-16s.
There is no relationship between social media use and attention span in under-16s.
If you want to know more about the research process , methodology , research bias , or statistics , make sure to check out some of our other articles with explanations and examples.
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A hypothesis is not just a guess — it should be based on existing theories and knowledge. It also has to be testable, which means you can support or refute it through scientific research methods (such as experiments, observations and statistical analysis of data).
Null and alternative hypotheses are used in statistical hypothesis testing . The null hypothesis of a test always predicts no effect or no relationship between variables, while the alternative hypothesis states your research prediction of an effect or relationship.
Hypothesis testing is a formal procedure for investigating our ideas about the world using statistics. It is used by scientists to test specific predictions, called hypotheses , by calculating how likely it is that a pattern or relationship between variables could have arisen by chance.
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What Is Hypothesis Testing?
How It Works
4 Step Process
The bottom line.
Fundamental Analysis
Hypothesis Testing: 4 Steps and Example
Hypothesis testing, sometimes called significance testing, is an act in statistics whereby an analyst tests an assumption regarding a population parameter. The methodology employed by the analyst depends on the nature of the data used and the reason for the analysis.
Hypothesis testing is used to assess the plausibility of a hypothesis by using sample data. Such data may come from a larger population or a data-generating process. The word "population" will be used for both of these cases in the following descriptions.
Key Takeaways
Hypothesis testing is used to assess the plausibility of a hypothesis by using sample data.
The test provides evidence concerning the plausibility of the hypothesis, given the data.
Statistical analysts test a hypothesis by measuring and examining a random sample of the population being analyzed.
The four steps of hypothesis testing include stating the hypotheses, formulating an analysis plan, analyzing the sample data, and analyzing the result.
How Hypothesis Testing Works
In hypothesis testing, an analyst tests a statistical sample, intending to provide evidence on the plausibility of the null hypothesis. Statistical analysts measure and examine a random sample of the population being analyzed. All analysts use a random population sample to test two different hypotheses: the null hypothesis and the alternative hypothesis.
The null hypothesis is usually a hypothesis of equality between population parameters; e.g., a null hypothesis may state that the population mean return is equal to zero. The alternative hypothesis is effectively the opposite of a null hypothesis. Thus, they are mutually exclusive , and only one can be true. However, one of the two hypotheses will always be true.
The null hypothesis is a statement about a population parameter, such as the population mean, that is assumed to be true.
State the hypotheses.
Formulate an analysis plan, which outlines how the data will be evaluated.
Carry out the plan and analyze the sample data.
Analyze the results and either reject the null hypothesis, or state that the null hypothesis is plausible, given the data.
Example of Hypothesis Testing
If an individual wants to test that a penny has exactly a 50% chance of landing on heads, the null hypothesis would be that 50% is correct, and the alternative hypothesis would be that 50% is not correct. Mathematically, the null hypothesis is represented as Ho: P = 0.5. The alternative hypothesis is shown as "Ha" and is identical to the null hypothesis, except with the equal sign struck-through, meaning that it does not equal 50%.
A random sample of 100 coin flips is taken, and the null hypothesis is tested. If it is found that the 100 coin flips were distributed as 40 heads and 60 tails, the analyst would assume that a penny does not have a 50% chance of landing on heads and would reject the null hypothesis and accept the alternative hypothesis.
If there were 48 heads and 52 tails, then it is plausible that the coin could be fair and still produce such a result. In cases such as this where the null hypothesis is "accepted," the analyst states that the difference between the expected results (50 heads and 50 tails) and the observed results (48 heads and 52 tails) is "explainable by chance alone."
When Did Hypothesis Testing Begin?
Some statisticians attribute the first hypothesis tests to satirical writer John Arbuthnot in 1710, who studied male and female births in England after observing that in nearly every year, male births exceeded female births by a slight proportion. Arbuthnot calculated that the probability of this happening by chance was small, and therefore it was due to “divine providence.”
What are the Benefits of Hypothesis Testing?
Hypothesis testing helps assess the accuracy of new ideas or theories by testing them against data. This allows researchers to determine whether the evidence supports their hypothesis, helping to avoid false claims and conclusions. Hypothesis testing also provides a framework for decision-making based on data rather than personal opinions or biases. By relying on statistical analysis, hypothesis testing helps to reduce the effects of chance and confounding variables, providing a robust framework for making informed conclusions.
What are the Limitations of Hypothesis Testing?
Hypothesis testing relies exclusively on data and doesn’t provide a comprehensive understanding of the subject being studied. Additionally, the accuracy of the results depends on the quality of the available data and the statistical methods used. Inaccurate data or inappropriate hypothesis formulation may lead to incorrect conclusions or failed tests. Hypothesis testing can also lead to errors, such as analysts either accepting or rejecting a null hypothesis when they shouldn’t have. These errors may result in false conclusions or missed opportunities to identify significant patterns or relationships in the data.
Hypothesis testing refers to a statistical process that helps researchers determine the reliability of a study. By using a well-formulated hypothesis and set of statistical tests, individuals or businesses can make inferences about the population that they are studying and draw conclusions based on the data presented. All hypothesis testing methods have the same four-step process, which includes stating the hypotheses, formulating an analysis plan, analyzing the sample data, and analyzing the result.
Sage. " Introduction to Hypothesis Testing ," Page 4.
Elder Research. " Who Invented the Null Hypothesis? "
Formplus. " Hypothesis Testing: Definition, Uses, Limitations and Examples ."
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What Is A Research (Scientific) Hypothesis? A plain-language explainer + examples
By: Derek Jansen (MBA) | Reviewed By: Dr Eunice Rautenbach | June 2020
If you’re new to the world of research, or it’s your first time writing a dissertation or thesis, you’re probably noticing that the words “research hypothesis” and “scientific hypothesis” are used quite a bit, and you’re wondering what they mean in a research context .
“Hypothesis” is one of those words that people use loosely, thinking they understand what it means. However, it has a very specific meaning within academic research. So, it’s important to understand the exact meaning before you start hypothesizing.
Research Hypothesis 101
What is a hypothesis ?
What is a research hypothesis (scientific hypothesis)?
Requirements for a research hypothesis
Definition of a research hypothesis
The null hypothesis
What is a hypothesis?
Let’s start with the general definition of a hypothesis (not a research hypothesis or scientific hypothesis), according to the Cambridge Dictionary:
Hypothesis: an idea or explanation for something that is based on known facts but has not yet been proved.
In other words, it’s a statement that provides an explanation for why or how something works, based on facts (or some reasonable assumptions), but that has not yet been specifically tested . For example, a hypothesis might look something like this:
Hypothesis: sleep impacts academic performance.
This statement predicts that academic performance will be influenced by the amount and/or quality of sleep a student engages in – sounds reasonable, right? It’s based on reasonable assumptions , underpinned by what we currently know about sleep and health (from the existing literature). So, loosely speaking, we could call it a hypothesis, at least by the dictionary definition.
But that’s not good enough…
Unfortunately, that’s not quite sophisticated enough to describe a research hypothesis (also sometimes called a scientific hypothesis), and it wouldn’t be acceptable in a dissertation, thesis or research paper . In the world of academic research, a statement needs a few more criteria to constitute a true research hypothesis .
What is a research hypothesis?
A research hypothesis (also called a scientific hypothesis) is a statement about the expected outcome of a study (for example, a dissertation or thesis). To constitute a quality hypothesis, the statement needs to have three attributes – specificity , clarity and testability .
Let’s take a look at these more closely.
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Hypothesis Essential #1: Specificity & Clarity
A good research hypothesis needs to be extremely clear and articulate about both what’ s being assessed (who or what variables are involved ) and the expected outcome (for example, a difference between groups, a relationship between variables, etc.).
Let’s stick with our sleepy students example and look at how this statement could be more specific and clear.
Hypothesis: Students who sleep at least 8 hours per night will, on average, achieve higher grades in standardised tests than students who sleep less than 8 hours a night.
As you can see, the statement is very specific as it identifies the variables involved (sleep hours and test grades), the parties involved (two groups of students), as well as the predicted relationship type (a positive relationship). There’s no ambiguity or uncertainty about who or what is involved in the statement, and the expected outcome is clear.
Contrast that to the original hypothesis we looked at – “Sleep impacts academic performance” – and you can see the difference. “Sleep” and “academic performance” are both comparatively vague , and there’s no indication of what the expected relationship direction is (more sleep or less sleep). As you can see, specificity and clarity are key.
A statement must be testable to qualify as a research hypothesis. In other words, there needs to be a way to prove (or disprove) the statement. If it’s not testable, it’s not a hypothesis – simple as that.
For example, consider the hypothesis we mentioned earlier:
Hypothesis: Students who sleep at least 8 hours per night will, on average, achieve higher grades in standardised tests than students who sleep less than 8 hours a night.
We could test this statement by undertaking a quantitative study involving two groups of students, one that gets 8 or more hours of sleep per night for a fixed period, and one that gets less. We could then compare the standardised test results for both groups to see if there’s a statistically significant difference.
Again, if you compare this to the original hypothesis we looked at – “Sleep impacts academic performance” – you can see that it would be quite difficult to test that statement, primarily because it isn’t specific enough. How much sleep? By who? What type of academic performance?
So, remember the mantra – if you can’t test it, it’s not a hypothesis 🙂
Defining A Research Hypothesis
You’re still with us? Great! Let’s recap and pin down a clear definition of a hypothesis.
A research hypothesis (or scientific hypothesis) is a statement about an expected relationship between variables, or explanation of an occurrence, that is clear, specific and testable.
So, when you write up hypotheses for your dissertation or thesis, make sure that they meet all these criteria. If you do, you’ll not only have rock-solid hypotheses but you’ll also ensure a clear focus for your entire research project.
What about the null hypothesis?
You may have also heard the terms null hypothesis , alternative hypothesis, or H-zero thrown around. At a simple level, the null hypothesis is the counter-proposal to the original hypothesis.
For example, if the hypothesis predicts that there is a relationship between two variables (for example, sleep and academic performance), the null hypothesis would predict that there is no relationship between those variables.
At a more technical level, the null hypothesis proposes that no statistical significance exists in a set of given observations and that any differences are due to chance alone.
And there you have it – hypotheses in a nutshell.
If you have any questions, be sure to leave a comment below and we’ll do our best to help you. If you need hands-on help developing and testing your hypotheses, consider our private coaching service , where we hold your hand through the research journey.
Psst... there’s more!
This post was based on one of our popular Research Bootcamps . If you're working on a research project, you'll definitely want to check this out ...
17 Comments
Very useful information. I benefit more from getting more information in this regard.
Very great insight,educative and informative. Please give meet deep critics on many research data of public international Law like human rights, environment, natural resources, law of the sea etc
In a book I read a distinction is made between null, research, and alternative hypothesis. As far as I understand, alternative and research hypotheses are the same. Can you please elaborate? Best Afshin
This is a self explanatory, easy going site. I will recommend this to my friends and colleagues.
Very good definition. How can I cite your definition in my thesis? Thank you. Is nul hypothesis compulsory in a research?
It’s a counter-proposal to be proven as a rejection
Please what is the difference between alternate hypothesis and research hypothesis?
It is a very good explanation. However, it limits hypotheses to statistically tasteable ideas. What about for qualitative researches or other researches that involve quantitative data that don’t need statistical tests?
In qualitative research, one typically uses propositions, not hypotheses.
could you please elaborate it more
I’ve benefited greatly from these notes, thank you.
This is very helpful
well articulated ideas are presented here, thank you for being reliable sources of information
Excellent. Thanks for being clear and sound about the research methodology and hypothesis (quantitative research)
I have only a simple question regarding the null hypothesis. – Is the null hypothesis (Ho) known as the reversible hypothesis of the alternative hypothesis (H1? – How to test it in academic research?
this is very important note help me much more
Hi” best wishes to you and your very nice blog”
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Home » What is a Hypothesis – Types, Examples and Writing Guide
What is a Hypothesis – Types, Examples and Writing Guide
Table of Contents
Definition:
Hypothesis is an educated guess or proposed explanation for a phenomenon, based on some initial observations or data. It is a tentative statement that can be tested and potentially proven or disproven through further investigation and experimentation.
Hypothesis is often used in scientific research to guide the design of experiments and the collection and analysis of data. It is an essential element of the scientific method, as it allows researchers to make predictions about the outcome of their experiments and to test those predictions to determine their accuracy.
Types of Hypothesis
Types of Hypothesis are as follows:
Research Hypothesis
A research hypothesis is a statement that predicts a relationship between variables. It is usually formulated as a specific statement that can be tested through research, and it is often used in scientific research to guide the design of experiments.
Null Hypothesis
The null hypothesis is a statement that assumes there is no significant difference or relationship between variables. It is often used as a starting point for testing the research hypothesis, and if the results of the study reject the null hypothesis, it suggests that there is a significant difference or relationship between variables.
Alternative Hypothesis
An alternative hypothesis is a statement that assumes there is a significant difference or relationship between variables. It is often used as an alternative to the null hypothesis and is tested against the null hypothesis to determine which statement is more accurate.
Directional Hypothesis
A directional hypothesis is a statement that predicts the direction of the relationship between variables. For example, a researcher might predict that increasing the amount of exercise will result in a decrease in body weight.
Non-directional Hypothesis
A non-directional hypothesis is a statement that predicts the relationship between variables but does not specify the direction. For example, a researcher might predict that there is a relationship between the amount of exercise and body weight, but they do not specify whether increasing or decreasing exercise will affect body weight.
Statistical Hypothesis
A statistical hypothesis is a statement that assumes a particular statistical model or distribution for the data. It is often used in statistical analysis to test the significance of a particular result.
Composite Hypothesis
A composite hypothesis is a statement that assumes more than one condition or outcome. It can be divided into several sub-hypotheses, each of which represents a different possible outcome.
Empirical Hypothesis
An empirical hypothesis is a statement that is based on observed phenomena or data. It is often used in scientific research to develop theories or models that explain the observed phenomena.
Simple Hypothesis
A simple hypothesis is a statement that assumes only one outcome or condition. It is often used in scientific research to test a single variable or factor.
Complex Hypothesis
A complex hypothesis is a statement that assumes multiple outcomes or conditions. It is often used in scientific research to test the effects of multiple variables or factors on a particular outcome.
Applications of Hypothesis
Hypotheses are used in various fields to guide research and make predictions about the outcomes of experiments or observations. Here are some examples of how hypotheses are applied in different fields:
Science : In scientific research, hypotheses are used to test the validity of theories and models that explain natural phenomena. For example, a hypothesis might be formulated to test the effects of a particular variable on a natural system, such as the effects of climate change on an ecosystem.
Medicine : In medical research, hypotheses are used to test the effectiveness of treatments and therapies for specific conditions. For example, a hypothesis might be formulated to test the effects of a new drug on a particular disease.
Psychology : In psychology, hypotheses are used to test theories and models of human behavior and cognition. For example, a hypothesis might be formulated to test the effects of a particular stimulus on the brain or behavior.
Sociology : In sociology, hypotheses are used to test theories and models of social phenomena, such as the effects of social structures or institutions on human behavior. For example, a hypothesis might be formulated to test the effects of income inequality on crime rates.
Business : In business research, hypotheses are used to test the validity of theories and models that explain business phenomena, such as consumer behavior or market trends. For example, a hypothesis might be formulated to test the effects of a new marketing campaign on consumer buying behavior.
Engineering : In engineering, hypotheses are used to test the effectiveness of new technologies or designs. For example, a hypothesis might be formulated to test the efficiency of a new solar panel design.
How to write a Hypothesis
Here are the steps to follow when writing a hypothesis:
Identify the Research Question
The first step is to identify the research question that you want to answer through your study. This question should be clear, specific, and focused. It should be something that can be investigated empirically and that has some relevance or significance in the field.
Conduct a Literature Review
Before writing your hypothesis, it’s essential to conduct a thorough literature review to understand what is already known about the topic. This will help you to identify the research gap and formulate a hypothesis that builds on existing knowledge.
Determine the Variables
The next step is to identify the variables involved in the research question. A variable is any characteristic or factor that can vary or change. There are two types of variables: independent and dependent. The independent variable is the one that is manipulated or changed by the researcher, while the dependent variable is the one that is measured or observed as a result of the independent variable.
Formulate the Hypothesis
Based on the research question and the variables involved, you can now formulate your hypothesis. A hypothesis should be a clear and concise statement that predicts the relationship between the variables. It should be testable through empirical research and based on existing theory or evidence.
Write the Null Hypothesis
The null hypothesis is the opposite of the alternative hypothesis, which is the hypothesis that you are testing. The null hypothesis states that there is no significant difference or relationship between the variables. It is important to write the null hypothesis because it allows you to compare your results with what would be expected by chance.
Refine the Hypothesis
After formulating the hypothesis, it’s important to refine it and make it more precise. This may involve clarifying the variables, specifying the direction of the relationship, or making the hypothesis more testable.
Examples of Hypothesis
Here are a few examples of hypotheses in different fields:
Psychology : “Increased exposure to violent video games leads to increased aggressive behavior in adolescents.”
Biology : “Higher levels of carbon dioxide in the atmosphere will lead to increased plant growth.”
Sociology : “Individuals who grow up in households with higher socioeconomic status will have higher levels of education and income as adults.”
Education : “Implementing a new teaching method will result in higher student achievement scores.”
Marketing : “Customers who receive a personalized email will be more likely to make a purchase than those who receive a generic email.”
Physics : “An increase in temperature will cause an increase in the volume of a gas, assuming all other variables remain constant.”
Medicine : “Consuming a diet high in saturated fats will increase the risk of developing heart disease.”
Purpose of Hypothesis
The purpose of a hypothesis is to provide a testable explanation for an observed phenomenon or a prediction of a future outcome based on existing knowledge or theories. A hypothesis is an essential part of the scientific method and helps to guide the research process by providing a clear focus for investigation. It enables scientists to design experiments or studies to gather evidence and data that can support or refute the proposed explanation or prediction.
The formulation of a hypothesis is based on existing knowledge, observations, and theories, and it should be specific, testable, and falsifiable. A specific hypothesis helps to define the research question, which is important in the research process as it guides the selection of an appropriate research design and methodology. Testability of the hypothesis means that it can be proven or disproven through empirical data collection and analysis. Falsifiability means that the hypothesis should be formulated in such a way that it can be proven wrong if it is incorrect.
In addition to guiding the research process, the testing of hypotheses can lead to new discoveries and advancements in scientific knowledge. When a hypothesis is supported by the data, it can be used to develop new theories or models to explain the observed phenomenon. When a hypothesis is not supported by the data, it can help to refine existing theories or prompt the development of new hypotheses to explain the phenomenon.
When to use Hypothesis
Here are some common situations in which hypotheses are used:
In scientific research , hypotheses are used to guide the design of experiments and to help researchers make predictions about the outcomes of those experiments.
In social science research , hypotheses are used to test theories about human behavior, social relationships, and other phenomena.
I n business , hypotheses can be used to guide decisions about marketing, product development, and other areas. For example, a hypothesis might be that a new product will sell well in a particular market, and this hypothesis can be tested through market research.
Characteristics of Hypothesis
Here are some common characteristics of a hypothesis:
Testable : A hypothesis must be able to be tested through observation or experimentation. This means that it must be possible to collect data that will either support or refute the hypothesis.
Falsifiable : A hypothesis must be able to be proven false if it is not supported by the data. If a hypothesis cannot be falsified, then it is not a scientific hypothesis.
Clear and concise : A hypothesis should be stated in a clear and concise manner so that it can be easily understood and tested.
Based on existing knowledge : A hypothesis should be based on existing knowledge and research in the field. It should not be based on personal beliefs or opinions.
Specific : A hypothesis should be specific in terms of the variables being tested and the predicted outcome. This will help to ensure that the research is focused and well-designed.
Tentative: A hypothesis is a tentative statement or assumption that requires further testing and evidence to be confirmed or refuted. It is not a final conclusion or assertion.
Relevant : A hypothesis should be relevant to the research question or problem being studied. It should address a gap in knowledge or provide a new perspective on the issue.
Advantages of Hypothesis
Hypotheses have several advantages in scientific research and experimentation:
Guides research: A hypothesis provides a clear and specific direction for research. It helps to focus the research question, select appropriate methods and variables, and interpret the results.
Predictive powe r: A hypothesis makes predictions about the outcome of research, which can be tested through experimentation. This allows researchers to evaluate the validity of the hypothesis and make new discoveries.
Facilitates communication: A hypothesis provides a common language and framework for scientists to communicate with one another about their research. This helps to facilitate the exchange of ideas and promotes collaboration.
Efficient use of resources: A hypothesis helps researchers to use their time, resources, and funding efficiently by directing them towards specific research questions and methods that are most likely to yield results.
Provides a basis for further research: A hypothesis that is supported by data provides a basis for further research and exploration. It can lead to new hypotheses, theories, and discoveries.
Increases objectivity: A hypothesis can help to increase objectivity in research by providing a clear and specific framework for testing and interpreting results. This can reduce bias and increase the reliability of research findings.
Limitations of Hypothesis
Some Limitations of the Hypothesis are as follows:
Limited to observable phenomena: Hypotheses are limited to observable phenomena and cannot account for unobservable or intangible factors. This means that some research questions may not be amenable to hypothesis testing.
May be inaccurate or incomplete: Hypotheses are based on existing knowledge and research, which may be incomplete or inaccurate. This can lead to flawed hypotheses and erroneous conclusions.
May be biased: Hypotheses may be biased by the researcher’s own beliefs, values, or assumptions. This can lead to selective interpretation of data and a lack of objectivity in research.
Cannot prove causation: A hypothesis can only show a correlation between variables, but it cannot prove causation. This requires further experimentation and analysis.
Limited to specific contexts: Hypotheses are limited to specific contexts and may not be generalizable to other situations or populations. This means that results may not be applicable in other contexts or may require further testing.
May be affected by chance : Hypotheses may be affected by chance or random variation, which can obscure or distort the true relationship between variables.
About the author
Muhammad Hassan
Researcher, Academic Writer, Web developer
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Fundamentals of Hypothesis Testing: One-Sample Tests
hypothesis meaning test
hypothesis testing examples
Hypothesis Testing
VIDEO
Introduction to Hypothesis Testing
Research Hypothesis शोध परिकल्पना
Testing of hypothesis| Null and alternate Hypothesis
Hypothesis Meaning in Bengali
Hypothesis Testing කල්පිත පරීක්ෂාව
Stats Micro Lessons 27: Hypothesis Testing in Statistics
COMMENTS
Hypothesis Testing
Present the findings in your results and discussion section. Though the specific details might vary, the procedure you will use when testing a hypothesis will always follow some version of these steps. Table of contents. Step 1: State your null and alternate hypothesis. Step 2: Collect data. Step 3: Perform a statistical test.
Mean Population IQ: 100. Step 1: Using the value of the mean population IQ, we establish the null hypothesis as 100. Step 2: State that the alternative hypothesis is greater than 100. Step 3: State the alpha level as 0.05 or 5%. Step 4: Find the rejection region area (given by your alpha level above) from the z-table.
What is Hypothesis Testing?
Hypothesis testing is a statistical approach used in making decisions about data. In hypothesis testing, there are two hypotheses that are posed by the researcher and they are…. Null hypothesis-There is no difference between the sample population and the statistical population in relation to the mean or some other parameter that is being ...
Hypothesis Testing: Uses, Steps & Example
The researchers write their hypotheses. These statements apply to the population, so they use the mu (μ) symbol for the population mean parameter.. Null Hypothesis (H 0): The population means of the test scores for the two groups are equal (μ 1 = μ 2).; Alternative Hypothesis (H A): The population means of the test scores for the two groups are unequal (μ 1 ≠ μ 2).
Introduction to Hypothesis Testing
A statistical hypothesis is an assumption about a population parameter.. For example, we may assume that the mean height of a male in the U.S. is 70 inches. The assumption about the height is the statistical hypothesis and the true mean height of a male in the U.S. is the population parameter.. A hypothesis test is a formal statistical test we use to reject or fail to reject a statistical ...
Statistical hypothesis test
A statistical hypothesis test is a method of statistical inference used to decide whether the data sufficiently support a particular hypothesis. A statistical hypothesis test typically involves a calculation of a test statistic. Then a decision is made, either by comparing the test statistic to a critical value or equivalently by evaluating a p ...
Hypothesis Testing Definition, Steps & Examples
Hypothesis Testing Steps. There are 5 main hypothesis testing steps, which will be outlined in this section. The steps are: Determine the null hypothesis: In this step, the statistician should ...
Practical Teaching Strategies for Hypothesis Testing
The expected educational outcome is the conceptual understanding of the elements of statistical testing rather than learning about a specific testing methodology. Using the proposed practices, students are guided to propose their own hypotheses, collect actual data, and make their own inferences, rather than following a predetermined sequence ...
7.1: Basics of Hypothesis Testing
Test Statistic: z = ¯ x − μo σ / √n since it is calculated as part of the testing of the hypothesis. Definition 7.1.4. p - value: probability that the test statistic will take on more extreme values than the observed test statistic, given that the null hypothesis is true.
9.1: Introduction to Hypothesis Testing
In hypothesis testing, the goal is to see if there is sufficient statistical evidence to reject a presumed null hypothesis in favor of a conjectured alternative hypothesis.The null hypothesis is usually denoted \(H_0\) while the alternative hypothesis is usually denoted \(H_1\). An hypothesis test is a statistical decision; the conclusion will either be to reject the null hypothesis in favor ...
Hypothesis Testing
The first step in hypothesis testing is to set a research hypothesis. In Sarah and Mike's study, the aim is to examine the effect that two different teaching methods - providing both lectures and seminar classes (Sarah), and providing lectures by themselves (Mike) - had on the performance of Sarah's 50 students and Mike's 50 students.
PDF Introduction to Hypothesis Testing
8.2 FOUR STEPS TO HYPOTHESIS TESTING The goal of hypothesis testing is to determine the likelihood that a population parameter, such as the mean, is likely to be true. In this section, we describe the four steps of hypothesis testing that were briefly introduced in Section 8.1: Step 1: State the hypotheses. Step 2: Set the criteria for a decision.
Hypothesis Testing
A hypothesis test is a statistical inference method used to test the significance of a proposed (hypothesized) relation between population statistics (parameters) and their corresponding sample estimators. In other words, hypothesis tests are used to determine if there is enough evidence in a sample to prove a hypothesis true for the entire population. The test considers two hypotheses: the ...
An Introduction to Statistics: Understanding Hypothesis Testing and
HYPOTHESIS TESTING. A clinical trial begins with an assumption or belief, and then proceeds to either prove or disprove this assumption. In statistical terms, this belief or assumption is known as a hypothesis. Counterintuitively, what the researcher believes in (or is trying to prove) is called the "alternate" hypothesis, and the opposite ...
Significance tests (hypothesis testing)
Significance tests give us a formal process for using sample data to evaluate the likelihood of some claim about a population value. Learn how to conduct significance tests and calculate p-values to see how likely a sample result is to occur by random chance. You'll also see how we use p-values to make conclusions about hypotheses.
Hypothesis: Definition, Examples, and Types
A hypothesis is a tentative statement about the relationship between two or more variables. It is a specific, testable prediction about what you expect to happen in a study. It is a preliminary answer to your question that helps guide the research process. Consider a study designed to examine the relationship between sleep deprivation and test ...
Hypothesis tests
A hypothesis test is a procedure used in statistics to assess whether a particular viewpoint is likely to be true. They follow a strict protocol, and they generate a 'p-value', on the basis of which a decision is made about the truth of the hypothesis under investigation.All of the routine statistical 'tests' used in research—t-tests, χ 2 tests, Mann-Whitney tests, etc.—are all ...
Hypothesis Testing for Means & Proportions
We then determine the appropriate test statistic (Step 2) for the hypothesis test. The formula for the test statistic is given below. Test Statistic for Testing H0: p = p 0. if min (np 0 , n (1-p 0 )) > 5. The formula above is appropriate for large samples, defined when the smaller of np 0 and n (1-p 0) is at least 5.
How to Write a Strong Hypothesis
Developing a hypothesis (with example) Step 1. Ask a question. Writing a hypothesis begins with a research question that you want to answer. The question should be focused, specific, and researchable within the constraints of your project. Example: Research question.
Hypothesis Testing: 4 Steps and Example
Hypothesis testing is an act in statistics whereby an analyst tests an assumption regarding a population parameter. The methodology employed by the analyst depends on the nature of the data used ...
What Is A Research Hypothesis? A Simple Definition
A research hypothesis (also called a scientific hypothesis) is a statement about the expected outcome of a study (for example, a dissertation or thesis). To constitute a quality hypothesis, the statement needs to have three attributes - specificity, clarity and testability. Let's take a look at these more closely.
What is a Hypothesis
Definition: Hypothesis is an educated guess or proposed explanation for a phenomenon, based on some initial observations or data. It is a tentative statement that can be tested and potentially proven or disproven through further investigation and experimentation. Hypothesis is often used in scientific research to guide the design of experiments ...
Hypothesis for Education : Hypothesis
Educators supporting educators in social learning. Hypothesis is committed to helping institutions implement and realize the full potential of social annotation. Our team includes former educators that inform our product roadmap and develop various complimentary resources.
IMAGES
VIDEO
COMMENTS
Present the findings in your results and discussion section. Though the specific details might vary, the procedure you will use when testing a hypothesis will always follow some version of these steps. Table of contents. Step 1: State your null and alternate hypothesis. Step 2: Collect data. Step 3: Perform a statistical test.
Mean Population IQ: 100. Step 1: Using the value of the mean population IQ, we establish the null hypothesis as 100. Step 2: State that the alternative hypothesis is greater than 100. Step 3: State the alpha level as 0.05 or 5%. Step 4: Find the rejection region area (given by your alpha level above) from the z-table.
Hypothesis testing is a statistical approach used in making decisions about data. In hypothesis testing, there are two hypotheses that are posed by the researcher and they are…. Null hypothesis-There is no difference between the sample population and the statistical population in relation to the mean or some other parameter that is being ...
The researchers write their hypotheses. These statements apply to the population, so they use the mu (μ) symbol for the population mean parameter.. Null Hypothesis (H 0): The population means of the test scores for the two groups are equal (μ 1 = μ 2).; Alternative Hypothesis (H A): The population means of the test scores for the two groups are unequal (μ 1 ≠ μ 2).
A statistical hypothesis is an assumption about a population parameter.. For example, we may assume that the mean height of a male in the U.S. is 70 inches. The assumption about the height is the statistical hypothesis and the true mean height of a male in the U.S. is the population parameter.. A hypothesis test is a formal statistical test we use to reject or fail to reject a statistical ...
A statistical hypothesis test is a method of statistical inference used to decide whether the data sufficiently support a particular hypothesis. A statistical hypothesis test typically involves a calculation of a test statistic. Then a decision is made, either by comparing the test statistic to a critical value or equivalently by evaluating a p ...
Hypothesis Testing Steps. There are 5 main hypothesis testing steps, which will be outlined in this section. The steps are: Determine the null hypothesis: In this step, the statistician should ...
The expected educational outcome is the conceptual understanding of the elements of statistical testing rather than learning about a specific testing methodology. Using the proposed practices, students are guided to propose their own hypotheses, collect actual data, and make their own inferences, rather than following a predetermined sequence ...
Test Statistic: z = ¯ x − μo σ / √n since it is calculated as part of the testing of the hypothesis. Definition 7.1.4. p - value: probability that the test statistic will take on more extreme values than the observed test statistic, given that the null hypothesis is true.
In hypothesis testing, the goal is to see if there is sufficient statistical evidence to reject a presumed null hypothesis in favor of a conjectured alternative hypothesis.The null hypothesis is usually denoted \(H_0\) while the alternative hypothesis is usually denoted \(H_1\). An hypothesis test is a statistical decision; the conclusion will either be to reject the null hypothesis in favor ...
The first step in hypothesis testing is to set a research hypothesis. In Sarah and Mike's study, the aim is to examine the effect that two different teaching methods - providing both lectures and seminar classes (Sarah), and providing lectures by themselves (Mike) - had on the performance of Sarah's 50 students and Mike's 50 students.
8.2 FOUR STEPS TO HYPOTHESIS TESTING The goal of hypothesis testing is to determine the likelihood that a population parameter, such as the mean, is likely to be true. In this section, we describe the four steps of hypothesis testing that were briefly introduced in Section 8.1: Step 1: State the hypotheses. Step 2: Set the criteria for a decision.
A hypothesis test is a statistical inference method used to test the significance of a proposed (hypothesized) relation between population statistics (parameters) and their corresponding sample estimators. In other words, hypothesis tests are used to determine if there is enough evidence in a sample to prove a hypothesis true for the entire population. The test considers two hypotheses: the ...
HYPOTHESIS TESTING. A clinical trial begins with an assumption or belief, and then proceeds to either prove or disprove this assumption. In statistical terms, this belief or assumption is known as a hypothesis. Counterintuitively, what the researcher believes in (or is trying to prove) is called the "alternate" hypothesis, and the opposite ...
Significance tests give us a formal process for using sample data to evaluate the likelihood of some claim about a population value. Learn how to conduct significance tests and calculate p-values to see how likely a sample result is to occur by random chance. You'll also see how we use p-values to make conclusions about hypotheses.
A hypothesis is a tentative statement about the relationship between two or more variables. It is a specific, testable prediction about what you expect to happen in a study. It is a preliminary answer to your question that helps guide the research process. Consider a study designed to examine the relationship between sleep deprivation and test ...
A hypothesis test is a procedure used in statistics to assess whether a particular viewpoint is likely to be true. They follow a strict protocol, and they generate a 'p-value', on the basis of which a decision is made about the truth of the hypothesis under investigation.All of the routine statistical 'tests' used in research—t-tests, χ 2 tests, Mann-Whitney tests, etc.—are all ...
We then determine the appropriate test statistic (Step 2) for the hypothesis test. The formula for the test statistic is given below. Test Statistic for Testing H0: p = p 0. if min (np 0 , n (1-p 0 )) > 5. The formula above is appropriate for large samples, defined when the smaller of np 0 and n (1-p 0) is at least 5.
Developing a hypothesis (with example) Step 1. Ask a question. Writing a hypothesis begins with a research question that you want to answer. The question should be focused, specific, and researchable within the constraints of your project. Example: Research question.
Hypothesis testing is an act in statistics whereby an analyst tests an assumption regarding a population parameter. The methodology employed by the analyst depends on the nature of the data used ...
A research hypothesis (also called a scientific hypothesis) is a statement about the expected outcome of a study (for example, a dissertation or thesis). To constitute a quality hypothesis, the statement needs to have three attributes - specificity, clarity and testability. Let's take a look at these more closely.
Definition: Hypothesis is an educated guess or proposed explanation for a phenomenon, based on some initial observations or data. It is a tentative statement that can be tested and potentially proven or disproven through further investigation and experimentation. Hypothesis is often used in scientific research to guide the design of experiments ...
Educators supporting educators in social learning. Hypothesis is committed to helping institutions implement and realize the full potential of social annotation. Our team includes former educators that inform our product roadmap and develop various complimentary resources.